A5009854212- Glioma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Radiation Therapy and Dosimetry
- Oral and Maxillofacial Pathology
- Meningioma and schwannoma management
- Advanced Radiotherapy Techniques
- Pituitary Gland Disorders and Treatments
- Brain Metastases and Treatment
- Neuroblastoma Research and Treatments
- Surgical site infection prevention
- Ocular Oncology and Treatments
- Management of metastatic bone disease
- Head and Neck Surgical Oncology
- Testicular diseases and treatments
- Childhood Cancer Survivors' Quality of Life
- Radiation Detection and Scintillator Technologies
- Ear and Head Tumors
- Head and Neck Cancer Studies
- Neurofibromatosis and Schwannoma Cases
- Pleural and Pulmonary Diseases
- Advanced Neural Network Applications
- Vascular Malformations Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- Anesthesia and Neurotoxicity Research
University of Kansas Medical Center
2020-2024
University of Kansas
2020-2023
Florida College
2016-2020
University of Florida
2013-2020
University of Florida Health
2012-2019
Jacksonville University
2019
Jacksonville College
2019
Mayo Clinic in Florida
2019
WinnMed
2019
Radiation Oncology Associates
2016
Proton therapy offers superior low and intermediate radiation dose distribution compared with photon-based for brain skull base tumors; yet tissue within adjacent to the target volume may receive a comparable dose. We investigated tolerance of pediatric brainstem proton identified prognostic variables.All patients < 18 years old tumors or treated from 2007 2013 were reviewed; 313 who received > 50.4 CGE included in this study. Brainstem toxicity was graded according NCI Common Terminology...
Spinal chordomas can have high local recurrence rates after surgery with or without conventional dose radiation therapy (RT). Treatment outcomes and prognostic factors high-dose proton-based RT were assessed.The authors conducted a retrospective review of 126 treated patients (127 lesions) categorized according to disease status (primary vs recurrent), resection (en bloc intralesional), margin status, timing.Seventy-one sacrococcygeal, 40 lumbar, 16 thoracic analyzed. Mean was 72.4 GyRBE...
Dosimetric studies show that proton therapy can reduce the low/intermediate radiation dose to uninvolved tissue in children with low-grade glioma (LGG). For this reason, LGG is fourth most common pediatric tumor treated therapy, yet clinical outcome data on efficacy and toxicity are limited.We reviewed medical records of 174 (≤21 years old) nonmetastatic enrolled a prospective protocol between 2007 2017. We assessed outcomes analyzed patient, tumor, treatment-related variables.The median age...
Proton therapy can reduce the low and intermediate radiation dose to uninvolved brain tissue in children with intracranial ependymomas, which may improve functional outcomes second malignancies survivors. Accordingly, ependymoma has become most common pediatric tumor treated proton therapy, yet data on efficacy toxicity are limited.Between June 2007 February 2017, 179 (≤21 years old) nonmetastatic grade II/III received at our institution. Median age, 3.5 (range, 0.7-21); 58% were male. Most...
Background. The purpose of this study is to review late toxicity following craniospinal radiation for early-stage medulloblastoma.Material and methods. Between 1963 2008, 53 children with stage M0 (n = 50) or M1 3) medulloblastoma were treated at our institution. median age diagnosis was 7.1 years (range 1.2–18.5). irradiation (CSI) dose 28.8 Gy 21.8–38.4). total dose, including boost, 54 42.4–64.8 Gy). Since 1963, the CSI has been incrementally lowered high-risk boost volume reduced....
Compared to CONV-RT (with conventional dose rate), FLASH-RT ultra-high rate) can provide biological sparing for organs-at-risk (OARs) via the so-called FLASH effect, in addition physical sparing. However, effect only occurs, when both and rate meet certain minimum thresholds. This work will develop a simultaneous optimization (SDDRO) method accounting constraints during treatment planning pencil-beam-scanning proton therapy.
In treatment planning, beam angle optimization (BAO) refers to the selection of a subset with given number angles from all available that provides best plan quality. BAO is NP-hard combinatorial problem. Although exhaustive search (ES) can exactly solve by exploring possible combinations, ES very time-consuming and practically infeasible.
A constant relative biological effectiveness of 1.1 in current clinical practice proton radiotherapy (RT) is a crude approximation and may severely underestimate the dose from RT to normal tissues, especially near treatment target at end Bragg peaks that exhibits high linear energy transfer (LET). LET optimization can account for protons during planning, minimizing hot spots tissues. However, usually nonlinear nonconvex solve, which this work will develop an effective method based on...
We have used human brain-derived endothelial cells (HBECs) maintained under basal culture conditions in a Boyden chamber assay system as an vitro model of migration systemic immune origin across the blood brain barrier (BBB) during initiation CNS-directed inflammatory response. In this study we evaluated molecular mechanisms that regulate passage ex vivo peripheral blood-derived monocytes and effects such on properties both HBECs monocytes. Our results indicate can migrate absence...
Out-of-field neutron dissemination during double-scattered proton therapy has raised concerns of increased second malignancies, disproportionally affecting pediatric patients due to the proportion body exposed scatter dose and inherent radiosensitivity developing tissue. We sought provide empiric data on incidence early tumors.Between 2006 2019, 1713 consecutive children underwent therapy. Median age at treatment was 9.1 years; 371 were ≤3 years old. Thirty-seven (2.2%) had tumor...
This single-institution report describes long-term disease control and late effects in pediatric patients with low-grade glioma (LGG) following radiotherapy (RT).Twenty-nine LGG were treated photon-based RT from 1970 to 2004 (mean age at time of RT, 9.8 y; range, 0.6 19 y). One patient underwent gross total resection, 25 subtotal resection or biopsy, 3 based on radiographic characteristics alone. Three chemotherapy before RT. The median dose was 54 Gy (range, 40 55 Gy).The follow-up 17.8...
Abstract Background International, multidisciplinary care of children with central nervous system (CNS) tumors presents unique challenges. The aim this study is to report patient outcomes U.K. referred for proton therapy a North American facility. Methods From 2008 2016, 166 approved CNS were treated at single academic medical center in the United States. Median age was 7 years (range, 1–19). follow‐up 2.6 years. Results 3‐year actuarial overall survival (OS) and local control (LC) rates 96%...
Abstract Purpose Despite the dosimetric advantages of proton therapy, little data exist on patients who receive therapy for Ewing sarcoma cranium and skull base. This study reports local disease control toxicity in such patients. Materials/methods We reviewed 25 (≤21 years old) with nonmetastatic base treated between 2008 2018. Treatment was graded per Common Terminology Criteria Adverse Events v4.0. The Kaplan‐Meier product limit method provided estimates survival. Results Median patient...
Abstract Purpose In children treated for nasopharyngeal carcinoma, proton therapy and postchemotherapy target volumes can reduce the radiation dose to developing tissue in brain skull base region. We analyzed outcomes with carcinoma induction chemotherapy followed by moderate‐dose therapy. Methods/Materials Seventeen patients nonmetastatic nonkeratinizing undifferentiated/poorly differentiated underwent double‐scattered between 2011 2017. Median age was 15.3 years (range, 7‐21). The American...