A5029756439- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Cancer Genomics and Diagnostics
- Neuroblastoma Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Neurofibromatosis and Schwannoma Cases
- Radiation Therapy and Dosimetry
- Bone Tumor Diagnosis and Treatments
- MRI in cancer diagnosis
- Epigenetics and DNA Methylation
- Sarcoma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Chromatin Remodeling and Cancer
- Spinal Dysraphism and Malformations
- Childhood Cancer Survivors' Quality of Life
- RNA modifications and cancer
- Management of metastatic bone disease
- Vascular Malformations Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Tumors and Oncological Cases
- MicroRNA in disease regulation
- Oral and Maxillofacial Pathology
- Acute Myeloid Leukemia Research
- Medical Imaging Techniques and Applications
Oslo University Hospital
2016-2025
Cancer Genetics (United States)
2019-2023
University of Oslo
2011-2020
Norwegian Cancer Society
2003-2017
Rigshospitalet
2015
Infant high-grade gliomas appear clinically distinct from their counterparts in older children, indicating that histopathologic grading may not accurately reflect the biology of these tumors. We have collected 241 cases under 4 years age, and carried out histologic review, methylation profiling, custom panel, genome, or exome sequencing. After excluding tumors representing other established entities subgroups, we identified 130 to be part an "intrinsic" spectrum disease specific infant...
Abstract Background No systemic treatment has been established for meningioma progressing after local therapies. Methods This randomized, multicenter, open-label, phase II study included adult patients with recurrent WHO grade 2 or 3 meningioma. Patients were 2:1 randomly assigned to intravenous trabectedin (1.5 mg/m2 every weeks) standard of care (LOC). The primary endpoint was progression-free survival (PFS). Secondary endpoints comprised overall (OS), objective radiological response,...
Abstract Chromosome banding as well molecular cytogenetic methods are of great help in the diagnosis mesenchymal tumors. Myoepithelial neoplasms soft tissue including myoepitheliomas, mixed tumors, and parachordomas diagnoses that have been increasingly recognized last few years. It is still debated which should be included these morphologically heterogeneous entities, boundaries between them not clear‐cut. The pathogenetic mechanisms behind myoepithelial tumors unknown. Only five one tumor...
Abstract Myoepithelial neoplasms of soft tissue have only recently been acknowledged as a separate diagnostic entity. To know based on histological appearance whether these tumors are benign or malignant is often difficult, and their tumorigenic mechanisms remain poorly understood. We report myoepithelial carcinoma with an aberrant near‐diploid karyotype, 43∼47,XX,add(1)(p34)x2,add(3)(q27)x2,del(12)(q22),+add(18)(p11)x2,del(22)(q11),+r, found in cells cultured from lung metastasis. The...
Abstract Background Methylation of the O 6 -methylguanine-DNA methyltransferase ( MGMT ) gene promoter is a favorable prognostic factor in glioblastoma patients. However, reported methylation frequencies vary significantly partly due to lack consensus choice analytical method. Method We examined 35 low- and 99 high-grade gliomas using quantitative specific PCR (qMSP) pyrosequencing. Gene expression level was analyzed by RT-PCR. Results When qMSP, 26% low-grade 37% were found be methylated,...
The survival rates in population-based series of glioblastoma (GBM) differ substantially from those reported clinical trials. This discrepancy may be attributed to that patients recruited trials tend younger with better performance status. However, the proportion and characteristics a population considered either eligible or ineligible for is unknown. generalizability trial results therefore also uncertain.Using Cancer Registry Norway Brain Tumor Database at Oslo University Hospital, we...
Therapy of recurrent glioblastoma (GBM) is challenging due to lack standard treatment. We investigated physicians’ treatment choice at recurrence and prognostic predictive factors for survival in GBM patients from Norway’s two largest regional hospitals. Clinicopathological data n = 467 treated Haukeland Oslo university hospitals January 2015 December 2017 was collected. Data included tumour location, promoter methylation O 6 methylguanine-DNA methyltransferase ( MGMT ) mutation isocitrate...
The empty sella turcica is defined as a which, regardless of its size, completely or partly filled with cerebrospinal fluid. An normal size frequent and probably finding in unselected autopsy series. In clinical series an usually appears enlarged often associated variety disorders, constituting the so-called syndrome. Several causes have been suggested: congenitally missing (deficient) sellar diaphragm without altered fluid dynamics, previous pituitary gland hypertrophy outcome tumor...
According to the American Society for Radiation Oncology's Model Policy published in 2014 (1), solid tumors children are considered among highest priority proton therapy. Worldwide, there currently 54 facilities offering therapy and 61 more under construction (2). As number of institutions proliferates, expert opinion is important guiding safe rational adoption use this technology young patients. In June 2015, 24 international leaders pediatric radiation oncology, medical physics,...
