A5063546647- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Radiation Detection and Scintillator Technologies
- Glioma Diagnosis and Treatment
- Atomic and Subatomic Physics Research
- Nuclear Physics and Applications
- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- Radiation Effects in Electronics
- Boron Compounds in Chemistry
- Effects of Radiation Exposure
- Childhood Cancer Survivors' Quality of Life
- Head and Neck Cancer Studies
- Brain Metastases and Treatment
- Radiation Dose and Imaging
- Photoreceptor and optogenetics research
- Medical Imaging Techniques and Applications
- Mitochondrial Function and Pathology
- Prostate Cancer Treatment and Research
- Head and Neck Surgical Oncology
- Traumatic Brain Injury and Neurovascular Disturbances
- Prostate Cancer Diagnosis and Treatment
- Advanced Electron Microscopy Techniques and Applications
- Meningioma and schwannoma management
University of Bergen
2015-2025
Haukeland University Hospital
2015-2024
Helmholtz-Zentrum Dresden-Rossendorf
2016-2018
OncoRay
2016-2018
National Center for Oncological Hadrontherapy
2018
Ospedale Santa Maria
2018
University of Glasgow
2016
Beatson West of Scotland Cancer Centre
2016
University Hospital of Zurich
2016
University Hospital Carl Gustav Carus
2016
The relative biological effectiveness (RBE) of protons varies with multiple physical and factors. Phenomenological RBE models have been developed to include such factors in the estimation a variable RBE, contrast clinically applied constant 1.1. In this study, eleven published phenomenological two plan-based were explored simulated patient cases. All analysed respect distribution range linear energy transfer (LET) reference radiation fractionation sensitivity ((α/β) x ) their respective...
Abstract Background The dose‐averaged linear energy transfer (LET D ) in proton therapy (PT) has pre‐clinical studies been linked to the relative biological effectiveness (RBE) of protons. Until recently, most common PT delivery method prostate cancer double‐scattered PT, with LET only available through dedicated Monte Carlo (MC) simulations. However, as relationship between and RBE double scattered have focused on head neck region, existing MC implementations not capable calculating for...
Background. Improvement in radiotherapy during the past decades has made risk of developing a radiation-induced secondary cancer as result dose to normal tissue highly relevant survivorship issue. Important factors expected influence include level and heterogeneity, well gender type irradiated. The elevated radio-sensitivity children calls for models particularly tailored paediatric patients.Material methods. Treatment plans six medulloblastoma patients were analysed with respect following...
Purpose The relative biological effectiveness (RBE) of protons varies with the radiation quality, quantified by linear energy transfer (LET). Most phenomenological models employ a dependency dose-averaged LET (LETd) to calculate dose. However, several experiments have indicated possible non-linear trend. Our aim was investigate if dose including dependencies should be considered, introducing spectrum based model. Method RBE-LET relationship investigated fitting polynomials from 1st 5th...
Background: For tumours near organs at risk, there is concern about unintended increase in biological dose from elevated linear energy transfer (LET) the distal end of treatment fields. The objective this study was therefore to investigate how different paediatric posterior fossa tumour locations impact LET and brainstem during intensity-modulated proton therapy (IMPT).Material methods: Multiple IMPT plans were generated for four simulated relative a five-year-old male patient. A prescribed...
Background: Proton arc therapy may improve physical dose conformity and reduce concerns of elevated linear energy transfer (LET) relative biological effectiveness (RBE) at the end proton range, while offering more degrees freedom for normal tissue sparing. To explore potential therapy, we studied effect increasing number beams on biologically equivalent in setting pediatric brain tumors. Material methods: A cylindrical phantom (Ø = 150 mm) with central targets 25 30 was planned equiangular...
Intensity modulated proton therapy (IMPT) could yield high linear energy transfer (LET) in critical structures and increased biological effect. For head neck cancers at the skull base this potentially result radiation-associated brain image change (RAIC). The purpose of current study was to investigate voxel-wise dose LET correlations with RAIC after IMPT.For 15 patients IMPT, contrast enhancement observed on T1-weighted magnetic resonance imaging contoured coregistered planning computed...
The on-line event reconstruction in ALICE is performed by the High Level Trigger, which should process up to 2000 events per second proton-proton collisions and 300 central heavy-ion collisions, corresponding an input data stream of 30 GB/s. In order fulfill time requirements, a fast tracker has been developed. algorithm combines Cellular Automaton method being used for pattern recognition Kalman Filter fitting found trajectories final track selection. was adapted run on Graphics Processing...
