A5072085443- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Lymphoma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Medical Imaging Techniques and Applications
- Lung Cancer Treatments and Mutations
- Radiation Detection and Scintillator Technologies
- Chemotherapy-induced cardiotoxicity and mitigation
- Glioma Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Cardiac tumors and thrombi
- Advanced X-ray and CT Imaging
- Sarcoma Diagnosis and Treatment
- Radiation Dose and Imaging
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Imaging and Diagnostics
- Radiation Effects and Dosimetry
- Prostate Cancer Treatment and Research
- Neuroblastoma Research and Treatments
- Vascular Tumors and Angiosarcomas
- Radiation Effects in Electronics
- Hepatocellular Carcinoma Treatment and Prognosis
- Meningioma and schwannoma management
- Ocular Oncology and Treatments
Emory University
2019-2024
Children's Oncology Group
2024
NRG Oncology
2024
Emory and Henry College
2024
Emory Healthcare
2020-2021
Winship Cancer Institute
2020
University of Florida
2010-2019
University of Florida Health
2010-2019
Florida College
2010-2019
University Hospital Carl Gustav Carus
2018
Proton therapy offers superior low and intermediate radiation dose distribution compared with photon-based for brain skull base tumors; yet tissue within adjacent to the target volume may receive a comparable dose. We investigated tolerance of pediatric brainstem proton identified prognostic variables.All patients < 18 years old tumors or treated from 2007 2013 were reviewed; 313 who received > 50.4 CGE included in this study. Brainstem toxicity was graded according NCI Common Terminology...
Dose uncertainty induced by respiratory motion remains a major concern for treating thoracic and abdominal lesions using particle beams. This Task Group report reviews the impact of tumor dosimetric considerations in radiotherapy, current motion-management techniques, limitations different particle-beam delivery modes (i.e., passive scattering, uniform scanning, pencil-beam scanning). Furthermore, provides guidance risk analysis quality assurance procedures to ensure consistency accuracy,...
The purpose of this study is to accurately estimate the difference between planned and delivered dose due respiratory motion free breathing helical CT artefacts for lung IMRT treatments, impact on clinical outcome. Six patients with representative tumour motion, size position were selected retrospective study. For each patient, we had acquired both a ten-phase 4D-CT scan. A commercial treatment planning system was used create four plans patient. first two based GTV as contoured set, PTV...
PurposeMean heart dose (MHD) correlates with late cardiac toxicity among survivors of lymphoma receiving involved-field radiation therapy (IFRT). We investigated MHD and substructure across older newer fields techniques to understand the value evaluating alone.Methods MaterialsAfter institutional review board approval, we developed a database dosimetry plans for 40 patients mediastinal lymphoma, which included IFRT (anterior-posterior posterior-anterior), involved-site (ISRT) + 3-dimensional...
PurposeThis study describes the early clinical outcomes of a prospective phase 2 consolidative involved-node proton therapy (INPT) as component combined-mode in patients with stages I to III Hodgkin lymphoma (HL) mediastinal involvement.Methods and MaterialsBetween September 2009 June 2013, 15 newly diagnosed HL received INPT after completing chemotherapy an institutional review board-approved protocol comparing dosimetric impact PT those three-dimensional conformal radiation (3DCRT)...
We investigated early outcomes for patients receiving chemotherapy followed by consolidative proton therapy (PT) the treatment of Hodgkin lymphoma (HL).From June 2008 through August 2015, 138 with HL enrolled on either IRB-approved tracking protocols or registry studies received PT. Patients were excluded due to relapsed refractory disease. Involved-site radiotherapy field designs used all patients. Pediatric a median dose 21 Gy(RBE) [range 15-36 Gy(RBE)]; adult 30.6 [range, 20-45 Gy(RBE)]....
Study goals were to characterize gastrointestinal effects of proton therapy (PT) in a large cohort patients treated for prostate cancer, identify factors associated with rectal bleeding (RB), and compare RB between receiving investigational protocols versus those outcome-tracking protocols.A total 1285 consecutive PT August 2006 May 2010. Potential pre-existing clinical treatment-related risk toxicity recorded. Common Terminology Criteria Adverse Events version 3.0 was used score...
Background: For tumours near organs at risk, there is concern about unintended increase in biological dose from elevated linear energy transfer (LET) the distal end of treatment fields. The objective this study was therefore to investigate how different paediatric posterior fossa tumour locations impact LET and brainstem during intensity-modulated proton therapy (IMPT).Material methods: Multiple IMPT plans were generated for four simulated relative a five-year-old male patient. A prescribed...
In radiotherapy practice, one often needs to compare two dose distributions. Especially with the wide clinical implementation of intensity-modulated radiation therapy, software tools for quantitative (or fluence) distribution comparison are required patient-specific quality assurance. Dose is not a trivial task since it has be performed in both and spatial domains order clinically relevant. Each existing methods its own strengths weaknesses there room improvement. this work, we developed...
To report 5-year outcomes of a prospective trial image-guided accelerated hypofractionated proton therapy (AHPT) for prostate cancer.215 cancer patients accrued to institutional review board-approved 70Gy(RBE) in 28 fractions low-risk disease (n = 120) and 72.5Gy(RBE) 29 intermediate-risk 95). This excluded with volumes ≥60 cm3 or International Prostate Symptom Scores (IPSS) ≥15, on anticoagulants alpha-blockers, whom dose-constraint goals organs at risk (OAR) could not be met. Toxicities...