A5042368914- Lymphoma Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Cutaneous Melanoma Detection and Management
- Cancer and Skin Lesions
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Angiogenesis and VEGF in Cancer
- Cutaneous lymphoproliferative disorders research
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Viral-associated cancers and disorders
- HER2/EGFR in Cancer Research
- Ovarian cancer diagnosis and treatment
- Immunotherapy and Immune Responses
- Immunodeficiency and Autoimmune Disorders
- Hedgehog Signaling Pathway Studies
- Chronic Lymphocytic Leukemia Research
- Glycosylation and Glycoproteins Research
- T-cell and Retrovirus Studies
- Chromatin Remodeling and Cancer
- Pleural and Pulmonary Diseases
- Genomic variations and chromosomal abnormalities
- Vascular Tumors and Angiosarcomas
- AI in cancer detection
- Polyomavirus and related diseases
Oslo University Hospital
2002-2024
Ullevål Sykehusapotek
2022
University of Oslo
2002-2015
Akershus University Hospital
2014-2015
Medical University of Sofia
2002-2005
Norwegian Cancer Society
2004-2005
Folliculotropic mycosis fungoides is a variant of cutaneous T-cell lymphoma with distinct clinicopathological features. We describe here the clinical presentation, pathology findings and treatment outcome in 15 Norwegian patients. All patients were diagnosed between 1997 2010 at Oslo University Hospital. A spectrum skin lesions, both typical atypical, such as leonine facies, acneiform psoriasiform plaques, purulent ulcerations cystic milia-like lesions for fungoides, seen. Histological...
The differential diagnosis between bone marrow involvement by lymphoplasmacytic lymphoma (LPL) and marginal zone (MZL) is challenging because histology immunophenotype of both diseases overlap. We revisited the diagnostic pathology features in marrow. studied a series trephine biopsy specimens from 59 patients with Waldenström macroglobulinemia without extramedullary 23 well-characterized MZL who also had involvement. H&E- immunoperoxidase-stained sections as well flow cytometry classic...
The presence of effusion in a patient with history primary malignant tumor elsewhere the body is generally accepted as clinical manifestation metastatic disease. Even those cases, it sometimes difficult to differentiate reactive mesothelial cells from carcinoma cells. Another challenging issue especially field serous effusions differential diagnosis between mesothelioma and adenocarcinoma. aim this study was evaluate potential use D2-40 antibody detecting M2A oncofetal antigen effusions. Two...
Dhakal H P, Naume B, Synnestvedt M, Borgen E, Kaaresen R, Schlichting Wiedswang G, Bassarova A, Holm Giercksky K‐E & Nesland J M (2012) Histopathology 61, 350–364 Expression of vascular endothelial growth factor and receptors 1 2 in invasive breast carcinoma: prognostic significance relationship with markers for aggressiveness Aims: Vascular (VEGF), VEGF receptor (VEGFR‐1) (VEGFR‐2) play a role cancer angiogenesis. We examined the expression clinical outcome other factors. Methods...
Abstract Purpose: The interaction between tumor cells, stroma, and endothelial cells is important for the dissemination of cells. aim present study to examine vascularity in primary breast carcinomas its prognostic significance relationship with cell dissemination. Experimental Design: A total 498 invasive were analyzed. Representative sections stained CD34 CD105, was quantified by Chalkley method. counts, vascular invasion, disseminated (DTC) bone marrow, other clinicopathologic variables,...
Background/Aim: Malignant chondroid syringoma is a rare tumor of unknown pathogenesis. Materials and Methods: Genetic analyses were performed on malignant syringoma. Results: G-banding analysis short-term cultured cells yielded the karyotype 46,Y,t(X;6)(p11;p21)[15]/46,XY[2]. RNA sequencing detected an in-frame fusion PHF1 from 6p21 with TFE3 Xp11, verified by RT-PCR Sanger sequencing. Genomic PCR showed that PHF1-TFE3 junction was identical to found RT-PCR. Conclusion: genetically related...
Pilomatrix carcinoma is a rare skin tumor with an origin from hair matrix cells. The locally aggressive great tendency for recurrence, but the metastatic potential limited. A pilomatrix in 76‐year‐old female lymph node metastases presented. In addition to classical histopathological criteria and DNA ploidy analysis, broad panel of antibodies was used evaluation potential. Both primary metastasis revealed extremely high proliferation apoptotic rates. High constant expressions CD44v6...
Manual counting of microvessels as intratumoral microvessel density (MVD) and Chalkley have been used in several studies to assess the prognostic impact vascularity invasive breast carcinomas. In our present study, aim was evaluate value angiogenesis carcinoma assessed by MVD techniques same series patients. A total 498 patients with median follow up time 85 months were evaluated. The tumour quantified both manual count CD34 stained slides a single investigator blinded clinical information....
