A5043192448- Childhood Cancer Survivors' Quality of Life
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Renal and related cancers
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Acute Lymphoblastic Leukemia research
- Genetic factors in colorectal cancer
- Renal cell carcinoma treatment
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Pediatric Urology and Nephrology Studies
- Genomics and Rare Diseases
- Cancer-related gene regulation
- Hematopoietic Stem Cell Transplantation
- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Histiocytic Disorders and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ethics and Legal Issues in Pediatric Healthcare
- Ferroptosis and cancer prognosis
- Tuberous Sclerosis Complex Research
- Lipid metabolism and biosynthesis
- Beetle Biology and Toxicology Studies
- Surgical site infection prevention
Support group for adolescents and children with cancer
2016-2025
Universidade Federal de São Paulo
2011-2024
Union des Industries Ferroviaires Européennes
2021
Instituto de Oncologia do Paraná
2015
// Mariana Maschietto 1, * , Tatiane Cristina Rodrigues 2, André Yoshiaki Kashiwabara 3 Érica Sara Souza de Araujo 4 Talita Ferreira Marques Aguiar Cecilia Maria Lima da Costa 5 Isabela Werneck Cunha 6 Luciana dos Reis Vasques 2 Monica Cypriano 7 Helena Brentani 8 Silvia Regina Caminada Toledo Peter Lees Pearson Dirce Carraro Carla Rosenberg Ana C.V. Krepischi 1 Brazilian Biosciences National Laboratory (LNBio), Center for Research in Energy and Materials (CNPEM), Campinas, Brazil Department...
Hepatoblastoma is an embryonal liver tumor carrying few genetic alterations. We previously disclosed in hepatoblastomas a genome-wide methylation dysfunction, characterized by hypermethylation at specific CpG islands, addition to low-level hypomethylation pattern non-repetitive intergenic sequences, comparison non-tumoral tissues, shedding light into crucial role for epigenetic dysregulation this type of cancer. To explore the underlying mechanisms possibly related aberrant modifications, we...
Hepatoblastomas exhibit the lowest mutational burden among pediatric tumors. We previously showed that epigenetic disruption is crucial for hepatoblastoma carcinogenesis. Our data revealed hypermethylation of nicotinamide N-methyltransferase, a highly expressed gene in adipocytes and hepatocytes. The expression pattern role N-methyltransferase liver tumors have not yet been explored, this study aimed to evaluate effect hepatoblastomas. evaluated 45 hepatoblastomas 26 non-tumoral samples....
Vascular extension to the vena cava occurs in 4% of Wilms tumor cases and can reach right atrium up 1%. When this happens thrombus is usually not adherent vessel wall, there blood flow around it. Preoperative chemotherapy cause regression even resolution. If persists after chemotherapy, surgery will be a challenge. On other hand, if invades its removal may feasible. In situation cavectomy good surgical strategy because it provides complete resection. The prerequisite for absence on...
Hepatoblastoma is a very rare embryonal liver cancer supposed to arise from the impairment of hepatocyte differentiation during embryogenesis. In this study, we investigated by exome sequencing burden somatic mutations in cohort 10 hepatoblastomas, including congenital case. Our data disclosed low mutational background and pointed out novel set candidate genes for hepatoblastoma biology, which were shown impact gene expression levels. Only three recurrently mutated detected: CTNNB1 two...
Background: Pediatric tumors can present with vascular extension to the inferior vena cava and right atrium, which impacts surgical strategy be challenging during treatment. Wilms tumor (WT) is most common retroperitoneal that extension, but also adrenal tumors, clear cell from kidney, hepatoblastomas this situation. Surgical aims include obtaining complete resection without risk for patients, avoid severe bleeding, cardiac arrest, embolization, bypass if possible. Objective: To describe...
Aim: This study aimed to analyze clinical characteristics and image findings in patients initially diagnosed with renal masses treated on the Société Internationale d'Oncologie Pédiatrique (SIOP) 2001 protocol for Wilms tumor (WT) that eventually were different pathologies. Methods: We reviewed preoperative symptoms, laboratory tests, images of who WT proved have other diagnoses. Data from these compared those last 10 neuroblastoma (NBL) at a single institution. Results: From June December...
Purpose: Little information is available regarding the tumor features, prognostic factors, and treatment results in children adolescents young adults (AYAs) with osteosarcoma diagnosed developing countries. We reviewed of three observational cohorts patients treated an emerging country. Methods: A total 604 below age 30 years high-grade were prospectively enrolled Brazilian Osteosarcoma Treatment Group (BOTG) studies III, IV, V. Gender, age, time from onset symptoms to diagnosis, primary...
The ultrarare hepatoblastoma (HB) is the most common pediatric liver cancer. HB risk related to a few rare syndromes, and molecular bases remain elusive for cases. We investigated burden of damaging germline variants in 30 Brazilian patients with presence additional clinical signs. A high frequency prematurity (20%) birth defects (37%), especially craniofacial (17%, including craniosynostosis) kidney (7%) anomalies, was observed. Putative pathogenic or likely monoallelic mapped 10 cancer...
PURPOSE: Conservative management has been largely used for renal trauma. Although this approach is safe and highly recommended, it can hide a pre-existing unknown condition, such as tumors or urinary malformations. A high index of suspicion needed early recognition these conditions. We present four cases treated at the Pediatric Oncology Institute - Federal University São Paulo, which have initially conservatively MATERIALS AND METHODS: reviewed all 218 our institution in 22-year period,...
O câncer representa hoje a primeira causa de morte por doença entre população faixa etária compreendida 1 e 21 anos nos Estados Unidos em outros países economicamente desenvolvidos. No Brasil, esta figura como terceira 14 anos, sendo já óbito no município estado São Paulo grupo etário compreendido 5 excluindo-se acidentes causas externas. objetivo deste artigo é informar classe médica, principalmente pediátrica, das particularidades do infantil suas diferenças com as formas dos adultos, mais...
Obesity is a late effect in survivors of childhood cancer and correlates with chronic complications. Survivors leukemia, brain tumors, hematopoietic stem cell transplantation are more likely to develop obesity resulting from treatment modalities such as radiotherapy glucocorticoids. This paper analyzes integrates the current data available health professionals order clarify strategies that can be used treat prevent survivors. literature review on scientifically reliable electronic databases....
Hemophagocytic lymphohistiocytosis comprises a systemic hyperactivation of macrophages that requires prompt recognition symptoms and early treatment.In this context, we described clinical laboratory characteristics, therapeutic modality outcome 21 patients with HLH treated at pediatric oncology hospital between January 2000 February 2019.HLH mainly affected females, fever was the most frequent sign hyperferritinemia prevalent abnormality. All were admitted to intensive care unit (ICU) some...