In order to determine the relative biological effectiveness (RBE) of protons with high accuracy, radiobiological experiments detailed knowledge linear energy transfer (LET) are needed. Cell survival data from LET sparse and low achieve values therefore required. The aim this study was quantify distributions a proton beam by using Monte Carlo (MC) simulations, further compare representing typical minimum available at clinical facilities.A Markus ionization chamber Gafchromic films were...
Background and PurposeRadiation-induced brainstem necrosis after proton therapy is a severe toxicity with potential association to uncertainties in the relative biological effectiveness (RBE). A constant RBE of 1.1 assumed clinically, but known vary linear energy transfer (LET). LET-inclusive predictive models may therefore be beneficial during treatment planning. Hence, we aimed construct describing between risk LET brainstem.Materials MethodsA matched case-control cohort (n=28, 1:3 ratio)...
Abstract Objective. While a constant relative biological effectiveness (RBE) of 1.1 forms the basis for clinical proton therapy, variable RBE models are increasingly being used in plan evaluation. However, there is substantial variation across models, and several new vitro datasets have not yet been included existing models. In this study, an updated database was collected to examine current model assumptions, propose up-to-date as tool evaluating effects settings. Approach. A (471 data...
The increased linear energy transfer (LET) at the end of Bragg peak causes concern for an elevated and spatially varying relative biological effectiveness (RBE) proton therapy (PT), often in or close to dose-limiting normal tissues. In this study, we investigated dose-averaged LET (LETd) distributions spot scanning PT prostate cancer patients using different beam angle configurations. addition, derived RBE-weighted (RBEw) dose related tissue complication probabilities (NTCPs) rectum...
An elevated risk of radiation-induced secondary cancer (SC) has been observed in prostate patients after radiotherapy (RT), rising to as high one 70 with more than 10 years follow-up. In this study we have estimated SC risks following RT both previous and contemporary techniques, including proton therapy, using models based on different dose-response relationships.RT plans treating the seminal vesicles either conformal (CRT), volumetric modulated arc therapy (VMAT) or intensity-modulated...
Proton arc therapy (PAT) is currently explored for clinical implementation, despite its associated low-dose bath. This study therefore aimed at evaluating the risk of radiation-induced second primary cancer (SPC) PAT in pediatric brain tumor patients. Two brain-specific models SPC induction were applied five cases to compare volumetric modulated (VMAT), intensity proton (IMPT) and surrogate plans. The integral dose was reduced by a median 29% compared VMAT, 17% IMPT. For both models,...
Background: Children with brain tumors undergoing radiotherapy are at particular risk of radiation-induced morbidity and therefore routinely considered for proton therapy (PT) to reduce the dose healthy tissues. The aim this study was apply pediatric constraints normal tissue complication probability (NTCP) models when evaluating differences between PT contemporary photon-based radiotherapy, volumetric modulated arc (VMAT).Methods: Forty patients (aged 1–17 years) referred from Norwegian...
Background: Several brain substructures associated with cognition (BSCs) are located close to typical pediatric tumors. Pediatric patients therefore have considerable risks of neurocognitive impairment after radiotherapy. In this study, we investigated the radiation doses received by BSCs for three common locations tumor entities.Material and methods: For ten in each group [posterior fossa ependymoma (PFE), craniopharyngioma (CP), hemispheric (HE)], cumulative fraction volumes receiving...
IntroductionThe increased radioresistance of hypoxic cells compared to well-oxygenated is quantified by the oxygen enhancement ratio (OER). In this study we created a FLUKA Monte Carlo based tool for inclusion both OER and relative biological effectiveness (RBE) in biologically weighted dose (ROWD) calculations proton therapy applied explore impact hypoxia.MethodsThe RBE-weighted was adapted hypoxia making RBE model parameters dependent on OER, addition linear energy transfer (LET). The...
However, I would first
Introduction Proton arc therapy (PAT) is an emerging treatment modality that holds promise to improve target volume coverage and reduce linear energy transfer (LET) in organs at risk. We aimed investigate if pruning the highest layers each beam direction could increase LET tissue risk (OAR) surrounding volume, thus reducing relative biological effectiveness (RBE)-weighted dose sparing healthy tissue. Methods PAT plans for a germinoma, ependymoma rhabdomyosarcoma patient were created Eclipse...