A5013177039- Genetic factors in colorectal cancer
- Carcinogens and Genotoxicity Assessment
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Biochemical Analysis and Sensing Techniques
- Colorectal Cancer Screening and Detection
- BRCA gene mutations in cancer
- Dye analysis and toxicity
- Effects and risks of endocrine disrupting chemicals
- Antioxidant Activity and Oxidative Stress
- Environmental Toxicology and Ecotoxicology
- Pineapple and bromelain studies
- Phytochemistry Medicinal Plant Applications
- Retinoids in leukemia and cellular processes
- Nutrition and Health in Aging
- Healthcare Regulation
- Mycotoxins in Agriculture and Food
- Women's cancer prevention and management
- Estrogen and related hormone effects
- Health Education and Validation
- Essential Oils and Antimicrobial Activity
- Microbial Natural Products and Biosynthesis
- Nutrition, Genetics, and Disease
- Genomic variations and chromosomal abnormalities
- Chromatography in Natural Products
Universidade Federal do Piauí
2016-2025
Instituto Brasileiro de Controle do Câncer
2024
Georgia State University
2023
Universidade Federal de Alagoas
2022
AC Camargo Hospital
2009-2018
Ton Duc Thang University
2018
Centro Universitário UNINOVAFAPI
2017
Hospital São Paulo
2011-2013
Genomic (Brazil)
2013
Universidade de São Paulo
2012
The objective of this work was to investigate the antidiabetic, antiglycation, and antioxidant potentials ethanolic extract seeds Brazilian Passiflora edulis fruits (PESE), a major by-product juice industry, piceatannol (PIC), one main phytochemicals PESE. PESE, PIC, acarbose (ACB) exhibited IC50 for alpha-amylase, 32.1 ± 2.7, 85.4 0.7, 0.4 0.1 µg/mL, respectively, alpha-glucosidase, 76.2 1.9, 20.4 7.6, 252 4.5 respectively. sitagliptin (STG) dipeptidyl-peptidase-4 (DPP-4) 71.1 2.6, 1137...
Germ line mutations in BRCA1 and BRCA2 (BRCA1/2) other susceptibility genes have been identified as genetic causes of hereditary breast ovarian cancer (HBOC). To identify the disease-causing a cohort 120 Brazilian women fulfilling criteria for HBOC, we carried out comprehensive screening BRCA1/2, TP53 R337H, CHEK2 1100delC, followed by an analysis copy number variations 14 additional (PTEN, ATM, NBN, RAD50, RAD51, BRIP1, PALB2, MLH1, MSH2, MSH6, TP53, CDKN2A, CDH1 CTNNB1). Capillary...
Anthropogenic activities in tropical rivers favor the eutrophication process, which causes increased concentration of heavy metals. The presence and bioaccumulation metals are directly related to genotoxic damage aquatic organisms. Thus, we evaluated (Fe, Zn, Cr, Cu Al) performed toxicogenetic tests surface (S) bottom (B) water samples Poti river (Piaui/Brazil). Cytotoxicity genotoxicity were Allium cepa, micronucleus (MN) comet assay Oreochromis niloticus. chemical analysis showed...
Among the food additives used in industry, dyes are considered most toxic. For instance, tartrazine (TRZ) is a colorant commercially available with conflicting data regarding its cytotoxic, genotoxic, and mutagenic effects. Therefore, this study aimed to evaluate cytotoxic potential of TRZ using different eukaryotic cells (in vitro).This employed 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), brine shrimp lethality, Allium cepa Saccharomyces cerevisiae tests....
The chemotherapeutic drug doxorubicin (DOX) has been widely used for treating solid tumors attributed to its antiproliferative effectiveness; however, clinical use is limited due side effects, including cardiotoxicity, myelosuppression, and resistance. Combining DOX with buthionine sulfoximine (BSO), a glutathione (GSH) synthesis inhibitor, showed promising results in overcoming these adverse potentially reducing the required dose while maintaining efficacy. aim of present study was examine...
Abstract Background Patients with multiple colorectal adenomas are currently screened for germline mutations in two genes, APC and MUTYH . -mutated patients present classic or attenuated familial adenomatous polyposis (FAP/AFAP), while carrying biallelic exhibit MUTYH-associated (MAP). The spectrum of as well the genotype-phenotype correlations syndromes clinical impact can be population specific, making important to obtain genetic data from different populations. Methods DNA sequencing...
Alpha-terpineol is monoterpene alcohol with anti-tumor activity against different tumor cell lines (lung, breast, leukemias and colorectal) through blockage of NF-kB expression, which play an important role in cells growth.Evaluate the antitumor alpha-terpineol murine Sarcoma 180 line.For tests, cytotoxic genotoxic assays were used, including Trypan blue, cytokinesis- blocked micronucleus assay, comet agarose gel DNA fragmentation, flow cytometry viability using fluorescence. Ascitic fluid...
Lynch syndrome (LS) accounts for 3–5% of all colorectal cancers (CRC) and is inherited in an autosomal dominant fashion. This characterized by early CRC onset, high incidence tumors the ascending colon, excess synchronous/metachronous extra-colonic tumors. Nowadays, LS regarded patients who carry deleterious germline mutations one five mismatch repair genes (MMR), mostly MLH1 MSH2, but also MSH6, PMS1 PMS2. To comprehensively characterize 116 Brazilian suspected LS, we assessed frequency...
The present study evaluates the acute toxicity of synthetic grape, plum and orange flavourings in root meristem cells Allium cepa at doses 3.5, 7.0 14.0 mL/kg exposure times 24 48 h, bone marrow erythrocytes mice treated orally for seven days with 0.5, 1.0, 2.0, 5.0 10.0 flavouring. results plant test showed that flavourings, both times, inhibited cell division promoted formation a significant number micronuclei mitotic spindle changes. These alterations were observed least one time...
Considering the vast use of sweeteners by Brazilian population and constant need for toxicological studies food additives, this study aimed to evaluate cytotoxic mutagenic potentials sodium saccharin and/or cyclamate in plant (Allium cepa) animal (Mus musculus) test systems based on concentrations permitted laws. In A. cepa, both individually their combinations concentration exposure time (ET: 48, 72 168 h) dependently exerted effects. Similarly, an increased micronuclei formation was also...