Juliette A. Randerson‐Moor
A5057826438- Cutaneous Melanoma Detection and Management
- Vitamin D Research Studies
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Melanoma and MAPK Pathways
- Cancer Immunotherapy and Biomarkers
- Skin Protection and Aging
- melanin and skin pigmentation
- Lymphoma Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- Mast cells and histamine
- Molecular Biology Techniques and Applications
- Bone and Dental Protein Studies
- Genetic factors in colorectal cancer
- CAR-T cell therapy research
- CRISPR and Genetic Engineering
- Ovarian cancer diagnosis and treatment
- Cancer-related Molecular Pathways
- Cancer, Stress, Anesthesia, and Immune Response
- Biotin and Related Studies
- Psoriasis: Treatment and Pathogenesis
- Genetic Associations and Epidemiology
- DNA Repair Mechanisms
- Thyroid Cancer Diagnosis and Treatment
- bioluminescence and chemiluminescence research
University of Leeds
2013-2024
St James's University Hospital
2009-2023
Institute of Molecular Medicine
2023
Cancer Research And Biostatistics
2023
Sheba Medical Center
2017
Wellcome Trust
2016
Cancer Research UK
2004-2011
Royal Surrey County Hospital
2009-2010
St George's Hospital
2009-2010
Queen Alexandra Hospital
2010
A cohort study was carried out to test the hypothesis that higher vitamin D levels reduce risk of relapse from melanoma.A pilot retrospective 271 patients with melanoma suggested may protect against recurrence melanoma. We tested these findings in a survival analysis 872 recruited Leeds Melanoma Cohort (median follow-up, 4.7 years).In study, self-reports taking supplements were nonsignificantly correlated reduced (odds ratio = 0.6; 95% CI, 0.4 1.1; P .09). Nonrelapsers had mean...
The melanoma–astrocytoma syndrome is characterized by a dual predisposition to melanoma and neural system tumours, commonly astrocytoma. Germline deletions of the region on 9p21 containing CDKN2A CDKN2B genes exon 1β have been reported in kindreds, implicating contiguous tumour suppressor gene deletion as cause this syndrome. We describe family multiple cell tumours segregating with germline p14ARF-specific gene. This does not affect coding or minimal promoter sequences either genes. Our...
Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously mean leukocyte telomere were either genotyped or well-imputed in 11108 case patients and 13933 control from Europe, Israel, the United States Australia, four seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts length, derived these SNPs, is strongly (P = 8.92x10-9, two-sided) melanoma risk. This demonstrates...
1α,25-Dihydroxyvitamin D3 signals via the vitamin D receptor (VDR). Higher serum is associated with thinner primary melanoma and better outcome, although a causal mechanism has not been established. As patients commonly avoid sun exposure, consequent deficiency might worsen outcomes, we interrogated 703 transcriptomes to understand role of D-VDR signaling replicated findings in The Cancer Genome Atlas metastases.
Immunotherapy prolongs survival in only a subset of melanoma patients, highlighting the need to better understand driver tumor microenvironment. We conducted bioinformatic analyses 703 transcriptomes probe immune landscape primary cutaneous melanomas population-ascertained cohort. identified and validated 6 immunologically distinct subgroups, with largest having lowest scores poorest survival. This poor-prognosis subgroup exhibited expression profiles consistent β-catenin–mediated failure...
Carrying the cyclin-dependent kinase inhibitor 2A (CDKN2A) germline mutations is associated with a high risk for melanoma. Penetrance of CDKN2A modified by pigmentation characteristics, nevus phenotypes, and some variants melanocortin-1 receptor gene (MC1R), which known to have role in process. However, investigation associations both MC1R host phenotypes melanoma has been limited.We included 815 mutation carriers (473 affected, 342 unaffected, melanoma) from 186 families 15 centers Europe,...
The tumor suppressors p14(ARF) (ARF) and p16(INK4A) (p16) are encoded by overlapping reading frames at the CDKN2A/INK4A locus on chromosome 9p21. In human melanoma, accumulated evidence has suggested that predominant suppressor 9p21 is p16, not ARF. However, recent observations from melanoma-prone families murine melanoma models suggest a p16-independent role for We analyzed group of metastases cell lines to investigate directly whether somatic alterations ARF gene support its as in assuming...
Gene expression studies in melanoma have been few because tumors are small and cryopreservation is rarely possible. The purpose of this study was to evaluate the Illumina DASL Array Human Cancer Panel for gene formalin-fixed primary identify prognostic biomarkers.Primary from two were sampled using a tissue microarray needle. Study 1: 254 cohort recruited 2000 2006. 2: 218 case-control patients undergoing sentinel node biopsy.RNA obtained 76% blocks; 1.4% samples failed analysis (transcripts...
Lower 25‐hydroxyvitamin D 2 /D 3 levels at melanoma diagnosis are associated with thicker primaries and poorer survival. We postulated that this might relate to the deleterious effect of systemic inflammation as inversely C‐reactive protein. 2,182 participants in Leeds Melanoma Cohort (median follow‐up 7.98 years) provided data on drug exposure, comorbidities a serum level recruitment. Factors reported modify (low vitamin levels, high body mass index, use aspirin or nonsteroidal...
It is unclear to what degree genomic and traditional (phenotypic environmental) risk factors overlap in their prediction of melanoma risk. We evaluated the incremental contribution common variants (in pigmentation, nevus, other pathways) with factors, using data from two population-based case-control studies Australia (n = 1,035) United Kingdom 1,460) that used same questionnaires. Polygenic scores were derived 21 gene regions associated odds ratios published meta-analyses. Logistic...
Inherited MC1R variants modulate MITF transcription factor signaling, which in turn affects tumor cell proliferation, apoptosis, and DNA repair. The aim of this BioGenoMEL collaborative study 10 melanoma cohorts was to test the hypothesis that inherited thereby moderate survival expectation. A analysis largest cohort (Leeds) carried out adjusting for factors known impact on survival. results were then compared with data from nine smaller cohorts. absence any consensus alleles associated a...
Mutations in the CDKN2A and CDK4 genes predispose to melanoma. From three case-control studies of cutaneous melanoma, we estimated prevalence predictors these mutations for people from regions with widely differing latitudes melanoma incidence. Population-based cases controls United Kingdom (1586 cases, 499 controls) Australia (596 early-onset 476 controls), a hospital-based series Spain (747 109 were screened variants all exons p16INK4A binding domain CDK4. The was similar across regions:...
Abstract The immune response to melanoma improves the survival in untreated patients and predicts checkpoint blockade. Here, we report genetic environmental predictors of a large primary cutaneous cohort. Bioinformatic analysis 703 tumor transcriptomes was used infer cell infiltration categorize tumors into subgroups, which were then investigated for association with biological pathways, clinicopathologic factors, copy number alterations. Three “low”, “intermediate”, “high” signals,...
Abstract Purpose: To use gene expression profiling of formalin-fixed primary melanoma samples to detect patterns that are predictive relapse and response chemotherapy. Experimental Design: Gene profiles were identified in from two studies (472 tumors). data for 502 cancer-related genes these combined analysis. Results: Increased DNA repair most strongly predicted was associated with thicker tumors. RAD51 the relapse-free survival unadjusted analysis (hazard ratio, 2.98; P = 8.80 × 10−6)....