A5051954068- Pain Management and Opioid Use
- Cardiac pacing and defibrillation studies
- Pain Management and Treatment
- Cardiovascular Syncope and Autonomic Disorders
- Spine and Intervertebral Disc Pathology
- Pain Mechanisms and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Anesthesia and Pain Management
- Neuropeptides and Animal Physiology
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Histone Deacetylase Inhibitors Research
- Pharmacological Effects and Toxicity Studies
- Amyotrophic Lateral Sclerosis Research
- Musculoskeletal pain and rehabilitation
- Cancer Treatment and Pharmacology
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Neurological diseases and metabolism
- Cerebral Venous Sinus Thrombosis
- Heart Rate Variability and Autonomic Control
- French Urban and Social Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Ion channel regulation and function
Duke University
2017-2021
Clinical Research Institute
2018
Duke University Hospital
2016
Duke Medical Center
2016
University of North Carolina at Chapel Hill
2012-2015
Northwestern University
2012
Williams & Associates
2012
University of North Carolina Hospitals
2012
Gundersen Health System
2006
Virginia Commonwealth University
2005
Implantable intrathecal drug delivery systems (IDDSs) have been used to manage refractory cancer pain, but there are no randomized clinical trial (RCT) data comparing them with comprehensive medical management (CMM).We enrolled 202 patients on an RCT of CMM versus IDDS plus CMM. Entry criteria included unrelieved pain (visual analog scale [VAS] scores >/= 5 a 0 10 scale). Clinical success was defined as 20% reduction in VAS scores, or equal toxicity. The main outcome measure control combined...
Background Preclinical studies suggest that opioids may promote tumor growth. Genetic polymorphisms have been shown to affect opioid receptor function and modify the clinical effects of morphine. In this study we assessed association between six common in μ-opioid gene, including well known A118G polymorphism, breast cancer survival. Methods A total 2,039 women ages 23-74 yr (38% African-American, 62% European-American, 55% postmenopausal) diagnosed with 1993-2001 were followed through 2006....
Ventricular tachycardia (VT), ventricular fibrillation (VF), and electrical storm are commonly encountered emergency conditions in cardiac surgical intensive care units. In most cases, recurrent arrhythmias or associated with a heightened sympathetic tone. These can be difficult to treat may refractory beta-blockade, antiarrhythmic therapy, sedation, mechanical hemodynamic support. While monomorphic PVC-triggered polymorphic sometimes amenable successful ablation, some patients too...
Abstract Traditional classification and prognostic approaches for chronic pain conditions focus primarily on anatomically based clinical characteristics not underlying biopsychosocial factors contributing to perception of future trajectories. Using a supervised clustering approach in cohort temporomandibular disorder cases controls from the Orofacial Pain: Prospective Evaluation Risk Assessment study, we recently developed validated rapid algorithm (ROPA) pragmatically classify patients into...
This study examined the effects of 365 occurrences on intracranial pressure (ICP) four patients with severe head injuries and a Glasgow Coma Score below five. The were in: 1) health care activities, 2) patient-initiated 3) environmental stimuli. activities that increased suctioning, turning, flexion head; decreases realized by elevating bed repositioning patient. extremities, rotation neck, coughing. In contrast to previous reports, stimuli did not affect bathing it. Recommendations for...
Background There is limited neuropathologic information available from cases of Sneddon’s syndrome in which strokes are associated with livedo reticularis. Pathogenesis the controversial, although current opinion favors a coagulopathy, often antiphospholipid antibodies. We describe case lacking antibodies but having granulomatous infiltration leptomeninges. Case Description The patient presented at age 29 stroke, reticularis, essential hypertension, and Raynaud’s phenomenon. Assessment...
Bortsov, Andrey V.; Millikan, Robert C.; Belfer, Inna; Boortz-Marx, Richard L.; Arora, Harendra; McLean, Samuel A. Author Information