A5102952159- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Venous Thromboembolism Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Heart Rate Variability and Autonomic Control
- Cardiac Fibrosis and Remodeling
- Advanced Radiotherapy Techniques
- Cardiac Structural Anomalies and Repair
- Cell Adhesion Molecules Research
- Heart Failure Treatment and Management
- Effects of Radiation Exposure
- Galectins and Cancer Biology
- Receptor Mechanisms and Signaling
- Cardiac tumors and thrombi
- Lipoproteins and Cardiovascular Health
- Signaling Pathways in Disease
- Circular RNAs in diseases
- Blood Pressure and Hypertension Studies
- Health Systems, Economic Evaluations, Quality of Life
- Electrodeposition and Electroless Coatings
- Diabetes Treatment and Management
- Extracellular vesicles in disease
Wuhan General Hospital of Guangzhou
2025
Shandong Provincial QianFoShan Hospital
2006-2023
Shandong University
2007-2023
Shandong First Medical University
2023
Max Planck Institute for Heart and Lung Research
2016
Southern Medical University
2016
Nanjing Medical University
2011
Background A critical mechanism in atrial fibrillation (AF) is cardiac autonomic nerve remodeling (ANR). MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level. Numerous miRNAs involved diseases of nervous and cardiovascular systems. Objective We aimed to assess underlying role regulating ANR AF by right tachypacing (A-TP) canines. Methods Results Following 4-week A-TP, superior left ganglionated plexuses (SLGPs), which embedded fat pads...
BackgroundThe potential mechanisms of microRNA-1 (miR-1) in the electrical remodeling atrial fibrillation remain unclear. The purpose this study was to evaluate effects miR-1 on effective refractory period (AERP) a right tachypacing model and elucidate mechanisms. Methods ResultsQRT-PCR western blot were used detect expression miR-1, KCNE1, KCNB2 genes after 1-week New Zealand white rabbits. AERP measured using programmable multichannel stimulator, induced by burst stimulation vivo. slowly...
<title>Abstract</title> <italic><bold>Background</bold></italic><bold>: </bold>Static squats are widely used in the treatment of patellofemoral pain syndrome (PFPS), but no study has determined most effective static squat mode. This compared efficacies three modes rehabilitation patients with PFPS. <italic><bold>Methods</bold></italic><bold>: </bold>This studyrecruited 84 PFPS who were divided into four groups on basis different modes. The underwent a 6-week training period using mobile...
Studies showed that elevated preoperative serum uric acid(SUA) levels are associated with recurrence of atrial fibrillation(AF) after catheter ablation. UA:creatinine ratio(UCR - UA normalised for renal function) has appeared as a new biomarker and is considered to reflect endogenous preferably because it eliminates the influence function. This study aimed investigate correlation between UCR AF ablation.A total 233 consecutive patients symptomatic, drug-refractory underwent All participants...
Previous studies have shown a variation in plasma level of von Willebrand factor (vWF) acute myocardial infarction (AMI) patients but with contentious results. In this study, we performed meta-analysis to evaluate the kinetics vWF after AMI. A total 11 qualified were obtained through systematical search PubMed, Web science, Cochrane Library database and CNKI, followed by reference lists, involving 519 AMI 466 non-AMI controls. The standard mean difference (SMD) 95% confidence intervals (95%...
Coronary artery ligation is widely used for myocardial infarction (MI) induction in rats but produces a large variation infarct size — major determinant of mortality. Accurate control critically important the establishment useful animal model. This study determined anatomical course left anterior descending coronary (LAD) by direct visualization order to locate precisely position ligation. MI was induced conventional methods (control group) or using detailed knowledge LAD (experimental...
Background— The long-term effects of ganglionated plexi ablation on electrophysiological characteristics and neuron remodeling in target atrial tissues remain unclear. Methods Results— Dogs group 1 (control, n=8) were not subjected to observed for month, dogs groups 2 4 (ablation groups, n=8 each) underwent the right-sided 1, 6, 12 months, respectively. Atrial examined before ablation, immediately continuously after ablation. Target immunohistochemical staining Western blot analysis....
Background No evidence has been presented to show whether autonomic neural remodeling occurs in pulmonary vein‐left atrium (PV‐LA) junction and what an important role it may play AF. This study aims find out these issues a prolonged rapid atrial pacing canine model. Methods Twelve healthy mongrel dogs were randomly divided into two groups, six each: the paced group underwent right at 400 beats per minute for 4 weeks, control was not paced. The effective refractory period (ERP) of left...
The aim of this study was to detect early changes (within 1-4 h) in the brain natriuretic peptide (BNP) levels rats with acute myocardial infarction (AMI). A total 35 Wistar were established as models AMI and 30 sham-operated used control group. myocardia two groups observed using a transmission electron microscope (TEM) prior following surgery. double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) serum BNP cardiac troponin I (cTnI) concentrations before h after Following...
The aim of this study was to investigate the correlation between altered expression genes involved in regulation ion channels atrial myocytes and risk fibrillation (AF) patients with heart failure (HF). Right appendages were obtained from 18 HF normal cardiac functions who had undergone surgery. mRNA levels Kv4.3α, KvLQT1, Kv1.5, L-Caα1c NCX measured by reverse transcription-PCR (RT-PCR). Protein also detected western blotting. In comparison control group exhibiting functions, protein KvLQT1...
Cardiovascular disease (CAD) is a devastating illness, but to date there are limited means of predicting person's coronary stenosis severity and their prognosis. The study was performed investigate the relationship between dipeptidyl peptidase 4(DPP4) gene polymorphisms serum lipid profiles, as well artery in patients with CAD type 2 diabetes (T2DM) for first time.Herein, 201 T2DM were enrolled Department Cardiology, Shandong Provincial Qianfoshan Hospital. DPP4 rs3788979 rs7608798 single...
The present study aimed to investigate the effect of rosuvastatin on atrial structural remodeling in rabbits with myocardial infarction (MI). were randomly divided into 4 groups: sham operation group (S; n=8), MI (MI; n=7), low‑dose [Rs; 2.5 mg/(kg/d), n=7] and high‑dose [Rl, 5 n=8]. A rabbit model was established via ligation anterior descending coronary artery. After 8 weeks intervention, left diameter (LAD), collagen content, expression level type Ⅰ ventricular ejection fraction (LVEF)...
Radiation-induced heart disease (RIHD) is a common sequela of thoracic irradiation. At the same time, nerve remodeling involved in progression disease. However, activation related genes radiation-induced still lacking.In this study, C57BL/J mice was anesthetized by intraperitoneal injection with pentobarbital sodium (2%, 40 mg/kg), and radiation delivered using cobalt-60 (60Co) teletherapy unit (Cirus). When were anesthetized, none them showed signs peritonitis, pain, or discomfort. The...
Abstract A growing number of reports have shown that oxidative stress is an important contributing factor for atrial fibrillation (AF). The identification stress-related blood biomarkers patients with AF has great significance the early prevention and treatment AF. purpose this study was to illuminate relationship several markers This enrolled hospitalized from January 2018 December 2020 at Department Cardiology in a tertiary center east China.Clinical data, emphasis on biomarkers, were...
Objectives: We recently detected several isoforms of Reg proteins, distinctive subtypes C-type lectins, in dedifferentiating cardiomyocytes response to Oncostatin M signaling. Several migration assays provided evidence that the lectins have a great chemokinetic and chemotactic potential on immune cells. Genetic disruption Reg3b resulted after myocardial infarction (MI) increasing susceptibility cardiac rupture showed signs failure.