A5020301757- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Atomic and Subatomic Physics Research
- Nuclear Physics and Applications
- Mitochondrial Function and Pathology
- Medical Imaging Techniques and Applications
- Radiation Effects in Electronics
- Cancer, Hypoxia, and Metabolism
- Advanced NMR Techniques and Applications
- Family Support in Illness
- Ethics and Legal Issues in Pediatric Healthcare
- Childhood Cancer Survivors' Quality of Life
- Lung Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Radiation Effects and Dosimetry
- Electron Spin Resonance Studies
- Radiation Detection and Scintillator Technologies
- Radiomics and Machine Learning in Medical Imaging
- Metabolism and Genetic Disorders
- Boron Compounds in Chemistry
University of Bergen
2020-2025
St Olav's University Hospital
2023
Cancer Clinic
2023
Haukeland University Hospital
2023
Norwegian University of Science and Technology
2023
Background and purpose: Proton Arc Therapy (PAT) is an emerging proton therapy treatment modality with the potential to reduce radiation exposure healthy tissues compared conventional Intensity-Modulated (IMPT) fewer beams. This attractive option for treating pediatric patients, who are vulnerable radiation-induced side effects. There is, however, a need investigate redistribution of dose target volume organs at risk. In this study, we therefore explored PAT in ependymoma. Methods materials:...
Abstract Objective. While a constant relative biological effectiveness (RBE) of 1.1 forms the basis for clinical proton therapy, variable RBE models are increasingly being used in plan evaluation. However, there is substantial variation across models, and several new vitro datasets have not yet been included existing models. In this study, an updated database was collected to examine current model assumptions, propose up-to-date as tool evaluating effects settings. Approach. A (471 data...
IntroductionThe increased radioresistance of hypoxic cells compared to well-oxygenated is quantified by the oxygen enhancement ratio (OER). In this study we created a FLUKA Monte Carlo based tool for inclusion both OER and relative biological effectiveness (RBE) in biologically weighted dose (ROWD) calculations proton therapy applied explore impact hypoxia.MethodsThe RBE-weighted was adapted hypoxia making RBE model parameters dependent on OER, addition linear energy transfer (LET). The...
Introduction Proton arc therapy (PAT) is an emerging treatment modality that holds promise to improve target volume coverage and reduce linear energy transfer (LET) in organs at risk. We aimed investigate if pruning the highest layers each beam direction could increase LET tissue risk (OAR) surrounding volume, thus reducing relative biological effectiveness (RBE)-weighted dose sparing healthy tissue. Methods PAT plans for a germinoma, ependymoma rhabdomyosarcoma patient were created Eclipse...
Abstract Introduction Tumor hypoxia is associated with poor treatment outcome. Hypoxic regions are more radioresistant than well‐oxygenated regions, as quantified by the oxygen enhancement ratio (OER). In optimization of proton therapy, including OER in addition to relative biological effectiveness (RBE) could therefore be used adapt patient‐specific radioresistance governed intrinsic radiosensitivity and hypoxia. Methods A combined RBE weighted dose (ROWD) calculation method was implemented...
Abstract In proton therapy, a constant relative biological effectiveness (RBE) factor of 1.1 is applied although the RBE has been shown to depend on factors including Linear Energy Transfer (LET). The radiotherapy also level oxygenation, quantified by oxygen enhancement ratio (OER). To estimate across different levels oxygenation RBE-OER-weighted dose (ROWD) can be used. investigate consistency between approaches ROWD, we implemented and compared OER models in Monte Carlo (MC) simulation...
Image-driven dose escalation to tumor subvolumes has been proposed improve treatment outcome in head and neck cancer (HNC). We used 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) acquired at baseline into (interim) identify biologic target volumes (BTVs). assessed the feasibility of interim BTV with proton therapy by simulating effects organs risk (OARs). semiautomated just-enough-interaction (JEI) method BTVs 18F-FDG-PET images from nine HNC patients. Between FDG-PET,...
<title>Abstract</title> Background Image-driven dose escalation to tumor subvolumes has been proposed improve treatment outcome in head and neck cancer (HNC). We used <sup>18</sup>F-fluorodeoxyglucose (FDG) positron emission tomography (PET) acquired at baseline two-three weeks into (interim) identify biologic target volumes (BTV). assessed the feasibility of interim BTV with proton therapy by simulating effects organs risk (OARs). Methods semiautomated just-enough-interaction (JEI) method...