A5100438150- Genomics and Phylogenetic Studies
- Protist diversity and phylogeny
- Aquaculture disease management and microbiota
- Subterranean biodiversity and taxonomy
- Invertebrate Immune Response Mechanisms
- Coral and Marine Ecosystems Studies
- Monoclonal and Polyclonal Antibodies Research
- Microbial Community Ecology and Physiology
- interferon and immune responses
- Marine Biology and Ecology Research
- Fullerene Chemistry and Applications
- Non-Invasive Vital Sign Monitoring
- Immune Response and Inflammation
- Marine and coastal plant biology
- Glycosylation and Glycoproteins Research
- Marine Sponges and Natural Products
- Ocean Acidification Effects and Responses
- Cell death mechanisms and regulation
- Galectins and Cancer Biology
- Developmental Biology and Gene Regulation
- Marine Biology and Environmental Chemistry
- Innovative Microfluidic and Catalytic Techniques Innovation
- Sensorless Control of Electric Motors
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Bioactive Compounds and Antitumor Agents
Guangzhou Electronic Technology (China)
2025
Fujian Institute of Oceanography
2015-2024
Ministry of Natural Resources
2013-2024
Shanghai Institute of Optics and Fine Mechanics
2023
Chinese Academy of Sciences
2023
Ministry of Water Resources of the People's Republic of China
2014-2020
Jiangsu Ocean University
2018-2019
Minjiang University
2019
Chinese National Human Genome Center at Shanghai
2019
Fudan University
2019
Tumor necrosis factor α (TNFα), an important clinical testing and drug target, can trigger serious autoimmune diseases inflammation. Thus, the TNFα antibodies have great potential application in diagnostics therapy fields. The variable binding domain of IgNAR (VNAR), shark single antibody, has some excellent advantages terms size, solubility, thermal chemical stability, making them ideal alternative to conventional antibodies. This study aims obtain VNARs that are specific for mouse TNF...
Abstract In the South China Sea, coastal eutrophication in Beibu Gulf has seriously threatened reef habitats by subjecting corals to chronic physiological stress. To determine how coral holobionts may tolerate such conditions, we examined transcriptomes of healthy colonies galaxy Galaxea fascicularis and its endosymbiont Symbiodinium from two sites experiencing pristine or eutrophied nutrient regimes. We identified 236 205 genes that were differentially expressed hosts symbionts,...
Horseshoe crabs are ancient marine arthropods with a long evolutionary history extending back approximately 450 million years, which may benefit from their innate immune systems. However, the genetic mechanisms underlying abilities of distinguishing and defending against invading microbes still unclear.Here, we describe 2.06 Gbp genome assembly Tachypleus tridentatus 24,222 predicted protein-coding genes. Comparative genomics shows that T. Atlantic horseshoe crab Limulus polyphemus have most...
The chemical examination of the solid cultures deep-sea-derived fungus Penicillium chrysogenum MCCC 3A00292 resulted in isolation three new versiol-type analogues, namely peniciversiols A–C (1–3), and two novel lactone derivatives, penicilactones A B (6 7), along with 11 known polyketides. planar structures compounds were determined by comprehensive analyses high-resolution electrospray ionization mass spectroscopy (HRESIMS) nuclear magnetic resonance (NMR) data, while their absolute...
Vestimentifera (Polychaeta, Siboglinidae) is a taxon of deep-sea worm-like animals living in hydrothermal vents, cold seeps, and organic falls. The morphology lifespan Ridgeia piscesae, which the only vestimentiferan tubeworm species found vents on Juan de Fuca Ridge, vary greatly according to endemic environment. Recent analyses have revealed genomic basis adaptation three vent- seep-dwelling tubeworms. However, evolutionary history mechanism R. unique family Siboglinidae, remain be...
N-(Rhodamine B)-benzimidazole (RB-IM), featuring an intramolecular spiro-benzimidazole, was developed for selective sensing of protons via opening the spiro-ring to give fluorescent and colored species. The utility RB-IM demonstrated by imaging lysosomes in live cells staining intestine zebrafish.
