A5005103459- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Spinal Cord Injury Research
- Neurogenetic and Muscular Disorders Research
- Mobile Health and mHealth Applications
- Sleep and related disorders
- Amyotrophic Lateral Sclerosis Research
- Healthcare Systems and Technology
- Robotic Locomotion and Control
- Impact of Light on Environment and Health
- Circadian rhythm and melatonin
- Zebrafish Biomedical Research Applications
- Healthcare Policy and Management
University of Colorado Denver
2024
National Institute of Neurological Disorders and Stroke
2021-2023
National Institutes of Health
2021-2022
University of Washington
2022
The mammalian spinal cord functions as a community of cell types for sensory processing, autonomic control, and movement. While animal models have advanced our understanding cellular diversity, characterizing human biology directly is important to uncover specialized features basic function pathology. Here, we present taxonomy the adult using single-nucleus RNA sequencing with spatial transcriptomics antibody validation. We identified 29 glial clusters 35 neuronal clusters, organized...
Abstract After spinal cord injury, tissue distal to the lesion contains undamaged cells that could support or augment recovery. Targeting these requires a clearer understanding of their injury responses and capacity for repair. Here, we use single nucleus RNA sequencing profile how each cell type in lumbar changes after thoracic mice. We present an atlas dynamic across dozens types acute, subacute, chronically injured cord. Using this resource, find rare neurons express signature...
In the absence of electric light, sleep for humans typically starts soon after dusk and at higher latitudes daily timing changes seasonally as photoperiod changes. However, access to light shields from natural changes, whether seasonal in occur despite this isolation light-dark cycle remains a matter controversy. We measured over 500 university students living city Seattle, WA (47.6°N) throughout four seasons; we show that even when are following school schedule, is delayed during fall...
Abstract The mammalian spinal cord functions as a community of glial and neuronal cell types to accomplish sensory processing, autonomic control, movement; conversely, the dysfunction these following injury or disease states can lead chronic pain, paralysis, death. While we have made great strides in understanding cellular diversity animal models, it is crucial characterize human biology directly uncover specialized features basic function illuminate pathology. Here, present taxonomy adult...
Abstract After spinal cord injury (SCI), the “spared” tissue below lesion contains undamaged cells that could support or augment recovery, but targeting these requires a clearer understanding of their responses and capacity for repair. Here, we used single nucleus sequencing to profile how each cell type in lumbar changes over time after thoracic injury. We present an atlas dynamic explore two unexpected findings. Amongst neurons, rare types expressed molecular signature regeneration amongst...
<sec> <title>UNSTRUCTURED</title> Using a crowdsource model, we developed web-based platform for medical school application tracking and data aggregation. </sec>