A5081499416- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Arsenic contamination and mitigation
- Heavy Metal Exposure and Toxicity
- Health, Environment, Cognitive Aging
- Child Nutrition and Water Access
- Neonatal Respiratory Health Research
- Air Quality and Health Impacts
- Fluoride Effects and Removal
- Pregnancy and preeclampsia studies
- Food Security and Health in Diverse Populations
- Folate and B Vitamins Research
- Diabetes Management and Education
- Reproductive System and Pregnancy
- Homelessness and Social Issues
- Climate Change and Health Impacts
- Pregnancy and Medication Impact
- Child Abuse and Trauma
- COVID-19 Clinical Research Studies
- Energy and Environment Impacts
- COVID-19 and healthcare impacts
- Family and Disability Support Research
- Environmental Justice and Health Disparities
- Criminal Justice and Corrections Analysis
- Family Support in Illness
Stanford University
2023-2025
Stanford Medicine
2024-2025
Berkeley Public Health Division
2021-2023
Columbia University
2018-2023
University of California, Berkeley
2021-2023
Icahn School of Medicine at Mount Sinai
2020-2022
Ontario HIV Treatment Network
2015
McMaster University
2015
New York Academy of Medicine
2013-2014
The epigenetic effects of individual environmental toxicants in tobacco remain largely unexplored. Cadmium (Cd) has been associated with smoking-related health effects, and its concentration smoke is higher comparison other metals.
Rationale: Risk factors for coronavirus disease (COVID-19) mortality may include environmental exposures such as air pollution. Objectives: To determine whether, among adults hospitalized with PCR-confirmed severe acute respiratory syndrome 2 (SARS-CoV-2), long-term pollution exposure is associated the risk of mortality, ICU admission, or intubation. Methods: We performed a retrospective analysis SARS-CoV-2 PCR–positive patients admitted to seven New York City hospitals from March 8, 2020,...
Background: Epigenetic dysregulation has been proposed as a key mechanism for arsenic-related cardiovascular disease (CVD). We evaluated differentially methylated positions (DMPs) potential mediators on the association between arsenic and CVD. Methods: Blood DNA methylation was measured in 2321 participants (mean age 56.2, 58.6% women) of Strong Heart Study, prospective cohort American Indians. Urinary species were using high-performance liquid chromatography coupled to inductively plasma...
Abstract Background Epigenetic age acceleration (EAA) and epigenetic gestational (EGAA) are biomarkers of physiological development may be affected by the perinatal environment. The aim this study was to evaluate performance clocks identify biological sociodemographic correlates EGAA EAA at birth in childhood. In Project Viva pre-birth cohort, DNA methylation measured nucleated cells cord blood (leukocytes red cells, N = 485) leukocytes early (N 120, median 3.2 years) mid-childhood 460, 7.7...
Abstract Long-term exposure to ambient air pollution has been associated with epigenetic age acceleration (EAA) in adults, but its impact on children remains less understood. This study analyzed data from 457 (mean age: 7.9 years) the Project Viva cohort (2007-2010, eastern Massachusetts, USA). We calculated EAA leukocytes: Horvath’s Epigenetic Age Acceleration (HorvathEAA), Intrinsic (IEAA), and Skin Blood (Skin&BloodEAA). applied generalized additive models evaluate associations of...
Epigenetic clocks can serve as pivotal biomarkers linking environmental exposures with biological aging. However, research on the influence of epigenetic aging has largely been limited to a small number chemicals and specific populations. We harnessed data from National Health Nutrition Examination Survey 1999-2000 2001-2002 cycles examine exposome-wide associations between A total 8 were obtained whole blood in 2,346 participants ranging 50-84 years age. 64 including phthalates, metals,...
Arsenic exposure through drinking water persists in many regions. Inorganic As (InAs) is methylated to monomethyl-arsenical species (MMAs) and dimethyl-arsenical (DMAs), facilitating urinary excretion. methylation dependent on one-carbon metabolism, which influenced by nutritional factors such as folate creatine.This study investigated the effects of folic acid (FA) and/or creatine supplementation proportion metabolites urine.In a 24-wk randomized, double-blinded, placebo-controlled trial,...
