A5100621858- Invertebrate Immune Response Mechanisms
- Aquaculture disease management and microbiota
- Protist diversity and phylogeny
- Microbial Community Ecology and Physiology
- Plant Pathogens and Fungal Diseases
- Genomics and Phylogenetic Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Coral and Marine Ecosystems Studies
- Marine Bivalve and Aquaculture Studies
- Microbial Natural Products and Biosynthesis
- Marine Toxins and Detection Methods
- Marine Sponges and Natural Products
- Insect symbiosis and bacterial influences
- Marine Biology and Ecology Research
- Oral microbiology and periodontitis research
- Marine Invertebrate Physiology and Ecology
- Aquaculture Nutrition and Growth
- MicroRNA in disease regulation
- Subterranean biodiversity and taxonomy
- Plant Disease Resistance and Genetics
- Neurobiology and Insect Physiology Research
- Physiological and biochemical adaptations
- Perovskite Materials and Applications
- Advanced Drug Delivery Systems
- Chalcogenide Semiconductor Thin Films
Minjiang University
2017-2025
Fujian University of Traditional Chinese Medicine
2020-2025
Hong Kong Polytechnic University
2024
Fujian Agriculture and Forestry University
2024
Guangzhou Medical University
2012-2024
Stomatology Hospital
2020-2024
Ministry of Natural Resources
2019-2023
ZheJiang Academy of Agricultural Sciences
1999-2023
Fujian Institute of Oceanography
2011-2023
Army Medical College
2023
The signaling network of innate immunity in Drosophila is constructed by multiple evolutionarily conserved pathways, including the Toll- or Imd-regulated NF-κB and JNK pathways. p38 MAPK pathway stress responses, but its role host defense not fully understood. Here we show that also participates defense. In comparison with wild-type flies, sensitivity to microbial infection was slightly higher p38a mutant, significantly p38b unchanged p38c mutant. p38b;p38a double-mutant flies were...
Abstract There are disease-causing biohazards in the blood that cannot be treated with modern medicines. Here we show an intelligently designed safe biomaterial can precisely identify, tow and dump a targeted biohazard from into small intestine. Positively charged mesoporous silica nanoparticles (MSNs) functionalized EGFR-targeting aptamers (MSN-AP) specifically recognize bind blood-borne negatively oncogenic exosomes (A-Exo), A-Exo across hepatobiliary layers Oddi’s sphincter MSN-AP...
Goldfish have been subjected to over 1,000 y of intensive domestication and selective breeding. In this report, we describe a high-quality goldfish genome (2n = 100), anchoring 95.75% contigs into 50 pseudochromosomes. Comparative genomics enabled us disentangle the two subgenomes that resulted from an ancient hybridization event. Resequencing 185 representative variants 16 wild crucian carp revealed origin identified genomic regions shaped by sweeps linked its domestication. Our...
Four novel compounds, chaephilone C (1), chaetoviridides A-C (2-4), were obtained from the culture of a deep sea derived fungus Chaetomium sp. NA-S01-R1, together with four known compounds-chaetoviridin A (5), chaetoviridine E (6), chaetomugilin D (7) and cochliodone (8). Their structures, including absolute configurations, assigned based on NMR, MS time-dependent density functional theory (TD-DFT) ECD calculations. plausible biogenetic pathway for compounds 1-3 was proposed. Compounds 2 3...
BackgroundCellular hypoxia, if severe enough, results usually in injury or cell death. Our research this area has focused on the molecular mechanisms underlying hypoxic tissue to explore strategies prevent enhance tolerance. The current experiments were designed determine genetic basis for adaptation long term low O2 environments.Methodology/Principal FindingsWith experimental selection over many generations, we obtained a Drosophila melanogaster strain that can live perpetually extremely...
All-inorganic double perovskites as promising photovoltaic materials have received great attention in recent years.
Three novel compounds, 4-methyl-candidusin A (1), aspetritone (2) and B (3), were obtained from the culture of a coral-derived fungus Aspergillus tritici SP2-8-1, together with fifteen known compounds (4-18). Their structures, including absolute configurations, assigned based on NMR, MS, time-dependent density functional theory (TD-DFT) ECD calculations. Compounds 2 5 exhibited better activities against methicillin-resistant strains S. aureus (MRSA) ATCC 43300 MRSA CGMCC 1.12409 than...
(1) Background: Animal growth is a complex process, involving the coordination of wide variety genes, non-coding RNAs, and pathways. Circular RNAs (circRNAs) belong to novel class functional (ncRNAs). They have distinctive ring structure are involved in various biological processes, including proliferation, differentiation, apoptosis muscle cells. The Pacific abalone Haliotis discus hannai an economically valuable mollusk species cultivated China. However, modulation by circRNAs this poorly...
Reproduction and breeding are crucial to maintaining abalone aquaculture. Understanding the molecular underpinnings of sexual maturation is essential for advancing knowledge in reproductive biology. However, mechanisms gonadal development abalones remain poorly understood, particularly microRNA (miRNA)-mediated regulation. Thus, this study conducted a comprehensive transcriptomic analysis Haliotis discus hannai (H. hannai) identify genes miRNAs associated with ovarian testicular discovery....
Two novel compounds, 2-hydroxy-6-formyl-vertixanthone (1) and 12-O-acetyl-sydowinin A (2), were obtained from the culture of a deep sea-derived fungus Aspergillus sydowii C1-S01-A7, together with twenty-two known compounds (3–24). Their structures elucidated based on extensive spectroscopic methods. Compounds 4, 8 12 showed antibacterial activities against Vibrio rotiferianus vulnificus. 1, 2, 7, 8, 11 exhibited activity methicillin-resistant Staphylococcus aureus. Remarkably, compound...
Horseshoe crabs are ancient marine arthropods with a long evolutionary history extending back approximately 450 million years, which may benefit from their innate immune systems. However, the genetic mechanisms underlying abilities of distinguishing and defending against invading microbes still unclear.Here, we describe 2.06 Gbp genome assembly Tachypleus tridentatus 24,222 predicted protein-coding genes. Comparative genomics shows that T. Atlantic horseshoe crab Limulus polyphemus have most...
Vestimentifera (Polychaeta, Siboglinidae) is a taxon of deep-sea worm-like animals living in hydrothermal vents, cold seeps, and organic falls. The morphology lifespan Ridgeia piscesae, which the only vestimentiferan tubeworm species found vents on Juan de Fuca Ridge, vary greatly according to endemic environment. Recent analyses have revealed genomic basis adaptation three vent- seep-dwelling tubeworms. However, evolutionary history mechanism R. unique family Siboglinidae, remain be...