A5036200659- Growth Hormone and Insulin-like Growth Factors
- Sexual Differentiation and Disorders
- Childhood Cancer Survivors' Quality of Life
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cardiac pacing and defibrillation studies
- Acute Lymphoblastic Leukemia research
- Thyroid Disorders and Treatments
- Adrenal Hormones and Disorders
- Cardiac electrophysiology and arrhythmias
- Pituitary Gland Disorders and Treatments
- Birth, Development, and Health
- Hormonal and reproductive studies
- Congenital Diaphragmatic Hernia Studies
- Congenital Anomalies and Fetal Surgery
- Cancer Risks and Factors
- Renal and related cancers
- Hypothalamic control of reproductive hormones
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Testicular diseases and treatments
- Head and Neck Surgical Oncology
- Cardiovascular Function and Risk Factors
- Metabolism, Diabetes, and Cancer
Universidade Federal de São Paulo
2015-2025
Support group for adolescents and children with cancer
2015-2025
Ospedale Sandro Pertini
2010-2023
Aziende Socio Sanitaria Territoriale Rhodense
2023
Ospedale Santa Maria
2023
Presidio Ospedaliero
2023
University of L'Aquila
2023
Pontificia Universidad Javeriana
2019
Washington University in St. Louis
2013-2016
Union des Industries Ferroviaires Européennes
2015
Fibroblast growth factor (FGF) signaling is cardioprotective in various models of myocardial infarction. FGF receptors (FGFRs) are expressed multiple cell types the adult heart, but type-specific FGFR that mediates different endpoints not known. To determine requirement for endothelium cardiac ischemia-reperfusion injury, we conditionally inactivated Fgfr1 and Fgfr2 genes endothelial cells with Tie2-Cre (Tie2-Cre, Fgfr1(f/f), Fgfr2(f/f) DCKO mice). Tie2-Cre, mice had normal baseline...
Fibroblast growth factors (FGFs) and their receptors are highly conserved signaling molecules that have been implicated in postnatal cardiac remodeling. However, it is not known whether cardiomyocyte-expressed FGF necessary or sufficient for ventricular remodeling the adult heart. To determine cardiomyocytes were competent to respond an activated receptor, if this signal would result development of hypertrophy, we engineered a doxycycline (DOX)-inducible, cardiomyocyte-specific,...
Pleuropulmonary Blastoma (PPB) is the primary neoplastic manifestation of a pediatric cancer predisposition syndrome that associated with several diseases including cystic nephroma, Wilms tumor, neuroblastoma, rhabdomyosarcoma, medulloblastoma, and ovarian Sertoli-Leydig cell tumor. The pathology PPB, epithelial cysts stromal hyperplasia risk for progression to complex primitive sarcoma, familial heterozygosity lesion-associated loss-of-heterozygosity DICER1. It has been hypothesized loss...
Fibroblast growth factor 2 (FGF2) is cardioprotective in vivo models of myocardial infarction; however, whether FGF2 has a protective role ischemia-reperfusion (IR) injury, model that more closely mimics acute infarction humans, not known. To assess the efficacy endogenous FGF2, mice lacking functional Fgf2 gene (Fgf2−/−) and wild-type controls were subjected to closed-chest regional cardiac IR injury (90 min ischemia, 7 days reperfusion). Fgf2−/− had significantly increased infarct size...
An implantable loop recorder (ILR) is indicated in patients with unexplained syncope after complete conventional work-up. Data from the literature imply that, clinical practice, ILR underused. The aim of study was to verify if there any discrepancy between use ILRs practice and potential indications based on most potentially appropriate guideline indications. We compared prevalence actually implanted Syncope Unit Project (SUP) one using standard given by guidelines. In SUP study, 28 (18%)...
