A5089346018- Advanced Causal Inference Techniques
- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Statistical Methods and Inference
- Health Systems, Economic Evaluations, Quality of Life
- Radiation Detection and Scintillator Technologies
- Statistical Methods in Clinical Trials
- Radiation Dose and Imaging
- Infrared Thermography in Medicine
- Photoacoustic and Ultrasonic Imaging
- Statistical Methods and Bayesian Inference
- Particle accelerators and beam dynamics
- Laser Applications in Dentistry and Medicine
- Advanced Statistical Process Monitoring
- Seismic Performance and Analysis
- Seismic Waves and Analysis
- Healthcare and Venom Research
- Advanced X-ray and CT Imaging
- X-ray Spectroscopy and Fluorescence Analysis
- Statistical Distribution Estimation and Applications
- Structural Health Monitoring Techniques
- Nuclear Physics and Applications
- Photocathodes and Microchannel Plates
- Radioactive Decay and Measurement Techniques
- Traditional Chinese Medicine Studies
Center for Devices and Radiological Health
2022-2025
United States Food and Drug Administration
2022-2025
Johns Hopkins University
2022-2024
The University of Texas MD Anderson Cancer Center
2019
Guangxi University
2012
China Earthquake Administration
2011
Shanghai University of Traditional Chinese Medicine
2008-2009
Dose uncertainty induced by respiratory motion remains a major concern for treating thoracic and abdominal lesions using particle beams. This Task Group report reviews the impact of tumor dosimetric considerations in radiotherapy, current motion-management techniques, limitations different particle-beam delivery modes (i.e., passive scattering, uniform scanning, pencil-beam scanning). Furthermore, provides guidance risk analysis quality assurance procedures to ensure consistency accuracy,...
ABSTRACT The method of power prior has long been used as a tool for leveraging external data to augment traditional clinical study. More recently, it found that integrating propensity scoring into its application the potential improved operating characteristics. In this paper, we introduce new score‐integrated strategy which uses score weighting and is distinctive from other such proposals in literature. This replaces sufficient statistic original expression with weighted version it. A...
Abstract The document ICH E9 (R1) has brought much attention to the concept of estimand in clinical trials community. stands for International Conference Harmonization. In this article, we draw one facet that is not discussed but crucial context observational studies, namely weighting covariate balance. How schemes are connected estimand, or more specifically its five attributes identified (R1), attribute population, illustrated using Rubin Causal Model. Three estimands examined from both...
Abstract The breakthrough propensity score methodology was formulated by Rosenbaum and Rubin in the 1980s for mitigation of confounding bias non‐randomized comparative studies to facilitate causal inference treatment effects. had been used mainly epidemiological social science that may often be exploratory, until it adopted FDA/CDRH 2002 applied evaluation medical device pre‐market confirmatory studies, including those with a control group extracted from well‐designed executed registry...
In a randomized controlled trial with time-to-event endpoint, some commonly used statistical tests to test for various aspects of survival differences, such as probability at fixed time point, function up specific and restricted mean time, may not be directly applicable when external data are leveraged augment an arm (or both arms) RCT. this paper, we propose propensity score-integrated approach extend leveraged. Simulation studies conducted evaluate the operating characteristics three...
Baseline offset in digital strong-motion acceleration record and initial velocity can produce unrealistic results for ground displacement derived from the by integration. A new method is proposed baseline correction calculation. It based on linear least-squares fitting of pre-event portion uncorrected data. Compared with conventional method, which removing mean values portions traces, this has clearer physical meaning better stability.
This study is part of ongoing efforts aiming to transit from measurement-based combined patient-specific quality assurance (PSQA) in intensity-modulated proton therapy (IMPT). A Monte Carlo (MC) dose-calculation algorithm used improve the independent dose calculation and reveal beam modeling deficiency analytical pencil (PB) algorithm.A set representative clinical IMPT plans with suboptimal PSQA results were reviewed. Verification recalculated using an MC developed in-house. Agreements PB...
In order to improve the accuracy of accelerator mass spectrometry (AMS) measurement for 182Hf/180Hf, a series measurements have been taken in AMS laboratory at China Institute Atomic Energy (CIAE). The major ones include instantaneous monitoring 180HfF−5 current, testing stability transmission, alternate an unknown sample and standard, origin identification minimization background 182W. experimental details improvement accuracy, as well some useful suggestions better satisfying requirements...
Objective: To compare the difference of body surface infrared radiation (IR) spectrum between point Qimen (LR14), Danzhong (CV17) and non-acupoint control patients with hyperplasia mammary gland (HMG). Methods: Sixty-eight HMG were enrolled in this trail. The left right detected by high-sensitive PHE201 spectrometer, wavelength from 1.5 m to 16 used. Results: There 49 wavelengths (3.50, 4.00, 4.50~16.00 m) among 59 wavelengths, IR intensity (LR14) was significantly higher than that (p<0.05)....
Abstract The propensity score‐integrated composite likelihood (PSCL) method is one that can be utilized to design and analyze an application when real‐world data (RWD) are leveraged augment a prospectively designed clinical study. In the PSCL, strata formed based on scores (PS) such similar subjects in terms of baseline covariates from both current study RWD sources placed same stratum, then applied down‐weight information RWD. While PSCL was originally proposed for fixed design, it extended...
Abstract In the area of diagnostics, it is common practice to leverage external data augment a traditional study diagnostic accuracy consisting prospectively enrolled subjects potentially reduce time and/or cost needed for performance evaluation an investigational device. However, statistical methods currently being used such leveraging may not clearly separate design and outcome analysis, they adequately address possible bias due differences in clinically relevant characteristics between...