A5102821294- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Function and Risk Factors
- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Heavy Metal Exposure and Toxicity
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Risk Factors
- Cardiovascular Disease and Adiposity
- Lipoproteins and Cardiovascular Health
- Arsenic contamination and mitigation
- Diet and metabolism studies
- Alcohol Consumption and Health Effects
- Sphingolipid Metabolism and Signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Cardiac electrophysiology and arrhythmias
- Fatty Acid Research and Health
- Obesity, Physical Activity, Diet
- Peroxisome Proliferator-Activated Receptors
- Cardiac Valve Diseases and Treatments
- Birth, Development, and Health
- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Cardiovascular Health and Disease Prevention
Kaiser Permanente
2025
MedStar Health
2014-2024
Georgetown-Howard Universities Center for Clinical and Translational Science
2013-2024
North Carolina Wildlife Resources Commission
2024
Georgetown University
2012-2017
Johns Hopkins University
2000-2015
MedStar Union Memorial Hospital
2002-2015
Cornell University
1996-2013
University of Graz
2012-2013
NewYork–Presbyterian Hospital
1996-2013
Background— The associations of low (<0.90) and high (>1.40) ankle brachial index (ABI) with risk all-cause cardiovascular disease (CVD) mortality have not been examined in a population-based setting. Methods Results— We CVD relation to ABI 4393 American Indians the Strong Heart Study. Participants had bilateral measurements at baseline were followed up for 8.3±2.2 years (36 589 person-years). Cox regression was used quantify rates among participants relative those normal (0.90 ≤ABI...
Whether diabetes mellitus (DM) adversely affects left ventricular (LV) structure and function independently of increases in body mass index (BMI) blood pressure is controversial.Echocardiography was used the Strong Heart Study, a study cardiovascular disease American Indians, to compare LV measurements between 1810 participants with DM 944 normal glucose tolerance. Participants were older (mean age, 60 versus 59 years), had higher BMI (32.4 28.9 kg/m(2)) systolic (133 124 mm Hg), more likely...
Background —Although cardiovascular disease (CVD) used to be rare among American Indians, Indian Health Service data suggest that CVD mortality rates vary greatly communities and appear increasing. The Strong Heart Study was initiated investigate its risk factors in Indians 13 Arizona, Oklahoma, South/North Dakota. Methods Results —A total of 4549 participants (1846 men 2703 women 45 74 years old) who were seen at the baseline (1989 1991) examination subjected surveillance (average 4.2...
OBJECTIVE—To determine whether non-HDL cholesterol, a measure of total cholesterol minus HDL is predictor CVD in patients with diabetes. RESEARCH DESIGN AND METHODS—The Strong Heart Study, population-based study and its risk factors 13 American Indian communities three geographic areas the U.S. The baseline examination, conducted between July 1989 January 1992, consisted personal interview, physical laboratory tests. Of 4,549 women men aged 45−74 years participating study, 2,108 had diabetes...
Cadmium is a widespread toxic metal with potential cardiovascular effects, but no studies have evaluated cadmium and incident disease. We the association of urine concentration disease incidence mortality in large population-based cohort.
Background: Long-term exposure to high levels of arsenic is associated with increased risk for cardiovascular disease, whereas from long-term low moderate (<100 µg/L in drinking water) unclear. Objective: To evaluate the association between and incident disease. Design: Prospective cohort study. Setting: The Strong Heart Study baseline visit 1989 1991, follow-up through 2008. Patients: 3575 American Indian men women aged 45 74 years living Arizona, Oklahoma, North South Dakota. Measurements:...
Abstract —Diabetes has been shown to increase the risk of coronary heart disease in all populations studied. However, there is a lack information on relative importance diabetes-associated factors for cardiovascular (CVD), especially role lipid levels, because low density lipoprotein (LDL) cholesterol often not elevated diabetic individuals. The objective this analysis was evaluate CVD large cohort individuals and compare dyslipidemia (ie, triglycerides levels high [HDL] cholesterol) LDL...
There are few data about the impact of recently-defined category prehypertension (systolic blood pressure 120 to 139 mm Hg or diastolic 80 89 Hg) on cardiovascular disease incidence. It is also unknown whether this association differs between individuals with without diabetes. A total 2629 Strong Heart Study participants free from hypertension and at baseline examination were followed for 12 years observe incident disease. Approximately 42% had We assessed prevalence hazard ratios associated...
