A5074605624- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Diet and metabolism studies
- Primate Behavior and Ecology
- Gut microbiota and health
- Evolutionary Psychology and Human Behavior
- Intracerebral and Subarachnoid Hemorrhage Research
- Online Learning and Analytics
- Advanced Text Analysis Techniques
- Functional Brain Connectivity Studies
- Sentiment Analysis and Opinion Mining
- Second Language Acquisition and Learning
- Recommender Systems and Techniques
- Intelligent Tutoring Systems and Adaptive Learning
- Lexicography and Language Studies
- Reinforcement Learning in Robotics
- Regulation of Appetite and Obesity
- Neural dynamics and brain function
- Natural Language Processing Techniques
- Topic Modeling
- scientometrics and bibliometrics research
- Text and Document Classification Technologies
- Complex Network Analysis Techniques
- Open Education and E-Learning
The Affiliated Yongchuan Hospital of Chongqing Medical University
2013-2024
Chongqing University
2022-2024
Chongqing Medical University
2013-2024
Chongqing Three Gorges University
2022-2024
Chongqing Three Gorges Central Hospital
2023-2024
Xuzhou Medical College
2022-2023
Jilin University
2023
First Hospital of Jilin University
2023
Beijing Normal University
2014-2022
Chinese Institute for Brain Research
2021-2022
The inflammation and oxidative stress (OS) have been considered crucial components of the pathogenesis depression. Edaravone (EDA), a free radical scavenger, processes strong biological activities including antioxidant, anti-inflammatory neuroprotective properties. However, its role potential molecular mechanisms in depression remain unclear. present study aimed to investigate antidepressant activity EDA underlying mechanisms.A chronic social defeat (CSDS) model was performed explore whether...
Background The cynomolgus monkey (Macaca fascicularis) has been increasingly used in biomedical research, making knowledge of its blood-based parameters essential to support the selection healthy subjects and use preclinical research. As age sex affect these parameters, it is important establish baseline indices for on an basis determine effects indices. Methods A total 917 monkeys (374 males 543 females) were selected segregated by (five groups) sex. 30 hematological 22 biochemical...
Abstract Our previous work has shown that d -ribose (RIB)-induced depressive-like behaviors in mice. However, the relationship between variations RIB levels and depression as well potential participation depressive disorder is yet unknown. Here, a reanalysis of metabonomics data from depressed patients model rats performed to clarify whether increased level positively correlated with severity depression. Moreover, we characterize intestinal epithelial barrier damage, gut microbial...
Depression is a complex psychiatric disorder. Various depressive rodent models are usually constructed based on different pathogenesis hypotheses.Herein, using our previously established naturally occurring (NOD) model in non-human primate (cynomolgus monkey, Macaca fascularis), we performed metabolomics analysis of cerebrospinal fluid (CSF) from NOD female macaques (N=10) and age-and gender-matched healthy controls (HCs) (N=12). Multivariate statistical was used to identify the...
State-of-the-art (SOTA) reinforcement learning (RL) methods enable the vision-language agents to learn from interactions with environment without human supervision. However, they struggle inefficiencies in tackling real-world complex sequential decision-making tasks, especially sparse reward signals and long-horizon dependencies. To effectively address issue, we introduce Variational Subgoal-Conditioned RL (VSC-RL), which reformulates task as a variational goal-conditioned problem, allowing...
Abstract Rodent models have dominated preclinical investigations into the mechanisms of depression. However, these models-which rely on subjecting individual rodents to physical stressors - do not realistically resemble etiopathological development depression, which occurs naturally in a social context. A non-human primate model that better reflects ethological aspects depression would be more advantageous investigating pathophysiological and developing antidepressant therapeutics. Here, we...
Hepatic steatosis is a major health issue that can be attenuated by healthy diet. This study investigates the effects and molecular mechanisms of butyrate, dietary fiber metabolite gut microbiota, on lipid metabolism in hepatocytes.
Information exchange between neurons and astrocytes mediated by extracellular vesicles (EVs) is known to play a key role in the pathogenesis of central nervous system diseases. A driver epilepsy dysregulation intersynaptic excitatory neurotransmitters astrocytes. Thus, we investigated potential association neuronal EV microRNAs (miRNAs) astrocyte glutamate uptake ability epilepsy. Here, showed that were able engulf epileptogenic EVs, inducing significant increase concentration fluid...
Major depressive disorder (MDD) is a debilitating psychiatric mood that affects millions of individuals globally. Our understanding the biological basis MDD poor, and current treatments are ineffective in significant proportion cases. This situation may relate to dominant rodent animal models depression, which possess translational limitations due limited homologies with humans. Therefore, more homologous primate model depression needed advance investigation into pathophysiological...
The cynomolgus monkey (Macaca fascicularis) has been increasingly used in biomedical research. Although living conditions affect behavioral and physiological characteristics macaques, little data is available on how influence blood-based parameters the monkey. We hypothesize that there are significant differences serum biochemical hematological single-caged versus socially housed monkeys, age sex effect of these parameters. Sixty 60 monkeys were segregated by group (juvenile, adult) sex....
Recent depression research has revealed a growing awareness of how to best classify into depressive subtypes. Appropriately subtyping can lead identification subtypes that are more responsive current pharmacological treatment and aid in separating out depressed patients which antidepressants not particularly effective. Differential co-expression analysis (DCEA) differential regulation (DRA) were applied compare the transcriptomic profiles peripheral blood lymphocytes from with two subtypes:...
Background The cynomolgus monkey (Macaca fascicularis) has been increasingly used as a non-human primate model in biomedical research. As establishing baseline thoracic radiography for the is essential, we tested hypothesis that age and sex may affect parameters of this species. Methods Here, 697 healthy monkeys were segregated by (three groups: 25–36 months, 37–48 49–60 months). lung length (LL), maximal interior depth (TD), breadth (TBr), cardiac silhouette (CBr), cardiothoracic ratio...
The oxytocin effects on large-scale brain networks such as Default Mode Network (DMN) and Frontoparietal (FPN) have been largely studied using fMRI data. However, these studies are mainly based the statistical correlation or Bayesian causality inference, lacking interpretability at physical neuroscience level. Here, we propose a physics-based framework of Kuramoto model to investigate phase dynamic neural coupling in DMN FPN. Testing data 59 participants administrated with either placebo,...
In advertising studies, the impact of sexually appealing advertisements (hereafter "ads") on consumers' product preferences is highly controversial. This paper explores (1) how such ads affect at gazing stage (initial exposure to ad) and evaluation (final preference), (2) which type (utilitarian vs. hedonic) more suited ads. We used an electroencephalogram record participants' self-reported stage. The results indicated that participants preferred with high sex appeal low Further, compared...
The world has encountered and witnessed the great popularity of various emerging e-learning resources such as massive open online courses (MOOCs), textbooks videos with development big data era. It is critical to understand characteristics users assist them find desired relevant learning in a large volume resources. For example, understanding pre-knowledge on vocabulary learners very prominent useful for language systems. effectiveness can be significantly improved if levels accurately...
Major depressive disorder (MDD) in adolescents is a widespread and growing global public health concern with unique characteristics pathophysiological mechanisms that are distinct from MDD adults.The purpose of our work was to address this knowledge gap about the adolescent depression microbiota-gut-brain (MGB) axis perspective.Ten healthy male cynomolgus macaques (Macaca fascicularis) were paired into five pairs based on age body weight, two each pair randomly allocated chronic...