A5003501488- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Genomics and Rare Diseases
- Cancer-related gene regulation
- Science and Education Research
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic and Kidney Cyst Diseases
- Ferroptosis and cancer prognosis
- T-cell and B-cell Immunology
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- Ion channel regulation and function
- Phytochemistry Medicinal Plant Applications
- Birth, Development, and Health
- Neurofibromatosis and Schwannoma Cases
- Tea Polyphenols and Effects
- Nitrogen and Sulfur Effects on Brassica
- Metabolomics and Mass Spectrometry Studies
- Ion Channels and Receptors
- Lipid metabolism and biosynthesis
Columbia University Irving Medical Center
2022-2024
Universidade de São Paulo
2018-2024
New York University
2021-2024
AC Camargo Hospital
2014-2020
Brvant (Brazil)
2020
Hemorio
2020
Stanford University
2018
While immunotherapy tends to be ineffective against pancreatic ductal adenocarcinoma (PDAC), this cancer type often elicits B-cell immunity. However, the exact antigens responsible for these spontaneous immune responses are still unclear. This study used a unique high-dimensional ELISA analyze IgG 93 post-translational modifications and other chemical determinants in PDAC patients at time of diagnosis before therapy. Results identified 13 specific targets serum that distinguished from...
// Mariana Maschietto 1, * , Tatiane Cristina Rodrigues 2, André Yoshiaki Kashiwabara 3 Érica Sara Souza de Araujo 4 Talita Ferreira Marques Aguiar Cecilia Maria Lima da Costa 5 Isabela Werneck Cunha 6 Luciana dos Reis Vasques 2 Monica Cypriano 7 Helena Brentani 8 Silvia Regina Caminada Toledo Peter Lees Pearson Dirce Carraro Carla Rosenberg Ana C.V. Krepischi 1 Brazilian Biosciences National Laboratory (LNBio), Center for Research in Energy and Materials (CNPEM), Campinas, Brazil Department...
Hepatoblastoma is an embryonal liver tumor carrying few genetic alterations. We previously disclosed in hepatoblastomas a genome-wide methylation dysfunction, characterized by hypermethylation at specific CpG islands, addition to low-level hypomethylation pattern non-repetitive intergenic sequences, comparison non-tumoral tissues, shedding light into crucial role for epigenetic dysregulation this type of cancer. To explore the underlying mechanisms possibly related aberrant modifications, we...
Hepatoblastomas exhibit the lowest mutational burden among pediatric tumors. We previously showed that epigenetic disruption is crucial for hepatoblastoma carcinogenesis. Our data revealed hypermethylation of nicotinamide N-methyltransferase, a highly expressed gene in adipocytes and hepatocytes. The expression pattern role N-methyltransferase liver tumors have not yet been explored, this study aimed to evaluate effect hepatoblastomas. evaluated 45 hepatoblastomas 26 non-tumoral samples....
Hepatoblastoma is a very rare embryonal liver cancer supposed to arise from the impairment of hepatocyte differentiation during embryogenesis. In this study, we investigated by exome sequencing burden somatic mutations in cohort 10 hepatoblastomas, including congenital case. Our data disclosed low mutational background and pointed out novel set candidate genes for hepatoblastoma biology, which were shown impact gene expression levels. Only three recurrently mutated detected: CTNNB1 two...
Hancornia speciosa GOMES is a Cerrado species widely used in food production, and because it presents several active compounds, the identification of potential candidates treatment diseases one most approaches drug research development. The aim study was to perform virtual screening compounds from H. evaluate silico antitumor breast cancer. In this focus investigate biocompounds found leaves, therefore databases Sciencedirect Pubmed were consulted, using descriptors "Hancornia speciosa" AND...
Abstract Mibefradil is a tetralol derivative originally developed as an antagonist of T-type voltage-gated calcium (Ca 2+ ) channels to treat hypertension when used at nanomolar dosage. More recently, its therapeutic application in has declined and been instead repurposed treatment cancer cell proliferation solid tumor growth. Beyond function Ca v blocker, the micromolar concentration mibefradil can stimulate rise [Ca ] cyt although mechanism poorly known. The chanzyme TRPM7 (transient...