Background —Although cardiac output (CO) plays the vital role of delivering nutrients to body tissues, few data are available concerning relations stroke volume (SV) and CO composition in large population samples. Methods Results —Doppler 2D echocardiography bioelectric impedance 2744 Strong Heart Study participants were used calculate SV relate them fat-free mass (FFM), adipose mass, demographic variables. Both higher men than women overweight normal-weight individuals, but these...
A method has been described for the measurement of apoB concentration and specific activity in very low density lipoprotein (VLDL) (LDL) during metabolic studies.For activity, was separated from other apolipoproteins lipids by precipitation in, subsequent washing with, isopropanol.For determination concentration, equal volumes isopropanol were mixed, protein content precipitate measured difference between total supernatant.Evidence that there no solubilization precipitated virtually free...
OBJECTIVE—Diabetes has been defined as a coronary heart disease (CHD) risk equivalent, and more aggressive treatment goals have proposed for diabetic patients. RESEARCH DESIGN AND METHODS—We studied the influence of single multiple factors on 10-year cumulative incidence fatal nonfatal CHD cardiovascular (CVD) in nondiabetic men women, with without baseline or CVD, population (n = 4,549) high prevalence diabetes. RESULTS—In both sexes, diabetes increased (hazard ratio 1.99 2.93...
The influence of obesity on the metabolism apolipoprotein B (apo B) in very low density lipoprotein (VLDL), intermediate (IDL), and (LDL) was investigated nine obese seven nonobese Pima Indian men. Kinetics VLDL-apo (VLDL-B), VLDL-triglycerides, IDL-B LDL-B were studied after injection autologous 131I-VLDL, [3H]glycerol, 125I-LDL. Specific activities measured apo isolated from all fractions triglyceride VLDL. Transport rates fractional catabolic for VLDL, IDL, LDL VLDL determined by...
Experimental studies suggest ceramides may play a role in insulin resistance. However, the relationships of circulating and related sphingolipids with plasma have been underexplored humans. We measured 15 ceramide sphingomyelin species fasting baseline samples from Strong Heart Family Study (SHFS), prospective cohort American Indians. examined sphingolipid associations both follow-up measures insulin, HOMA resistance (HOMA-IR), β-cell function (HOMA-B) after adjustment for risk factors....
OBJECTIVE Little is known about arsenic metabolism in diabetes development. We investigated the prospective associations of low-moderate exposure and with incidence Strong Heart Study. RESEARCH DESIGN AND METHODS A total 1,694 diabetes-free participants aged 45–75 years were recruited 1989–1991 followed through 1998–1999. used proportions urine inorganic (iAs), monomethylarsonate (MMA), dimethylarsinate (DMA) over their sum (expressed as iAs%, MMA%, DMA%) biomarkers metabolism. Diabetes was...
The American Heart Association's recommendations for optimal health, summarized in Life's Simple 7, have been associated with reduced risk of cardiovascular disease (CVD)-related end points, but no studies examined the association these goals incident type 2 diabetes, which is high CVD. purpose this analysis was to examine associations 7 diabetes among Indians, a population at cardiometabolic diseases.Strong Family Study participants without (n = 1,639) baseline and who participated...
Background: Epigenetic dysregulation has been proposed as a key mechanism for arsenic-related cardiovascular disease (CVD). We evaluated differentially methylated positions (DMPs) potential mediators on the association between arsenic and CVD. Methods: Blood DNA methylation was measured in 2321 participants (mean age 56.2, 58.6% women) of Strong Heart Study, prospective cohort American Indians. Urinary species were using high-performance liquid chromatography coupled to inductively plasma...
The association between prediabetes as currently defined and incident diabetes in populations with widespread obesity, insulin resistance syndrome, is not well defined. In this article, risk factors incidence rates American Indians (AI) are examined.A total of 1677 AI who were nondiabetic at baseline was examined during a median 7.8-year follow-up part the Strong Heart Study (SHS). Risk for measured. Prediabetes according to Diabetes Association 2003 criteria having impaired glucose...