Transdifferentiation of B cell lymphoma germinal center origin to histiocytic sarcoma has recently been described but is a rare occurrence. The cause for loss differentiation in these lymphomas unknown. We investigated whether somatic hypermutation the PAX-5 gene, transcription factor that important maintaining identity and frequently mutated origin, might be expression thus phenotype. However, no gene was detected two cases we studied. molecular basis transdifferentiation remains therefore...
Representative tumour sections from 468 patients with invasive breast cancer were immunostained for cyclooxygenase-2 (COX-2) and evaluated. The relationships between COX-2 expression, clinical outcome various clinicopathological variables, including vascularity disseminated cells (DTC) in the bone marrow examined. expression carcinoma was positively associated oestrogen receptor and/or progesterone positivity (p<0.001). Triple-negative tumours showed no/low more frequently than other types...
Acquired mutations were recently described in cutaneous T-cell lymphomas for the JAK1, JAK3, STAT3, and STAT5B genes of JAK-STAT pathway. In present study, RNA-sequencing a primary CD4 positive lymphoma carrying three-way t(9;13;16)(p24;q34;p11) chromosome translocation showed that JAK2 from band 9p24 was rearranged fused to novel partner gene, ATXN2L, 16p11. RT-PCR together with Sanger sequencing verified presence ATXN2L-JAK2 fusion transcript. The gene would code chimeric protein...
Most patients with mantle cell lymphoma present a diffuse or nodular infiltration of the involved organs at diagnosis. We two rare morphological variant, displaying partial involvement zone. Patient 1 presented an enlarged inguinal lymph node, which showed marked follicular hyperplasia singly spread Cyclin D1+ small lymphoid cells in zones. An additional node biopsy taken 3 months later same pattern. 2 classical bone marrow and gastro-intestinal involvement. However, revision appendectomy...
MX2 protein is a dynamin-like GTPase2 that has recently been identified as an interferon-induced restriction factor of HIV-1 and other primate lentiviruses. A single nucleotide polymorphism (SNP), rs45430, in intron the gene, was previously reported novel melanoma susceptibility locus genome-wide association studies. Functionally, however, it still unclear whether how contributes to tumorigenesis. Here, we show differentially expressed tumors cell lines, with most metastatic lines showing...
Evaluation of gene amplification and protein expression the c-erbB-2/neu in breast carcinomas has been an important task cancer management. Although immunohistochemistry is widely applied, fluorescence situ hybridization (FISH) technology shows its advantage discriminating tumors objective manner. More recently, development LightCycler permits evaluation with a small volume DNA run 20 microL glass capillary. In this study, series 87 were chosen for detected by both FISH. Real-time polymerase...
Family history of breast carcinoma, multicentric tumor foci in one breast, and situ lobular carcinoma increase the risk bilateral cancer (BBC), synchronous or metachronous. Synchronous tumors are designated as simultaneous if they appear at same time. The CD44 family cadherin/catenin immunophenotype this group BBCs has not yet been evaluated. aim study was to compare clinicopathological characteristics immunohistochemical profiles BBC corresponding lymph node metastases eight patients.In...
The aim of this study was to evaluate clinicopathological characteristics and immunophenotypes simultaneous bilateral adenocarcinomas the breast their axillary metastases. Immunohistochemical analysis in situ hybridization were performed using formalin-fixed/paraffin-embedded tissues. In total, 15 primary 9 metastatic tumors from 8 patients evaluated. expression estrogen receptor-alpha (ER-alpha), progesterone receptor (PR), Ki 67, p53, bcl-2, bax evaluated by immunohistochemistry. Her2 gene...
Histopathological assessment of melanoma and other melanocytic skin lesions can be difficult vary between pathologists.Histopathological slides 196 from 2009 2018-2019 were obtained the archive Department Pathology at Oslo University Hospital classified into six diagnostic categories: 1) benign nevus, 2) irregular/dysplastic i.e. dysplastic nevus with moderate atypia, 3) severe 4) in situ, 5) superficial spreading or lentiginous 6) nodular melanoma. The then examined independently blindly by...
Abstract Generalised pustular psoriasis (GPP) is characterised by a widespread rash with pustules and fever. Clinical the histological overlap delayed hypersensitivity reaction acute generalised exanthematous pustulosis may delay diagnostics initiation of correct treatment. In this case‐report, we describe an Human immunodeficiency virus positive patient GPP possible triggered monkeypox vaccination eventually successfully treated spesolimab, interleukin‐36 inhibitor.