A5000334935- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- Particle physics theoretical and experimental studies
- Nuclear physics research studies
- Gene expression and cancer classification
- Scientific Computing and Data Management
- Particle Detector Development and Performance
- Research Data Management Practices
- Bioinformatics and Genomic Networks
- Nuclear Physics and Applications
- X-ray Spectroscopy and Fluorescence Analysis
- Astronomical and nuclear sciences
- Laser Applications in Dentistry and Medicine
- Gene Regulatory Network Analysis
- Occupational Health and Safety Research
- Nuclear reactor physics and engineering
- Photodynamic Therapy Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Statistical Methods and Bayesian Inference
- Health, Environment, Cognitive Aging
- Atomic and Molecular Physics
- Nanoplatforms for cancer theranostics
- Reliability and Agreement in Measurement
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
National Cancer Institute
2020-2024
Division of Cancer Epidemiology and Genetics
2020-2024
National Institutes of Health
2001-2023
Cancer Institute (WIA)
2023
National Cancer Institute
2023
Center for Information Technology
2004-2021
Universität Ulm
1998-2021
Institute for Laser Technology in Medicine and Measurement Technique
1997-2021
University of Maryland, College Park
1995-2004
Carnegie Mellon University
1999-2003
Abstract Single-cell RNA sequencing data can unveil the molecular diversity of cell types. Cell type atlases mouse spinal cord have been published in recent years but not integrated together. Here, we generate an atlas types based on single-cell transcriptomic data, unifying available datasets into a common reference framework. We report hierarchical structure postnatal relationships, with location providing highest level organization, then neurotransmitter status, family, and finally,...
Abstract After spinal cord injury, tissue distal to the lesion contains undamaged cells that could support or augment recovery. Targeting these requires a clearer understanding of their injury responses and capacity for repair. Here, we use single nucleus RNA sequencing profile how each cell type in lumbar changes after thoracic mice. We present an atlas dynamic across dozens types acute, subacute, chronically injured cord. Using this resource, find rare neurons express signature...
We analyzed 77 nonproductive and 574 productive human V(H)DJ(H) rearrangements with a newly developed program, JOINSOLVER. In the repertoire, H chain complementarity determining region 3 (CDR3(H)) was significantly shorter (46.7 +/- 0.5 nucleotides) than in repertoire (53.8 1.9 because of tendency to select less TdT activity D segments. Using criteria established by Monte Carlo simulations, segments could be identified 71.4% 64.4% rearrangements, mean 17.6 0.7 14.6 0.2 retained germline...
Abstract Data sharing is essential for reproducibility of epidemiologic research, replication findings, pooled analyses in consortia efforts, and maximizing study value to address multiple research questions. However, barriers related confidentiality, costs, incentives often limit the extent speed data sharing. Epidemiological practices that follow Findable, Accessible, Interoperable, Reusable (FAIR) principles can these by making resources findable with necessary metadata, accessible...
An excitation function of proton rapidity distributions for different centralities is reported from AGS Experiment E917 $\mathrm{Au}+\mathrm{Au}$ collisions at 6, 8, and 10.8 GeV/nucleon. The peripheral have a valley midrapidity which smoothly change to that display broad peak central collisions. mean loss increases with increasing beam energy, whereas the fraction protons consistent isotropic emission stationary source decreases energy. data suggest stopping substantially less than complete...
Collective transverse flow of nuclear matter was measured as a function the ratio neutrons to protons ( $N/Z$) interacting system for first time. The collisions three isotopically pure beams $A\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}58\mathrm{nuclei}$ with two $A\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}58\mathrm{targets}$ were studied at 55 MeV/nucleon. results variables demonstrate sensitivity transport models elementary aspects nucleon-nucleon collisions.
The energy at which collective transverse flow in the reaction plane disappears, balance ${E}_{\mathrm{bal}}$, is found to depend on isospin of system using reactions ${}^{58}\mathrm{Fe}{+}^{58}\mathrm{Fe}$ and ${}^{58}\mathrm{Ni}{+}^{58}\mathrm{Ni}$. more neutron-rich exhibits higher energies for all measured impact parameters, agreement with predictions a transport model incorporates an dependent mean field in-medium nucleon-nucleon cross sections.
<h3>Background</h3> Mapping job titles to standardised occupation classification (SOC) codes is an important step in identifying occupational risk factors epidemiological studies. Because manual coding time-consuming and has moderate reliability, we developed algorithm called SOCcer (Standardized Occupation Coding for Computer-assisted Epidemiologic Research) assign SOC-2010 based on free-text description components. <h3>Methods</h3> Job title task-based classifiers were by comparing...
