A5026733739- biodegradable polymer synthesis and properties
- Nanocomposite Films for Food Packaging
- Ferroptosis and cancer prognosis
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Supercapacitor Materials and Fabrication
- RNA modifications and cancer
- Lipid Membrane Structure and Behavior
- Ubiquitin and proteasome pathways
- Advanced Sensor and Energy Harvesting Materials
- MXene and MAX Phase Materials
- Additive Manufacturing and 3D Printing Technologies
- Peptidase Inhibition and Analysis
- Advancements in Transdermal Drug Delivery
- MicroRNA in disease regulation
- Supramolecular Self-Assembly in Materials
- Metal and Thin Film Mechanics
- Extracellular vesicles in disease
- Ginkgo biloba and Cashew Applications
- Cancer Mechanisms and Therapy
- Glioma Diagnosis and Treatment
- Advanced Cellulose Research Studies
- Down syndrome and intellectual disability research
- Neurological Disease Mechanisms and Treatments
Union Hospital
2024
Huazhong University of Science and Technology
2024
Shandong University of Science and Technology
2024
Nankai University
2019-2024
Nanchang University
2015-2022
Second Affiliated Hospital of Nanchang University
2015-2022
Yantaishan Hospital
2021
Shandong University of Traditional Chinese Medicine
2021
State Key Laboratory of Medicinal Chemical Biology
2019
State Key Laboratory of Chemical Engineering
2019
Glioblastoma multiforme (GBM) is the most common malignant brain tumor originating in central nervous system. Efficient delivery of therapeutic molecules to cells and tissues a difficult challenge.Arginine-glycine-aspartic acid peptide (RGD)-modified nanostructured lipid carriers (NLCs) were used for temozolomide (TMZ) into GBM provide new paradigm gliomatosis cerebri treatment.RGD-conjugated polyethylene glycol-b-distearoylphosphatidylethanolamine (PEG-DSPE) was synthesized. RGD containing,...
Abstract Although TiNb 2 O 7 (TNO) with comparable operating potential and ideal theoretical capacity is considered to be the most replacement for negative Li 4 Ti 5 12 (LTO), low ionic electronic conductivity still limit its practical application as satisfactory anode lithium‐ion batteries (LIBs) high‐power density. Herein, TNO nanoparticles modified by Cerium (Ce) outstanding electrochemical performance are synthesized. The successful introduction of Ce 3+ in lattice leads increased...
Noncovalent interactions involving aromatic rings, such as π-stacking and π-ion interactions, play an essential role in molecular recognition, assembly, catalysis, electronics. However, the inherently weak complex nature of these has made it challenging to study them experimentally, especially with regard elucidating their properties solution. Herein, noncovalent between π π-hole, cation, π-hole anion complexes nonpolar solution are investigated situ through single-molecule electrical...
Co-delivery of gene and anticancer drug into the same cancer cells or tissues by multifunctional nanocarriers may provide a new paradigm in treatment. In this study, nanostructured lipid carriers (NLCs) were constructed as nanomedicine for co-delivery enhanced green fluorescence protein plasmid (DNA) temozolomide (TMZ).TMZ- DNA-loaded NLCs (TMZ/DNA-NLCs) prepared. Their particle size, zeta potential, gene-loading capacity (GL) encapsulation efficiency (EE) evaluated. vitro cytotoxicity study...
Dynamic peptide hydrogels undergoing directional domain sliding movement upon release of covalent constraint accelerate cell proliferation through a mechanotransduction pathway.
Peptide interdigitation allows for precisely creating twisted nanoribbons driven by antiparallel β-sheet H-bonds, leading to chiral scaffolds supramolecular nanozymes.
Abstract A layer of SiO x was deposited on the surface poly(L‐lactic acid) (PLLA) film to fabricate a PLLA/SiO layered film, by plasma‐enhanced chemical vapor deposition (PECVD) process. showed Young's modulus and tensile strength increased 119.2% 91.6%, respectively, over those neat PLLA film. At 5 °C, oxygen (O 2 ) carbon dioxide (CO permeability decreased 78.7% 71.7%, CO /O permselectivity 32.5%, compared that When applied equilibrium‐modified atmosphere packaging chilled meat, gas...
