A5063425761- Air Quality and Health Impacts
- Occupational and environmental lung diseases
- Carcinogens and Genotoxicity Assessment
- Carbon dioxide utilization in catalysis
- Occupational Health and Safety Research
- Radiopharmaceutical Chemistry and Applications
- Catalytic Processes in Materials Science
- Eicosanoids and Hypertension Pharmacology
- Cancer, Hypoxia, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Occupational exposure and asthma
- Toxic Organic Pollutants Impact
- Health, Environment, Cognitive Aging
- Indoor Air Quality and Microbial Exposure
- Pesticide Exposure and Toxicity
- Heavy Metal Exposure and Toxicity
- Air Quality Monitoring and Forecasting
- Pesticide and Herbicide Environmental Studies
- Environmental Justice and Health Disparities
- Sulfur Compounds in Biology
- Epigenetics and DNA Methylation
- Reliability and Agreement in Measurement
- Chemical Safety and Risk Management
- Odor and Emission Control Technologies
- Noise Effects and Management
National Cancer Institute
2016-2025
Division of Cancer Epidemiology and Genetics
2016-2025
National Institutes of Health
2012-2024
National Cancer Institute
2023
Society of Environmental Toxicology and Chemistry
2022
Vancouver Coastal Health
2021
National Cancer Institute
2019
Centre International de Recherche sur le Cancer
2018
United States Department of Health and Human Services
2011-2018
Office of the United Nations High Commissioner for Refugees
2016
<h3>Objectives</h3> Organophosphates (OPs) are among the most commonly used insecticides. OPs have been linked to cancer risk in some epidemiological studies, which largely conducted predominantly male populations. We evaluated personal use of specific and incidence female spouses pesticide applicators prospective Agricultural Health Study cohort. <h3>Methods</h3> At enrolment (1993–1997), provided information about ever pesticides, including 10 OPs, demographic information, reproductive...
Organochlorine insecticides (OCs) have historically been used worldwide to control insects, although most now banned in developed countries. Evidence for an association between OC exposures and cancer predominantly comes from occupational population based-studies among men. We evaluated the use of specific OCs female spouses pesticide applicators Agricultural Health Study. At enrollment (1993–1997), private cohort provided information about their own pesticides, including seven (aldrin,...
Increased pesticide concentrations in house dust agricultural areas have been attributed to several exposure pathways, including drift, para-occupational, and residential use.To guide future assessment efforts, we quantified relative contributions of these pathways using meta-regression models published data on concentrations.From studies North American from 1995 2015, abstracted reported as summary statistics [e.g., geometric means (GM)]. We analyzed mixed-effects that weighted each...
Parental occupational exposures to pesticides, animals and organic dust have been associated with an increased risk of childhood cancer based mostly on case-control studies. We prospectively evaluated parental leukemia central nervous system (CNS) tumors in the International Childhood Cancer Cohort Consortium. pooled data 329,658 participants from birth cohorts five countries (Australia, Denmark, Israel, Norway United Kingdom). during pregnancy were estimated by linking Standard...
Bladder cancer has been linked to several occupations that involve the use of solvents, including those used in dry-cleaning industry.
<h3>Objectives</h3> Metalworking has been associated with an excess risk of bladder cancer in over 20 studies. fluids (MWFs) are suspected as the responsible exposure, but epidemiological data limited. We investigated this association among men New England Bladder Cancer Study using state-of-the-art, quantitative exposure assessment methods. <h3>Methods</h3> Cases (n=895) and population controls (n=1031) provided occupational histories during personal interviews. For selected jobs,...
<h3>Background</h3> Mapping job titles to standardised occupation classification (SOC) codes is an important step in identifying occupational risk factors epidemiological studies. Because manual coding time-consuming and has moderate reliability, we developed algorithm called SOCcer (Standardized Occupation Coding for Computer-assisted Epidemiologic Research) assign SOC-2010 based on free-text description components. <h3>Methods</h3> Job title task-based classifiers were by comparing...
