A5086081945- Migraine and Headache Studies
- Vestibular and auditory disorders
- Ophthalmology and Eye Disorders
- Trigeminal Neuralgia and Treatments
- Pain Mechanisms and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Biochemical effects in animals
- Nicotinic Acetylcholine Receptors Study
- Neurological Disease Mechanisms and Treatments
- Neuroscience of respiration and sleep
- Neuroinflammation and Neurodegeneration Mechanisms
- Glaucoma and retinal disorders
- Adenosine and Purinergic Signaling
- Vagus Nerve Stimulation Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cerebrovascular and Carotid Artery Diseases
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Cerebral Venous Sinus Thrombosis
- S100 Proteins and Annexins
- Traumatic Brain Injury and Neurovascular Disturbances
- Hearing, Cochlea, Tinnitus, Genetics
- Neurological Disorders and Treatments
- Psychosomatic Disorders and Their Treatments
- Neuropeptides and Animal Physiology
The Affiliated Yongchuan Hospital of Chongqing Medical University
2016-2025
Chongqing Medical University
2016-2025
Soochow University
2024
First Affiliated Hospital of Soochow University
2024
Children's Hospital of Chongqing Medical University
2016-2018
Chinese Institute for Brain Research
2017
Chongqing Public Health Medical Center
2017
Chongqing University
2016
Beijing Xuanwu Traditional Chinese Medicine Hospital
2006
University of Pittsburgh
1993
Central sensitization is an important mechanism of chronic migraine (CM) and related to the inflammatory response microglia. The NOD-like receptor protein 3 (NLRP3) inflammasome may regulate process microglia in several neurological diseases, but its role CM largely unknown. Therefore, aim this study was identify precise microglial NLRP3 CM. An experimental mouse model established by repeated intraperitoneal (i.p) injection with nitroglycerin (NTG). We evaluated expression levels downstream...
According to our previous study, microglia P2X4 receptors (P2X4Rs) play a pivotal role in the central sensitization of chronic migraine (CM). However, molecular mechanism that underlies crosstalk between P2X4Rs and neurons trigeminal nucleus caudalis (TNC) is not fully understood. Therefore, aim this study examine exact signalling pathway development CM animal model.We used an model with recurrent intermittent administration nitroglycerin (NTG), which closely mimics CM. NTG-induced basal...
Microglial activation contributes to the development of chronic migraine (CM). The P2Y12 receptor (P2Y12R), a metabolic purinoceptor that is expressed on microglia in central nervous system (CNS), has been indicated play critical role pathogenesis pain. However, whether it mechanism CM remains unknown. Thus, present study investigated precise details microglial P2Y12R involvement CM.Mice subjected recurrent nitroglycerin (NTG) treatment were used as model. Hyperalgesia assessed by mechanical...
Previous studies have confirmed that the microglial activation and subsequent inflammatory responses in trigeminal nucleus caudalis (TNC) are involved central sensitization of chronic migraine (CM). MicroRNA-155-5p has been shown to modulate polarization microglia participate processes a variety neurological diseases. However, its role CM remains unclear. The purpose this study was determine precise miR-155-5p CM.A model C57BL/6 mice established by recurrent intraperitoneal injection...
Identification of the trigger factors headache could be an important aspect preventive management, but characteristics primary triggers in China are unknown. This study was performed to estimate frequencies putative triggers, which endorsed by patients with migraine and tension-type (TTH).From July 2011 December 2011, a cross-sectional survey conducted neurological clinic tertiary care hospital Chongqing. All consecutive chief complaint were interviewed board-certified specialist. The...
Objectives This study explored the clinical characteristics of vestibular migraine in Chinese subjects and performed a field test criteria International Classification Headache Disorders 3rd edition beta version. Methods Consecutive patients with were surveyed registered headache clinic during period. The diagnosis was made according to Assessments included standardized neuro-otology bedside examination, pure-tone audiogram, bithermal caloric testing, neurological imaging, cervical X-ray or...
The mechanism underlying migraine chronification remains unclear. Central sensitization may account for this progression. microglia P2X4 receptor (P2X4R) plays a pivotal role in the central of inflammatory and neuropathic pain, but there is no information about P2X4R migraine. Therefore, aim study was to identify precise chronic (CM).We used an animal model with recurrent intermittent administration nitroglycerin (NTG), which closely mimics CM. NTG-induced basal acute mechanical...
To investigate the prevalence of and personal professional characteristics associated with burnout, psychological morbidity, job stress, satisfaction in Chinese neurologists.The China Neurologist Association conducted a national cross-sectional study from September 2014 to March 2015. A questionnaire including Maslach Burnout Inventory, 12-item General Health Questionnaire, Consultants' Mental questions assessing characteristics, career satisfaction, current doctor-patient relationships was...
Background. Persistent postural-perceptual dizziness (PPPD) is a common vestibular disorder. This study was conducted to assess whether the addition of cognitive behavior therapy (CBT) could significantly improve efficacy and acceptability sertraline in treating PPPD. Methods. PPPD patients were recruited randomly assigned control experiment groups. Patients both groups received 50–200 mg/day, only group CBT (twice week, one hour per time). The treatment continued for eight weeks. At...
Abstract Background Central sensitization is an important pathophysiological mechanism of chronic migraine (CM). According to our previous studies, microglial activation and subsequent inflammation in the trigeminal nucleus caudalis (TNC) contribute central sensitization. The P2X7 receptor (P2X7R) a purinergic expressed microglia participates pain, but its role CM unclear. Numerous studies have shown that P2X7R regulates level autophagy affects inflammation. Recently, has been be involved...