Aim to modify the poly(l-lactic acid) (PLLA) make it better applications in food packing and evaluate effect of some antimicrobials meat packaging storage, PLLA/poly(vinyl alcohol)/poly(ε-caprolactone) (PLLA/PVA/PCL, LVC) multilayer film with antimicrobial, such as tea polyphenols (TP), potassium sorbate (PS), trehalose (TH) were prepared by laminating technique potentially used for chilled meat, significantly improved mechanical properties barrier property PLLA. Total viable count (TVC)...
Background: Cell cycle is critical for a wide range of cellular processes such as proliferation, differentiation and apoptosis in dividing cells. Neurons are postmitotic cells which have withdrawn from the cell division cycle. Recent data show us that inappropriate activation regulators including cyclins, cyclin dependent kinases (CDKs) endogenous kinase inhibitors (CDKIs) may take part aetiology neurodegenerative diseases. However, mechanisms reentry disease remain unclear.Methods:...
In this work, poly(L-lactic acid) film was coated with SiOx by the plasma-enhanced chemical vapor deposition different times. Compared neat film, oxygen (O2), carbon dioxide (CO2), nitrogen (N2), and water permeability of acid)/SiOx60 (depositing for 60 min) decreased 40.7, 30.6, 58.7, 53.4% at 25°C, respectively. After treated deposition, gas permselectivity such as α(CO2/O2), α(O2/N2), α(CO2/N2), increased 17.2, 43.9, 67.5% addition, Young’s modulus tensile strength 107.2 49.3%, Moreover,...
Glioma is a well‑known aggressive and malignant brain tumor, accounts for ~30% of all central nervous system tumors. A number studies have indicated that the abnormal expression specific microRNAs (miR) serves vital roles in tumorigenesis tumor development human cancer, including glioma. miR‑216b has been studied types cancer. However, pattern, molecular function underlying mechanisms glioma remain unclear. In present study, it was demonstrated level significantly decreased tissues cell...
To investigate the role and mechanism of protein kinase R (PKR) in subarachnoid hemorrhage (SAH)-mediated ferroptosis. A rat SAH model was constructed treated with PKR inhibitor C16 to observe neurological impairment rats detect malonaldehyde (MDA), iron ions content, ferritin heavy polypeptide 1 (FTH1) glutathione peroxidase 4 (GPX4), other related ferroptosis indicators brain tissue. RNA sequencing analysis used PKR, affecting network SAH. caused severe fundic hemorrhage, impairment, MDA...
The poly( ε-caprolactone)/silicon oxide (PCL/SiO x )-coated film was prepared by plasma-enhanced chemical vapor deposition of SiO . result showed that the PCL/SiO presented increased elongation at break and appropriate gas permeability CO 2 /O permselectivity. further used for window packing container equilibrium-modified atmosphere packaging fresh cherry tomato. composition within containers depended on respiration tomato, which finally reached steady states 4–6% 11–13% O room temperature...
Although genome-wide association studies (GWASs) have identified dozens of loci associated with colorectal cancer (CRC) susceptibility, the causal genes or risk variants within these and their biological functions often remain elusive. Recently, genomic locus 12p13.32, tag SNP rs10774214, was as a crucial CRC in Asian populations. However, functional mechanism this region has not been fully elucidated. Here, we applied high-throughput RNA interference (RNAi) approach cell lines to...
Up to now, the mainstream adoption of renewable energy has brought about substantial transformations in electricity and sector. This shift garnered considerable attention within scientific community. Supercapacitors, known for their exceptional performance metrics like good charge/discharge capability, strong power density, as well extended cycle longevity, have gained widespread traction across various sectors, including transportation aviation. Metal-organic frameworks (MOFs) with unique...
Genome-wide association studies (GWAS) have identified over 150 risk loci linked to colorectal cancer (CRC), including the 17p13.3 locus with tag single nucleotide polymorphism (SNP) rs12603526 in Asian population. However, specific causal gene and functional regulatory mechanisms this region remain unresolved, necessitating further investigation elucidate underlying of CRC. We employed an RNA interference-based approach identify genes critical for CRC cell proliferation at GWAS 17p13.3....
Objective: Increasing evidence emphasizes the clinical implications of RNA binding proteins (RBPs) in cancers. This study aimed to develop a RBP signature for predicting prognosis glioma. Methods: Two glioma datasets as training ( n = 693) and validation 325) sets were retrieved from CGGA database. In set, univariate Cox regression analysis was conducted screen prognosis-related RBPs based on differentially expressed between WHO grade II IV. A ten-RBP then established. The predictive...