Objective To estimate the association between occupational polycyclic aromatic hydrocarbon (PAH) exposure and female breast cancer. Methods Lifetime work histories for 1130 cases 1169 controls from British Columbia Ontario (Canada) were assessed PAH using a job-exposure matrix based on compliance measurements obtained during US Occupational Safety Health Administration workplace safety inspections. Results Exposure to any level of PAHs was associated with an increased risk cancer (OR=1.32,...
Occupational exposures constitute the second leading cause of urinary bladder cancer after tobacco smoking. Increased risks have been found in petroleum industry, but high-quality exposure data are needed to explain these observations.Using a prospective case-cohort design, we analysed 189 cases (1999-2017) and 2065 randomly drawn non-cases from Norwegian Offshore Petroleum Workers cohort. Cases were identified Cancer Registry Norway, while work histories (1965-1998) lifestyle factors...
Abstract Background: Generic job-exposure matrices (JEMs) are often used in population-based epidemiologic studies to assess occupational risk factors when only the job and industry information of each subject is available. JEM ratings based on professional judgment, usually ordinal or semi-quantitative, do not account for changes exposure over time. We present an empirical Bayesian framework that combines subjective with benzene measurements. Our aim was better discriminate between job,...
We conducted a comprehensive humidifier disinfectant exposure characterization for 374 subjects with lung disease who presumed their was related to use (patient group) and 303 of family members (family an ongoing epidemiological study. visited the homes registered patients investigate characteristics. Probability disinfectants determined from questionnaire supporting evidence photographs demonstrating disinfectant, purchase receipts, any residual consistency statements. Exposure duration...
To assess the associations between occupational exposure to biocides and pesticides risk of thyroid cancer.Using data from a population-based case-control study involving 462 incident cancer cases 498 controls in Connecticut collected 2010-2011, we examined association with through job-exposure matrix. We used unconditional logistic regression models estimate OR 95% CI, adjusting for potential confounders.Individuals who were occupationally ever exposed had an increased (OR=1.65, CI 1.16...
Few studies have demonstrated gene/environment interactions in cancer research. Using data on high-risk occupations for 2258 case patients and 2410 control from two bladder studies, we observed that three of 16 known or candidate susceptibility variants displayed statistically significant consistent evidence additive interactions; specifically, the GSTM1 deletion polymorphism (Pinteraction ≤ .001), rs11892031 (UGT1A, Pinteraction = .01), rs798766 (TMEM129-TACC3-FGFR3, .03). There was limited...
The International Agency for Research on Cancer (IARC) classifies diesel engine exhaust as carcinogenic to humans based sufficient evidence lung cancer. IARC noted, however, an increased risk of bladder cancer (based limited evidence).To evaluate the association between quantitative, lifetime occupational exposure and urothelial cell carcinoma (UBC) overall according pathological subtypes.Data from personal interviews with 1944 UBC cases, well formalin-fixed paraffin-embedded tumor tissue...
Use of cleaning and disinfecting products is associated with work-related asthma among healthcare workers, but the specific levels factors that affect exposures remain unclear. The objective this study was to evaluate determinants selected volatile organic compound (VOC) in settings.Personal mobile-area air measurements (n = 143) from 100 workers at four hospitals were used model ethanol, acetone, 2-propanol, d-limonene, α-pinene, chloroform exposures. Hierarchical cluster analysis conducted...
Glyphosate is the most widely applied herbicide worldwide. biomonitoring data are limited for agricultural settings. We measured urinary glyphosate concentrations and assessed exposure determinants in Biomarkers of Exposure Effect Agriculture (BEEA) study. selected four groups BEEA participants based on self-reported pesticide exposure: recently exposed farmers with occupational use last 7 days (n = 98), high lifetime (>80th percentile) but no 70), farming controls minimal 100), nonfarming...