The ultrarare hepatoblastoma (HB) is the most common pediatric liver cancer. HB risk related to a few rare syndromes, and molecular bases remain elusive for cases. We investigated burden of damaging germline variants in 30 Brazilian patients with presence additional clinical signs. A high frequency prematurity (20%) birth defects (37%), especially craniofacial (17%, including craniosynostosis) kidney (7%) anomalies, was observed. Putative pathogenic or likely monoallelic mapped 10 cancer...
Natural antibodies are an integral part of innate humoral immunity yet their development and polyreactive nature still enigmatic. Here, we show that characteristic monoclonal natural recognize common chemical moieties or adducts, supporting the view may often correspond to anti-adduct antibodies. We next examined immunoglobulin M (IgM) IgG 81 ubiquitous adducts from birth old age. Newborn IgM only reacted a limited number consensus determinants. This highly restricted neonatal repertoire...
Primary liver cancers are rare in children, and the most common type is hepatoblastoma (HB), an embryonal tumor with histological features that resemble different stages of cell differentiation. However, mainly because its rarity, molecular data on HB tumorigenesis remain scarce. This article reviews current knowledge regarding genetic epigenetic alterations reported cases, emphasis recent findings next-generation sequencing studies.
Cancer is one of the leading causes death in children and adolescents worldwide; among types liver cancer, hepatoblastoma (HBL) most common childhood. Although it affects only two to three individuals a million, mostly asymptomatic at diagnosis, so by time detected has already advanced. There are specific recommendations regarding HBL treatment, ongoing studies stratify risks HBL, understand pathology, predict prognostics survival rates. magnetic resonance imaging spectroscopy frequently...
Abstract Mosaic segmental and whole chromosome copy number alterations are postzygotic variations known to be associated with several disorders. We have previously presented an efficient targeted sequencing approach simultaneously detect point mutations (CNVs). In this study, we evaluated the efficiency of mosaic CNVs, using seven postnatal 19 tumor samples, characterized by chromosomal microarray analyses (CMA). These samples harbored a total 28 genomic imbalances ranging in size from 0.68...
Introduction Thymus resident B cells were described more than 40 years ago. In early human life, these are found predominantly in the medulla and overwhelmingly display an unswitched IgM+ phenotype. The reactivity of thymic IgM cells, however, is still unclear. Methods Here, we generated 120 IgM-producing cell clones from 3 separate thymus specimens obtained infant, adolescent, adult donors. Using flow cytometry a unique high-dimensional ELISA platform, investigated clones’ to apoptotic as...
ABSTRACT Background Hepatoblastoma is an embryonal liver tumor supposed to arise from the impairment of hepatocyte differentiation during embryogenesis. CTNNB1 only recurrently mutated gene, and this relative paucity somatic mutations poses a challenge risk stratification development targeted therapies. Methods In study, we investigated by exome sequencing burden in cohort 10 hepatoblastomas, including congenital case. Results Our data disclosed low mutational background with three genes:...
Abstract The incidence of pancreatic cancer has increased over the past several decades and is now fourth leading cause death in USA. Only 8.5% patients live beyond 5 years after their initial diagnosis. This dismal survival rate partly explained by fact that most cases are detected late when treatment options limited. Novel biomarkers crucially needed. It long been recognized cells abnormally accumulate chemical groups covalently linked to proteins, DNA other molecules. Humoral responses...
Com o intuito de celebrar a 19ª Semana Nacional Ciência e Tecnologia (SNCT), foram promovidas ações, em diferentes espaços, voltadas para comunidade geral, bem como estudantes da educação básica do ensino superior. As ações ocorreram ambiente virtual (circuito mesas redondas); formal (escola básica) ambientes não formais (galeria arte praça pública). Por meio exposições interativas, palestras atividades práticas, este projeto rompeu barreiras entre ciência sociedade, uma vez que houve...