A5100779369- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Drug Solubulity and Delivery Systems
- Dental materials and restorations
- Dental Implant Techniques and Outcomes
- Cancer therapeutics and mechanisms
- Erythrocyte Function and Pathophysiology
- Natural Compounds in Disease Treatment
- Pharmacological Effects of Natural Compounds
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Plant-based Medicinal Research
- Glioma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Reconstructive Facial Surgery Techniques
- Hydrogels: synthesis, properties, applications
- Dendrimers and Hyperbranched Polymers
- Monoclonal and Polyclonal Antibodies Research
- Characterization and Applications of Magnetic Nanoparticles
- Field-Flow Fractionation Techniques
- Click Chemistry and Applications
- Pancreatic and Hepatic Oncology Research
Fujian University of Traditional Chinese Medicine
2022-2025
Inner Mongolia Medical University
2024
Shanghai Skin Disease Hospital
2023
Tongji University
2023
Fudan University
2023
Osaka University
2012-2020
Antibody drug conjugates (ADCs) have emerged as a new promising class of anti- cancer agents. However, limitations such higher costs and unavoidable immunogenicity due to their relatively large structures cannot be ignored. Therefore, the development lightweight drugs small molecule–drug (SMDCs) based on ADC design idea has become option for targeted therapy. SMDCs are derived from coupling small-molecule targeting ligands with cytotoxic drugs. They composed three parts: ligands, molecules,...
In continuing search for effective treatments of cancer, the emerging model aims at efficient intracellular delivery therapeutics into tumor cells in order to increase drug concentration. However, implementation this strategy suffers from inefficient cellular uptake and resistance. Therefore, pH-sensitive nanosystems have recently been developed target slightly acidic extracellular pH environment solid tumors. The targeting approach is regarded as a more general than conventional specific...
Tumour targeting nanotechnology has recently made therapeutic progress and several nanoparticles have been approved for clinical application. However, an ideal based solid tumours, particularly systemic administration, still remains a challenge in cancer therapy. We previously reported pH sensitive vivo delivery system of doxorubicin, or microRNA, using carbonate apatite (CA) nanoparticles. To further explore utility CA therapy, we attempted to transport excess glucose into tumour cells by...
The aim of this study is to investigate the internal morphology all-ceramic prostheses before seating. Micro X-ray CT was used inspect three dimensionally locations and sizes pores within experimentally fabricated crowns as well measure veneer core thickness. Scanning electron microscopy (SEM) examine fracture sites clinically failed prostheses. analysis revealed distribution patterns prostheses, SEM fractographic indicated a strong relationship between existence crack propagation....
As is well-known, due to the complex pathogenesis of pancreatic cancer, monotherapy alone no longer sufficient meet current treatment goals. Combination drug therapy shows greater potential compared monotherapy. Paclitaxel (PTX) and gemcitabine (GEM) are frequently used together treat various types cancers. However, two drugs differ significantly in their physical chemical properties, simple coadministration can lead severe toxic side effects. In this study, liposome technology was employed...
The prognosis of pancreatic cancer (PCa) is extremely poor because its resistance to conventional therapies. Many previous studies have demonstrated that triptolide (TPL) has a potent tumoricidal activity on PCa. However, the clinical application TPL in tumor therapy been greatly limited by aqueous solubility, short half-time, high toxicity and inefficient delivery. Here, through engineering prodrug technology combined with nanodrug-delivery system (NDDS) strategy, we modified main active...