A5076351020- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Blood Pressure and Hypertension Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiac Valve Diseases and Treatments
- Cardiovascular Health and Disease Prevention
- Parathyroid Disorders and Treatments
- Cardiac tumors and thrombi
- Cardiac electrophysiology and arrhythmias
- Heart Rate Variability and Autonomic Control
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- PARP inhibition in cancer therapy
- COVID-19 and healthcare impacts
- Childhood Cancer Survivors' Quality of Life
- Pericarditis and Cardiac Tamponade
- Integrated Circuits and Semiconductor Failure Analysis
- Advancements in Semiconductor Devices and Circuit Design
- Atrial Fibrillation Management and Outcomes
- Polymer Nanocomposite Synthesis and Irradiation
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cancer-related cognitive impairment studies
Cornell University
2007-2025
Memorial Sloan Kettering Cancer Center
2015-2025
Presbyterian Hospital
2003-2024
Weill Cornell Medicine
2024
Mayo Clinic in Arizona
2022
Mayo Clinic in Florida
2022
WinnMed
2022
New York Proton Center
2021
North Shore University Hospital
2007
Albert Einstein College of Medicine
2004
With aging, left ventricular filling tends to decrease in early diastole, reducing the mitral ratio of peak late diastolic velocity (E/A). However, prognostic significance low or high E/A older adults remains be elucidated population-based samples.Doppler echocardiograms were analyzed 3008 American Indian participants second Strong Heart Study examination who had no more than mild aortic regurgitation. Participants followed for a mean 3 years after Doppler echocardiography assess risks...
The discipline of Cardio-Oncology has seen tremendous growth over the past decade. It is devoted to cardiovascular (CV) care cancer patient, especially mitigation and management CV complications or toxicities therapies, which can have profound implications on prognosis. To that effect, many studies assessed in patients undergoing various types therapies; however, direct comparisons proven difficult due lack uniformity toxicity endpoints. Similarly, clinical practice, there be substantial...
Background: Ambulatory blood pressure may be higher or lower than clinic pressure. Attention has focused on “white coat hypertension” (normal ambulatory elevated in the clinic). The converse phenomenon of high but normal office pressure—“white normotension”—has not been studied. Objective: To assess whether white normotension (awake > 134/90 mm Hg and < 140/90 Hg) is associated with target organ damage. Design: Cross-sectional observational study. Setting: University hospital hypertension...
Background —Type 2 diabetes is a cardiovascular risk factor. It remains to be elucidated in large, population-based sample whether associated with changes left ventricular (LV) structure and systolic function independent of obesity blood pressure (BP). Methods Results —Among 1950 hypertensive participants the HyperGEN Study without overt coronary heart disease or significant valve disease, 20% (n=386) had diabetes. Diabetics were more likely women, black, older, have higher BMI waist/hip...
The degree to which ethnic differences in left ventricular structure among hypertensive adults are independent of clinical and hemodynamic factors remains uncertain. We assessed whether mass geometry differ between black white hypertensives after accounting for such factors. Our study group comprised 1060 580 participants free valvular or coronary disease a population-based cohort. Blood pressure was measured during clinic visit echocardiography performed using standardized protocols. After...
Racial and social disparities exist in outcomes related to cancer cardiovascular disease (CVD). The aim of this cross-sectional study was the impact vulnerability on mortality attributed comorbid CVD. Centers for Disease Control Prevention Wide-Ranging Online Data Epidemiologic Research database (2015-2019) used obtain county-level data cancer, CVD, County-level index (SVI) (2014-2018) were obtained from CDC’s Agency Toxic Substances Registry. SVI percentiles generated each county aggregated...
Chimeric antigen receptor T-cell therapy (CAR-T) harnesses a patient's immune system to target cancer. There are sparse existing data characterizing death outcomes after CAR-T-related cardiotoxicity. This study examines the association between severe cardiovascular events (SCE) and mortality.
Trastuzumab improves outcomes in patients with ERBB2-positive (formerly HER2) breast cancer but is associated treatment-induced cardiotoxicity, most commonly manifest by an asymptomatic decline left ventricular ejection fraction (LVEF). Little known to date regarding the long-term effects of cardiotoxicity on cardiopulmonary function who survive trastuzumab-treated cancer.To determine whether recovers or dysfunction survivors cancer.This cross-sectional case-control study enrolled...
Two-dimensional speckle tracking echocardiography (2DSTE) provides a sensitive measure of left ventricular (LV) systolic function and may aid in the diagnosis cardiotoxicity. 2DSTE was performed cross-sectional study 134 patients (mean age:<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn fontstyle="italic">31.4</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle="italic">8.8</mml:mn></mml:math>years; 55% male; mean time since diagnosis:<mml:math id="M2"><mml:mn...
Abstract Introduction. Myocardial strain imaging and blood biomarkers have been proposed as adjuncts to left ventricular ejection fraction (LVEF) monitoring for the early detection of cardiotoxicity during cancer therapy. We report results a preplanned cardiac safety analysis global longitudinal (GLS), troponin-I (TnI) brain natriuretic peptide (BNP) levels in phase II study paclitaxel, trastuzumab, pertuzumab (THP) metastatic HER2-positive breast cancer. Patients Methods. with 0–1 lines...
Advanced light-chain (AL) amyloidosis is associated with poor prognosis, a 5-year survival rate of <25%. Prognostication based on the revised Mayo (rMayo) staging according to serum cardiac biomarkers. This study sought determine whether global longitudinal strain (GLS) can provide incremental prognostic value in patients advanced disease. Baseline (pre-treatment) clinical, 2-dimensional echocardiogram GLS and laboratory data were collected prospectively 94 newly diagnosed AL rMayo stage III...