Abstract Craniopharyngioma is a sellar/suprasellar benign tumor whose aggressiveness may imply in endocrine disturbances (hypothalamic obesity and hormone deficiencies). Fifty-seven patients were evaluated according to clinical characteristics, hypothalamic involvement, type of treatment, anthropometric variables, adiposity indexes (body mass index Z score category at diagnosis post-treatment, total body fat, visceral adipose tissue, metabolic syndrome components) analyzed through multiple...
Abstract Background Advances in treatment of acute lymphocytic leukemia increased the likelihood developing late treatment-associated effects, such as abdominal adiposity, increasing risk cardiovascular disease this population. Cranial radiotherapy is one factors that might be involved process. The aim study was to determine effect cranial on adiposity indexes survivors leukemia. Methods A comparative cross-sectional 56 survivors, chronological age between 15 and 24 years, assigned into two...
Patients at risk of sudden cardiac death (SCD) after myocardial infarction (MI) can be offered therapy with implantable cardioverter defibrillators (ICDs). Whether plasma biomarkers help stratify for SCD and ventricular arrhythmias (VT/VF) is unclear. The primary objective the CAMI-GUIDE study to assess predictive role C-reactive protein or VT/VF in ischaemic patients ejection fraction <30% ICDs. Secondary endpoints included all-cause mortality, hospitalizations, from heart failure....
Several Armour thyrotrophin preparations were labeled with different amounts of a fluorescent dye, acid rhodamine B (Lissamine-Rhodamine 200, Imperial Chemical Industries, Ltd.) following Chadwick's method slight modifications. The native lost from 12 to 34% its biological activity after labeling, proved by Gilliland's method. A portion the same was denaturated heating in acetic medium. Different lots rats intravenously injected thyrotrophin, and dye solution respectively. It observed: 1)...
FISH has been used as a complement to classical cytogenetics in the detection of mosaicism sex chromosome anomalies. The aim this study is describe three cases which final diagnosis could only be achieved by FISH. Case 1 was an 8-year-old 46,XY girl with normal female genitalia referred our service because short stature. analysis lymphocytes probes for X and Y centromeres identified 45,X/46,X,idic(Y) constitution, established Turner syndrome. 2 21-month-old boy genital ambiguity (penile...
Androgens are responsible for the development and maintenance of male sex characteristics. Dysfunctions in androgen action due to mutations receptor gene (<i>AR</i>) can lead insensitivity syndrome (AIS) that be classified as mild (MAIS), partial (PAIS), or complete (CAIS). We have analyzed functional effects p.Ser760Thr, p.Leu831Phe, p.Ile899Phe, p.Leu769Val, p.Pro905Arg combination p.Gln799Glu + p.Cys807Phe were identified patients with PAIS CAIS. The p.Leu769Val showed...
Leptin has been hypothesized to play a role in the development of obesity leukemia survivors, particularly those who have received cranial radiotherapy. This cross-sectional study evaluated relationship between leptin levels and body mass index (BMI) sample 26 acute lymphocytic survivors both sexes, treated with without irradiation, aged 7.6 17 years, at mean 3.4+/-2.0 years off treatment. There were significantly more males among irradiated group (P<0.001), even though no differences...
The basal encephaloceles refer to rare entities and they correspond herniation of brain tissue through defects skull along the cribiform plate or sphenoid bone. A morning glory syndrome, with characteristic retinal defect has been reported in association encephaloceles. Hypophysis hormonal deficiencies may occur. We accounted for a pituitary dwarfism delayed diagnosed transsphenoidal encephalocele associated showing alterations found retinography, computed tomography magnetic resonance imaging.
OBJECTIVE: To analyze traits of metabolic syndrome (MetS) in medulloblastoma survivors. SUBJECTS AND METHODS: Sixteen childhood survivors aged 18.0 (4.4) years, with history craniospinal radiation therapy (RT) were compared nine control subjects matched by age, gender, and body mass index, according to fat distribution, cardiovascular variables. RESULTS: Medulloblastoma patients showed increases waist circum-ference its relationships (all p < 0.05), HOMA1-IR (p = 0.006), which modified...