A5103192188- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Management of metastatic bone disease
- Oral and Maxillofacial Pathology
- Spine and Intervertebral Disc Pathology
- Infectious Diseases and Tuberculosis
- Spinal Fractures and Fixation Techniques
- Musculoskeletal synovial abnormalities and treatments
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Protein Degradation and Inhibitors
- Cancer Immunotherapy and Biomarkers
- Pelvic and Acetabular Injuries
- Amoebic Infections and Treatments
- Spinal Dysraphism and Malformations
- Cancer Diagnosis and Treatment
- Bone health and treatments
- Cancer-related Molecular Pathways
- Total Knee Arthroplasty Outcomes
- Medical Imaging and Analysis
- Tumors and Oncological Cases
- Bone and Joint Diseases
- Shoulder and Clavicle Injuries
Harvard University
2015-2025
Massachusetts General Hospital
2016-2025
Cedars-Sinai Medical Center
2024-2025
Universitätsmedizin Göttingen
2025
Boston University
2022
Brigham and Women's Hospital
2007-2018
Clinical Orthopaedics and Related Research
2018
Zimmer Biomet (United States)
2018
Stryker (United States)
2018
Committee on Publication Ethics
2018
Background Negative surgical margins are uncommon for spine sarcomas; hence, adjuvant radiotherapy (RT) may be recommended but tumor dose constrained by spinal cord, nerve, and viscera tolerance. Methods Prospective Phase II clinical trial incorporating high RT. Eligible patients had primary or locally recurrent thoracic, lumbar, and/or sacral spine/paraspinal chordomas sarcomas. Treatment included pre- post-operative photon/proton RT ± radical resection. Results Fifty (29 chordoma, 14...
Programmed cell death ligand 1 (PDL1, also known as B7H1) is a cell-surface protein that suppresses the cytotoxic CD8(+) T-cell-mediated immune response. PDL1 expression and its clinical relevance in sarcomas are not well understood. Therefore, we sought to measure RNA levels for 38 clinically annotated osteosarcoma tumor samples aimed determine if correlates with features tumor-infiltrating lymphocytes (TIL). Quantitative real-time RT-PCR was optimized 18 lines, of which 5 were derived....
This is a retrospective review of 49 cases giant cell tumor (GCT) the mobile spine treated surgically.Our goal was to determine which factors influenced local recurrence.GCT benign, locally aggressive that rarely occurs in spine. The management recurrence can be challenging.We performed analysis GCTs managed between 1970 and 2005. Median follow-up 145 months with minimum 2 years or until death. We used Kaplan-Meier method test whether Enneking stage, surgery type, surgical margin had...
Spinal chordomas can have high local recurrence rates after surgery with or without conventional dose radiation therapy (RT). Treatment outcomes and prognostic factors high-dose proton-based RT were assessed.The authors conducted a retrospective review of 126 treated patients (127 lesions) categorized according to disease status (primary vs recurrent), resection (en bloc intralesional), margin status, timing.Seventy-one sacrococcygeal, 40 lumbar, 16 thoracic analyzed. Mean was 72.4 GyRBE...
Background: Current prognostication models for survival estimation in patients with metastatic spine disease lack accuracy. Identifying new risk factors could improve existing models. We assessed associated surgically treated metastases, created a classic scoring algorithm, nomogram, and boosting tested the predictive accuracy of three algorithms at estimating survival. Methods: included 649 from two tertiary care referral centers this retrospective study (2002 to 2014). A multivariate Cox...
A retrospective review.The purpose of this study is to report the results high-dose proton based definitive radiotherapy for unresected spinal chordomas.Spine chordoma treated primarily by surgical resection. However, local recurrence rate high. Adjuvant improves control. In certain locations, such as high sacrum, resection may result in significant neurological dysfunction.We retrospectively reviewed 24 patients with newly diagnosed, previously untreated chordomas (core biopsy only; no...
The molecular events in chordoma pathogenesis have not been fully delineated, particularly with respect to copy number changes. Understanding alterations may reveal critical disease mechanisms that could be exploited for tumor classification and therapy. We report the analysis of 21 sporadic chordomas using array comparative genomic hybridization (CGH). Recurrent changes were further evaluated immunohistochemistry, methylation specific PCR, quantitative real-time PCR. Similar previous...
Myxoid liposarcoma (MLS) has an unusual tendency for extrapulmonary metastasis, particularly to the spine and soft tissues. The objective of this study was determine prevalence spinal treatment outcomes, optimal screening method metastasis in patients with MLS.Data from had metastases were obtained authors' institutional tissue sarcoma database. accuracy which positron emission tomography (PET) scans bone identified metastatic lesions compared magnetic resonance imaging (MRI). Clinical...
Insulin-like growth factor-I receptor (IGF-IR) is an important mediator of tumor cell survival and shows prognostic significance in sarcoma. To explore potential therapeutic strategies for interrupting signaling through this pathway, we assessed the ability cyclolignan picropodophyllin (PPP), a member family, to selectively inhibit tyrosine kinase activity IGF-IR several sarcoma line model systems. Of diverse subtypes studied, osteosarcoma lines were found be particularly sensitive...
Retrospective case series.To determine the effect of modern surgical and aggressive radiation techniques on outcome in patients with spinal chondrosarcoma.Chondrosarcoma spine presents a difficult challenge. Surgical excision is considered standard care, yet complete not always feasible, rates local control survival are inferior to those reported for extremities.We performed retrospective review cases chondrosarcoma involving above sacrum treated surgically at our institution between 1984...
En bloc resection for treatment of sacral tumors is the approach choice patients with resectable who are well enough to undergo surgery, and studies describe patient survival, postoperative complications, recurrence rates associated this treatment. However, most these do not provide patient-reported functional outcomes other than binary metrics bowel bladder function postresection.The purpose study was use validated tools compare quality life based on level in terms (1) physical mental...
Background: Total en bloc spondylectomy (TES) for the treatment of spinal tumors decreases local recurrence and improves survival compared with intralesional resection. TES approaches vary in both number stages to complete procedure instruments which osteotomies are performed. Methods: We describe a 2-stage technique that employs use threadwire saws. performed retrospective review cases primary solitary metastases involving thoracic or lumbar spine treated our modified at institution between...