Vestibular symptoms are frequently reported in patients with chronic migraine (CM). However, whether vestibular arise through overlapping neurobiology of remains to be elucidated. The neuropeptide calcitonin gene-related peptide (CGRP) and CGRP1 receptor play important pathological roles facilitating central sensitization CM. Therefore, we aimed investigate contributes dysfunction after CM by improving synaptic transmission the nucleus (VN).A rat model was established recurrent intermittent...
Objective Previous studies of neuropathic pain have suggested that the P2X4 purinoceptor (P2X4R) in spinal microglia is essential for maintaining allodynia following nerve injury. However, little known about its role inflammatory soup-induced trigeminal allodynia, which closely mimics chronic migraine status. Here, we determined contributions P2X4R and related signaling pathways an model. Methods gene protein levels nucleus caudalis were analyzed repeated dural soup infusions. p38,...
Abstract Background Vestibular migraine has recently been recognized as a novel subtype of migraine. However, the mechanism that relate vestibular symptoms to had not well elucidated. Thus, present study investigated dysfunction in rat model chronic (CM), and dissect potential mechanisms between vertigo. Methods Rats subjected recurrent intermittent administration nitroglycerin (NTG) were used CM model. Migraine- vestibular-related behaviors analyzed. Immunofluorescent analyses quantitative...
Evidence suggests that the activation of α7 nicotinic acetylcholine receptor (α7nAChR) can greatly decrease neuroinflammation response. Neuroinflammation plays a pivotal role in pathogenesis chronic migraine (CM). Clinical observations also show nicotine gum induces analgesic effects patients. However, whether α7nAChR is involved CM unclear.To investigate and provide new therapeutic target for CM.Thirty-six male Sprague-Dawley rats were distributed randomly into control, CM, PNU-282987,...
Abstract Background The pathogenesis of chronic migraine remains unresolved. Recent studies have affirmed the contribution GLUA1-containing AMPA receptors to migraine. dopamine D2 receptor, a member G protein-coupled receptor superfamily, has been proven an analgesic effect on pathological headaches. present work investigated exact role in and its trafficking. Methods A model was established by repeated inflammatory soup stimulation. Mechanical, periorbital, thermal pain thresholds were...
ABSTRACT Chronic migraine (CM) is a disabling neurological disease. Astragaloside IV (AS‐IV), natural product derived from Astragalus membranaceus , shows great potential in treating chronic pain by relieving inflammation and oxidative stress. This study aimed to investigate the effects mechanisms of action AS‐IV on CM. An inflammatory soup comprising histamine, bradykinin, serotonin, prostaglandin E2 was used establish CM rat model, while lipopolysaccharide applied induce an response...
Abstract Background Central sensitization is one of the characters chronic migraine (CM). Aberrant synaptic plasticity can induce central sensitization. Oxytocin (OT), which a hypothalamic hormone, plays an important antinociceptive role. However, effect OT and underlying mechanism in CM remains unclear. Therefore, we explored on its implying mechanism, focusing plasticity. Methods A mouse model was established by repeated intraperitoneal injection nitroglycerin (NTG). Von Frey filaments...
Abstract Background Central sensitization is an important pathophysiological mechanism of chronic migraine (CM), and microglia activation in trigeminocervical complex (TCC) contributes to the development central sensitization. Emerging evidence implicates that blocking sphingosine-1-phosphate receptor 1 (S1PR1) can relieve pain inhibit microglia. However, it unclear whether S1PR1 involved CM. Therefore, purpose this study explore role its downstream signal transducers activators...
This study aimed to investigate the prevalence and risk factors for anxiety depression symptoms in outpatient migraineurs mainland China. In addition, we evaluated whether Hospital Anxiety Depression Scale (HADS) provided sufficient validity screen anxiety. A cross-sectional was conducted consecutively at our headache clinic. Migraine diagnosed according International Classification of Headache Disorders, 2nd edition (ICHD-II). Demographic characteristics clinical features were collected by...
The aim of this study was to assess the quality life (QOL) Chinese home-based advanced-stage cancer patients and evaluate association between disclosure diagnosis QOL. An interview-based survey conducted from December 2009 June 2010 in hospice First Affiliated Hospital Chongqing Medical University, China. principal finding demonstrated that who did not have knowledge their exhibited better physical emotional QOL compared with those had diagnosis.
Abstract Background The mechanism of chronic migraine (CM) is complex, central sensitization considered as one the pathological mechanism. Synaptic plasticity basis sensitization. Metabotropic glutamate receptor 5 (mGluR5) plays a vital role in synaptic nervous system. However, whether mGluR5 can promote by regulating CM unknown. Methods Male Wistar rats were used to establish rat model, and expression mRNA protein detected qRT-PCR western blot. allodynia was assessed mechanical thermal...
We studied mutations of the adult voltage-gated skeletal muscle sodium channel gene in 12 families, from diverse ethnic backgrounds, with hyperkalemic periodic paralysis (HyperPP). describe a novel procedure, using ligase chain reaction (LCR), to simultaneously identify two different point (previously described) and one rare, apparently benign polymorphism that results nonconservative amino acid substitution. Three families showed Metl592Val mutation, six had Thr704Met mutation. The mutation...