Cluster analysis of gene-wide expression data from DNA microarray hybridization studies has proved to be a useful tool for identifying biologically relevant groupings genes and constructing gene regulatory networks. The motivation considering mutual information is its capacity measure general dependence among random variables. We propose novel clustering strategy based on minimizing clusters. Simulated annealing employed solve the optimization problem. Bootstrap techniques are get more...
E896 has measured Lambda production in 11.6A GeV/c Au-Au collisions over virtually the whole rapidity phase space. The midrapidity p(t) distributions have been for first time at this energy and appear to indicate that hyperons different freeze-out conditions than protons. A comparison with relativistic quantum molecular dynamics model shows while there is good shape agreement high predicts significantly slopes of m(t) spectra midrapidity. data, where overlap occurs, are consistent previously...
To examine the associations between sleep duration, continuity, timing, and mortality using actigraphy among adults. Data were from a cohort of 88 282 adults (40-69 years) in UK Biobank that wore wrist-worn triaxial accelerometer for 7 days. Actigraphy data processed to generate estimates duration other characteristics including wake after onset (WASO), number 5-minute awakenings, midpoint onset/wake-up least active 5 hours (L5). linked outcomes with follow-up October 31, 2021. We...
We report on a measurement of ϕ-meson production in Au+Au collisions at beam momentum 11.7AGeV∕c by experiment 917 the alternating gradient synchroton. The covers midrapidity region 1.2<y<1.6. Transverse-mass spectra and rapidity distributions are presented as functions centrality characterized number participant projectile nucleons. yield ϕ’s per nucleon increases strongly central manner similar to that observed for kaons.7 MoreReceived 21 April...
The impact parameter dependence of the disappearance directed transverse flow has been investigated for $^{40}\mathrm{Ar}$+$^{45}\mathrm{Sc}$ reactions using Michigan State University $4\ensuremath{\pi}$ Array upgraded with High Rate (HRA). energy at which collective in reaction plane disappears, balance (${E}_{\mathrm{bal}}$), is found to increase approximately linearly as a function parameter. Comparison our measured values ${E}_{\mathrm{bal}}(b)$ shows agreement predictions Quantum...
The extraction of source radii from heavy-ion collisions using coalescence models is explored. A new prescription presented which considers nucleosynthesis via the fragments is, in particular, more appropriate for intermediate-energy than previous nucleon prescriptions. This fragment model provides an avenue viewing breakup stage reactions that yields valuable complimentary information to two-nucleon and two-fragment correlation measurements. was applied recent experimental data on central...
We present results for antilambda and antiproton production in Au+Au collisions at 11.7 A GeV/c including spectra extracted invariant yields both species central peripheral the rapidity range 1.0<y<1.4. The yield increases from dN(Lambda;)/dy = 1.2(+0.7+0.2)(-0.6-0.2)x10(-3) to 19(+4+3)(-5-2)x10(-3) collisions. direct is deduced measured total extract ratio of antilambda-to-direct-antiproton production. Lambda/p near midrapidity 0.26(+0.19+0.5)(-0.15-0.4) 3.6(+4.7+2.7)(-1.8-1.1) collisions,...
Abstract Objectives Automatic job coding tools were developed to reduce the laborious task of manually assigning codes based on free-text descriptions in census and survey data sources, including large occupational health studies. The objective this study is provide a case comparative performance JEM (Job-Exposure Matrix)-assigned exposures agreement using existing tools. Methods We compared three automatic [AUTONOC, CASCOT (Computer-Assisted Structured Coding Tool), LabourR], which selected...
Mapping job titles to standardized occupation classification (SOC) codes is an important step in evaluating changes health risks over time as measured inspection databases. However, manual SOC coding cost prohibitive for very large studies. Computer based systems can improve the efficiency of incorporating occupational risk factors into large-scale epidemiological We present a novel method mapping verbatim using table prior knowledge available public domain that included detailed description...
Abstract After spinal cord injury (SCI), the “spared” tissue below lesion contains undamaged cells that could support or augment recovery, but targeting these requires a clearer understanding of their responses and capacity for repair. Here, we used single nucleus sequencing to profile how each cell type in lumbar changes over time after thoracic injury. We present an atlas dynamic explore two unexpected findings. Amongst neurons, rare types expressed molecular signature regeneration amongst...