Prenatal exposure to essential and non-essential metals impacts birth child health, including fetal growth neurodevelopment. DNA methylation (DNAm) may be involved in pathways linking prenatal metal health. In the Project Viva cohort, we analyzed extent which (As, Ba, Cd, Cr, Cs, Cu, Hg, Mg, Mn, Pb, Se, Zn) measured maternal erythrocytes were associated with differentially methylated positions (DMPs) regions (DMRs) cord blood tested if associations persisted collected mid-childhood. We...
This study examined whether children exposed to adversity would exhibit lower epigenetic age acceleration in the context of improved parenting. Children with developmental delays and externalizing behavior problems ( N = 62; M 36.26 months; 70.97% boys, 29.03% girls; 71% Latinx, 22.6% Black) were drawn from a larger randomized controlled trial (RCT), which them receive Internet-delivered parent–child interaction therapy (iPCIT; n 30) or community referrals as usual (RAU; 32). Epigenetic was...
Children with developmental delays are at a heightened risk of experiencing mental health challenges, and this is exacerbated among racially minoritized children who face disproportionate adversity. Understanding the impact parenting interventions on biological markers associated these risks crucial for mitigating long-term disparities. To examine effect 20 weeks an internet-based parent-child interaction training (iPCIT) program biomarkers aging chronic inflammation preschoolers delay...
Background: Chronic exposure to arsenic (As), a human toxicant and carcinogen, remains global public health problem. Health risks persist after As has ended, suggesting epigenetic dysregulation as mechanistic link between outcomes. Objectives: We investigated the association total urinary locus-specific DNA methylation in Strong Heart Study, cohort of American Indian adults with low-to-moderate [total As, mean (±SD) μg/g creatinine: 11.7 (10.6)]. Methods: was measured 2,325 participants...
Chronic arsenic (As) exposure is a global environmental health issue. Inorganic As (InAs) undergoes methylation to monomethyl (MMAs) and dimethyl-arsenical species (DMAs); full DMAs facilitates urinary excretion associated with reduced risk for As-related outcomes. Nutritional factors, including folate creatine, influence one-carbon metabolism, the biochemical pathway that provides methyl groups methylation.
Epigenetic gestational age acceleration (EGAA) at birth and epigenetic (EAA) in childhood may be biomarkers of the intrauterine environment. We investigated extent to which first-trimester folate, B
DNA methylation (DNAm) is vulnerable to dysregulation by environmental exposures during epigenetic reprogramming that occurs in embryogenesis. Sexual dimorphism environmentally induced DNAm has been identified and therefore it important understand sex-specific patterns. at several autosomal sites consistently associated with sex cord blood placental foetal tissues. However, there limited research comparing across tissues, particularly differentially methylated regions (DMRs). This study...
One-carbon metabolism (OCM), a biochemical pathway dependent on micronutrients including folate and vitamin B12, plays an essential role in aging-related physiological processes. DNA methylation-based aging biomarkers may be influenced by OCM. This study investigated associations of OCM-related with epigenetic the National Health Nutrition Examination Survey (NHANES). Blood methylation was measured adults aged ≥50 years 1999-2000 2001-2002 cycles NHANES. The following were included:...
Abstract Reproductive aging, including timing of menarche and menopause, influences long-term morbidity mortality in women, yet underlying biological mechanisms remain poorly understood. Using DNA methylation-based biomarkers, we assessed associations age at ( N = 1,033) menopause 658) with epigenetic aging a nationally representative sample women ≥ 50 years. Later was associated lower GrimAge deviation $$B$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>B</mml:mi>...
Background Immigrant status and citizenship influence health well-being, yet their associations with DNA methylation (DNAm)-based biomarkers of aging – key predictors healthspan lifespan, also known as epigenetic remain underexplored.
Abstract Background DNA methylation-based predictors of phenotypic traits including leukocyte proportions, smoking activity, biological aging, and circulating levels plasma proteins are widely used as biomarkers in public health research. However, limited racial ethnic diversity research participants is an ongoing issue for epigenetics research, the potential downstream impacts training samples on performance epigenetic remains poorly understood. We examined chronological age (also known...