A5027890198- Traumatic Brain Injury and Neurovascular Disturbances
- Surgical Simulation and Training
- Vascular Malformations Diagnosis and Treatment
- Trigeminal Neuralgia and Treatments
- Glioma Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Neuroblastoma Research and Treatments
- Artificial Intelligence in Healthcare and Education
- Cerebrospinal fluid and hydrocephalus
- Neurogenetic and Muscular Disorders Research
- Anatomy and Medical Technology
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Health Literacy and Information Accessibility
- Meningioma and schwannoma management
- Safety Warnings and Signage
- Neurogenesis and neuroplasticity mechanisms
- Migraine and Headache Studies
- Chromatin Remodeling and Cancer
- Microtubule and mitosis dynamics
- Dental Anxiety and Anesthesia Techniques
- Scoliosis diagnosis and treatment
- Spine and Intervertebral Disc Pathology
University of Ottawa
2018-2025
Imperial College London
2023-2025
Ottawa Hospital
2021-2024
University of British Columbia
2024
Health Sciences Centre
2024
University of Toronto
2024
Royal Columbian Hospital
2024
Dalhousie University
2024
Deleted Institution
2022-2023
Ottawa Hospital Research Institute
2021-2023
The mammalian spinal cord functions as a community of cell types for sensory processing, autonomic control, and movement. While animal models have advanced our understanding cellular diversity, characterizing human biology directly is important to uncover specialized features basic function pathology. Here, we present taxonomy the adult using single-nucleus RNA sequencing with spatial transcriptomics antibody validation. We identified 29 glial clusters 35 neuronal clusters, organized...
Importance There is a paucity of data comparing patient-reported outcomes across surgeon age. Prior work has focused on adverse event rates for age variety surgical procedures. Objective To compare outcomes, expectation fulfillment, and satisfaction measures after spine surgery categories. Design, Setting, Participants This retrospective cohort study was conducted at multicentered tertiary referral centers Canada. Patients with degenerative conditions the were enrolled in national research...
Abstract The mammalian spinal cord functions as a community of glial and neuronal cell types to accomplish sensory processing, autonomic control, movement; conversely, the dysfunction these following injury or disease states can lead chronic pain, paralysis, death. While we have made great strides in understanding cellular diversity animal models, it is crucial characterize human biology directly uncover specialized features basic function illuminate pathology. Here, present taxonomy adult...
We describe a minimally invasive endovascular approach to treat an arteriovenous fistula of the scalp. performed direct puncture lesion through patient's scalp for liquid embolic agent injection along with external compression superficial temporal artery perform "manual pressure-cooker technique." The combination these techniques resulted in excellent clinical and radiographic outcome.
Anaphase onset is an irreversible cell cycle transition that triggered by the activation of protease Separase. Separase cleaves Mcd1 (also known as Scc1) subunit Cohesin, a complex proteins physically links sister chromatids, triggering chromatid separation. regulated degradation anaphase inhibitor Securin which liberates from inhibitory Securin/Separase complexes. In many organisms, not essential suggesting additional mechanisms. this work, we show in budding yeast Cdk1 activates (Esp1...
Traumatic spinal cord injury (SCI) leads to profound neurologic sequelae, and the provision of life-supporting treatment serves great importance among this patient population. The decision for withdrawal (WLST) in complete traumatic SCI is complex with lack guidelines limited understanding practice patterns. We aimed evaluate individual contextual factors associated WLST assess between-center differences patterns across North American trauma centers patients cervical SCI.This retrospective...
Children diagnosed with medulloblastoma (MB) who are refractory to upfront therapy or experience recurrence have very poor prognoses. Although phase I and II trials exist, these treatments bear significant treatment-related morbidity mortality.A retrospective review of children a MB from 2002 2015 at McMaster University was undertaken.Recurrent disease in 10 patients involved leptomeningeal dissemination, 3 experiencing local recurrence. In three recurrent the significantly progressed, were...
Background Distracted driving is a global epidemic, injuring and killing thousands of people every year. To better understand why still engage in this dangerous behavior, we need to assess how the public gets informed about issue. Knowing that many use internet as their primary source initial research on topics interest, conducted an assessment popular distracted videos found YouTube. Objective This study aimed gauge popularity messages portrayed by classifying content, context, quality...
The scanning fiber endoscope (SFE) is a novel medical imaging device that has been used in various vascular beds as form of angioscopy, well tracts and duct systems for endoluminal imaging. Owing to its miniaturized form, high resolution, flexibility, it demonstrated success across wide range diagnostic applications.To demonstrate, by performing third ventriculostomy visualizing the cranial nerves brainstem anatomy, that, without modification, SFE can be through transcranial approach...
Intracerebral abscess is a life-threatening condition for which there are no current, widely accepted neurosurgical management guidelines. The purpose of this study was to investigate Canadian practice patterns the medical and surgical primary, recurrent, multiple intracerebral abscesses.A self-administered, cross-sectional, electronic survey distributed active staff resident members Neurosurgical Society Neurosurgery Research Collaborative. Responses between subgroups were analyzed using...
Evaluating patients with a traumatic spinal cord injury can be complicated by other injuries. In this case, 24-year-old woman injured needlefish presented combined motor and sensory defects, cranial nerve deficits, blunt vascular injury. This case highlights the importance of neurologic localizations an understanding injuries involving various ascending descending tracts. Appreciation these anatomical considerations through illustrates diagnostic approach to evaluation. While we present...
Objective: Multiple strategies exist to facilitate microdissection and obliteration of intracranial aneurysms during microsurgical clipping. Rapid ventricular pacing (RVP) can be used induce controlled transient hypotension aneurysm manipulation. We report the indications outcomes intraoperative RVP for clipping ruptured unruptured complex aneurysms. Methods: completed a retrospective review adult patients who underwent RVP-facilitated elective emergent by single senior neurosurgeon between...
<title>Abstract</title> Direct comparison of proliferation characteristics between primary adult human neural stem/progenitor cells (NSPCs) and their animal counterparts has been challenging due to the difficulty in obtaining viable spinal cord tissue. Here, we present first assessment rates NSPCs derived from samples development a multivariate linear regression model predict dynamics. We cultured 42 tissue samples, sourced 27 organ donors, examine doubling times rates. Key characteristics,...
Rotational angiography, often referred to as a "spin", is typically presented in 2D. Since rotational angiograms are composed of images acquired from multiple angles, we took advantage this property develop method for converting any angiogram into 3D video. Our aim was low-cost and easily distributable solution without requiring additional hardware or altering acquisition techniques. Six previously our institution were imported using custom-written code exported anaglyph (red-cyan) videos....
<sec> <title>BACKGROUND</title> Distracted driving is a global epidemic, injuring and killing thousands of people every year. To better understand why still engage in this dangerous behavior, we need to assess how the public gets informed about issue. Knowing that many use internet as their primary source initial research on topics interest, conducted an assessment popular distracted videos found YouTube. </sec> <title>OBJECTIVE</title> This study aimed gauge popularity messages portrayed by...