Fullerene (C60) derivatives, a unique class of compounds with potent antioxidant properties, have been reported to exert wide variety biological activities including neuroprotective properties. Mitochondrial dynamics are an important constituent cellular quality control and function, imbalance the eventually leads mitochondria disruption cell dysfunctions. This study aimed assess effects carboxylic acid C60 derivatives (C60-COOH) on mitochondrial elucidate its associated mechanisms in...
Vital signs, such as heart rate (HR), variability (HRV), respiratory (RR), are important indicators for a person's health. signs traditionally measured with contact sensors, and may be inconvenient cause discomfort during continuous monitoring. Commercial cameras promising contact-free remote photoplethysmography (rPPG) have been studied to remotely monitor from face videos. For RR measurement, most prior art was based on small periodical motions of chest regions caused by breathing cycles,...
The p38 pathway is an evolutionarily conserved signaling that responds to a variety of stresses. However, the underlying mechanisms are largely unknown. In present study, we demonstrate p38b major MAPK involved in regulation oxidative stress tolerance addition p38a and p38c Drosophila. We further show importance MK2 as p38-activated downstream kinase resistance Furthermore, identified iron-sulfur cluster scaffold protein IscU new substrate both Drosophila cells mammalian cells. These results...
Immunoglobulin new antigen receptor (IgNAR) is a naturally occurring antibody that consists of only two heavy chains with independent variable domains. The binding domain IgNAR, called (VNAR), attractive due to its solubility, thermal stability, and small size. Hepatitis B surface (HBsAg) viral capsid protein found on the virus (HBV). It appears in blood an individual infected HBV widely used as diagnostic marker for infection. In this study, whitespotted bamboo sharks (Chiloscyllium...
The horseshoe crab Tachypleus tridentatus is a unique marine species and potential model for invertebrate. Limited genomic transcriptional data are currently available to understand the molecular mechanisms underlying embryonic development of T. tridentatus. Here, we reported first time de novo transcriptome assembly at developmental stage using Illumina RNA-seq platform. Approximate 38 million reads were obtained further assembled into 133,212 unigenes. Sequence homology analysis against...
A nonsingular high-order terminal sliding-mode observer of interior permanent magnet synchronous motor (IPMSM) is presented, which the state variable current rotor-oriented d-q reference frame, to obtain accurate information about angular speed and rotor position for high-performance vector control system. used improve dynamic response robustness observer, sliding mode method adopted estimate chattering phenomenon conventional sliding-mode. Meanwhile, regulator parameters loop, an...
Robot-assisted cell manipulation is gaining attention for its ability in providing high throughput and precision the biological industry. This paper presents a visual servo microrobotic system microinjection. We investigated automatic autofocus method that reduced complexity of system. Then, we produced an adaptive processing algorithm to detect location micropipette toward uneven illumination problem. Fourteen microinjection experiments were conducted with zebrafish embryos. A 100% success...
Prion disorders are progressive neurodegenerative diseases characterized by extensive neuronal loss, which is linked to the extracellular accumulation of scrapie isoform (PrPSC) normal cellular prion protein (PrPC). As microglial activation a central event in pathogenesis disease, strategies that reduce may have therapeutic benefits. In this study, neuroprotective effects hydroxylated C60(C60-OH) and amino modified-C60(C60-NH2) were evaluated using PrP(106-126)-stimulated BV-2 cells as model...
Mammalian autophagy-related gene 13 (ATG13) is a vital component of the ATG1 autophagy initiation complex which plays an essential role in autophagy. However, molecular function ATG13 pathogen defense invertebrates still poorly understood. In this study, full-length cDNA sequence blood clam Tegillarca granosa (TgATG13) was obtained, 1,918 bp length, including 283 5' UTR, 252 3' UTR and 1,383 open reading frame (ORF) encoding 460 amino acids. Phylogenetic analysis revealed that TgATG13 had...