A5028582007- Bone and Dental Protein Studies
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Connexins and lens biology
- RNA modifications and cancer
- Parathyroid Disorders and Treatments
- Neurobiology and Insect Physiology Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- dental development and anomalies
- Biochemical Acid Research Studies
- Receptor Mechanisms and Signaling
- ATP Synthase and ATPases Research
- Selenium in Biological Systems
- Fluoride Effects and Removal
- Ion Channels and Receptors
- Renin-Angiotensin System Studies
- Free Radicals and Antioxidants
- Cancer, Lipids, and Metabolism
- Muscle Physiology and Disorders
- Genetics, Aging, and Longevity in Model Organisms
- Cerebrovascular and genetic disorders
- Mercury impact and mitigation studies
- Ion channel regulation and function
- Hormonal Regulation and Hypertension
- Aldose Reductase and Taurine
The Graduate Center, CUNY
2023-2024
City University of New York
2023-2024
Baruch College
2024
Lehman College
2023-2024
New York University
2019-2022
Inorganic polyphosphate (polyP) is a linear polymer composed of up to few hundred orthophosphates linked together by high-energy phosphoanhydride bonds, identical with those found in ATP. In mammalian mitochondria, polyP has been implicated multiple processes, including energy metabolism, ion channels function, and the regulation calcium signaling. However, specific mechanisms all these effects within organelle remain poorly understood. The central goal this study was investigate how...
Abstract Mibefradil is a tetralol derivative originally developed as an antagonist of T-type voltage-gated calcium (Ca 2+ ) channels to treat hypertension when used at nanomolar dosage. More recently, its therapeutic application in has declined and been instead repurposed treatment cancer cell proliferation solid tumor growth. Beyond function Ca v blocker, the micromolar concentration mibefradil can stimulate rise [Ca ] cyt although mechanism poorly known. The chanzyme TRPM7 (transient...
The role of mitochondria in enamel, the most mineralized tissue body, is poorly defined. Enamel formed by ameloblast cells two main sequential stages known as secretory and maturation. Defining physiological features each stage essential to understand mineralization. Here, we analyzed functional rat primary maturation-stage ameloblasts focusing on their Ca2+ signaling. Quantification stored trifluoromethoxy carbonylcyanide phenylhydrazone stimulation was comparable both stages. release...
Enamel is the most calcified tissue in vertebrates. formation and mineralization a two-step process that mediated by ameloblast cells during their secretory maturation stages. In these two stages, ameloblasts are characterized different morphology function, which fundamental for proper mineral growth extracellular space. Ultrastructural studies have shown mitochondria localize to subcellular regions both However, limited knowledge available on role/s of enamel formation. To address this...
Abstract Triple negative breast cancer (TNBC) is one of the most aggressive subtypes cancer, accounting for 10-15% all cancers in women. The frequency metastasis TNBC disproportionally high compared to other and primary cause patient mortality. At cellular level, TNBC's nature demands rapid adaptation tumor cells navigate stressors survival metastatic transformation. These adaptations include a cell’s ability reprogram its metabolism regulate mRNA translation control, coordinating...
Abstract Translational control and metabolic reprogramming are hallmarks of advanced cancers. Important genes involved in cancer progression express mRNAs that selectively translated, including regulators cell metabolism. Cancer cells acquire an altered metabolism, switching from oxidative phosphorylation (OXPHOS) to a glycolytic phenotype (Warburg effect), increase reliance on alternate pathways support growth, proliferation, metastasis. Triple-negative breast (TNBC), one the most...
Calcium (Ca2+) extrusion is an essential function of the enamel-forming ameloblasts, providing Ca2+ for extracellular mineralization. The plasma membrane ATPases (PMCAs) remove cytosolic (cCa2+) and were recently shown to be efficient when ameloblasts experienced low cCa2+ elevation. Sodium–calcium (Na+/Ca2+) exchange has higher capacity extrude cCa2+, but there limited evidence on two main families Na+/Ca2+ exchangers in enamel formation. purpose this study was analyze NCX (coded by SLC8)...