Traditional in vitro culturing of tumor cells has been shown to induce changes so that cultures no longer represent the origin. Serum-free conditions are used a variety cancers propagate stem-like vitro. Limited reports, however, exist on effects such propagation. We have compared from brain biopsies cultivated under serum-free at passages 2 and 10 describe culturing. were able establish cell lines 7 patients with glioblastoma. The adapted had 2.2 times increased population doubling rate...
BackgroundWe have previously characterized 19 ependymal tumors using Giemsa banding and high-resolution comparative genomic hybridization. The aim of this study was to analyze these searching for fusion genes.
RNA-sequencing was performed on three tenosynovial giant cell tumors (TSGCT) in an attempt to elicit more information the mechanisms of CSF1 expression this tumor type. A novel CSF1-S100A10 fusion gene found a TSGCT that carried translocation t(1;1)(q21;p11) as sole karyotypic abnormality. In gene, part coding for protein (exons 1-8 sequences with accession nos. NM_000757 and NM_172212) is fused 3'-part S100A10. Since stop codon TAG present it, gene's predominant consequence seems be...
Background: Although methylation of the O<sup>6</sup>-methylguanine-DNA methyltransferase (MGMT) gene promoter predicts response to temozolomide in patients with glioblastoma, no consensus exists as which assay is best for its detection. Materials and Methods: Methylation MGMT was examined by methylation-specific polymerase chain reaction (MSP), quantitative real-time MSP, methylation-sensitive high-resolution melting analysis, two commercial pyrosequencing (PSQ) kits. Survival compared...
Purpose To retrospectively investigate the uptake of 18 F-fluciclovine on PET/CT in patients with suspected recurrent high-grade glioma (HGG). Methods Twenty-one were included. The standard truth was histopathologic interpretation if available. When histopathology not available or rebiopsy did show signs malignancy, clinical follow-up including MRI and outcome considered truth. Results All 21 met reference either proof HGG recurrence (n = 10) disease progression clinically tumor growth...
Abstract A novel methylation class, “neuroepithelial tumor, with PLAGL1 fusion” (NET-PLAGL1), has recently been described, based on epigenetic features, as a supratentorial pediatric brain tumor recurrent histopathological features suggesting an ependymal differentiation . Because of the recent identification this neoplastic entity, few histopathological, radiological and clinical data are available. Herein, we present detailed series nine cases -fused tumors, reclassified from ependymomas,...
Diffuse gliomas are malignant brain tumors that grow widespread through the brain.The complex interactions between neoplastic cells and normal tissue, as well treatment-induced changes often encountered, make glioma tumor growth modeling challenging.In this paper, we present a novel end-to-end network capable of future predictions masks multi-parametric magnetic resonance images (MRI) how will look at any time points for different treatment plans.Our approach is based on cutting-edge...
Background Radiation-induced changes following proton beam therapy in isocitrate dehydrogenase ( IDH )-mutated diffuse central nervous system (CNS) World Health Organization (WHO) grade 2 and 3 gliomas are not well characterized. We present a patient with an -mutant astrocytoma CNS WHO treated postradiation MRI suggestive of neoplastic progression that surprisingly turned out to be reactive. Case presentation A man his twenties underwent surgery near gross total resection for what 3. He was...
Abstract Cytogenetics is of considerable value when diagnosing lipomatous tumours, as different tumour types have more or less specific chromosomal abnormalities. One such entity lipoblastoma, which a benign that often exhibits rearrangements chromosome bands 8q11–13, and the gene PLAG1 has been implicated target these changes. All tumours karyotyped at Norwegian Radium Hospital were reviewed, looking for 8q11–13. Five exhibiting abnormalities affecting this region found. Only one them was...
The discovery of stem cells in the adult human brain has revealed new possible scenarios for treatment sick or injured brain. Both clinical use and preclinical research on neural have, however, been seriously hampered by fact that it impossible to passage these more than a very few times with little expansion cell numbers. Having explored number alternative culturing conditions we here present an efficient method establishment propagation from whatever tissue samples have tried. We describe...
We previously reported that tumor 3D volume growth rate (3DVGR) classification could help in the assessment of drug activity patients with meningioma using 3 main classes and a total 5 subclasses: class 1: decrease; 2: stabilization or severe slowdown; 3: progression. The EORTC-BTG-1320 clinical trial was randomized phase II evaluating efficacy trabectedin for recurrent WHO 2 meningioma. Our objective to evaluate discriminative value 3DVGR EORTC-BTG-1320.
The methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter region is essential in evaluating prognosis and predicting drug response patients with glioblastoma. In this study, we evaluated utility using nanopore long-read sequencing as a method for assessing levels throughout MGMT CpG-island, compared its performance to established techniques demonstrated clinical applicability.