A5101758258- Pain Mechanisms and Treatments
- Migraine and Headache Studies
- Barrier Structure and Function Studies
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Inflammatory mediators and NSAID effects
- Mitochondrial Function and Pathology
- Cholesterol and Lipid Metabolism
- Inflammasome and immune disorders
- Traditional Chinese Medicine Analysis
- Wnt/β-catenin signaling in development and cancer
- Cell Adhesion Molecules Research
- Neuroinflammation and Neurodegeneration Mechanisms
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024-2025
Chongqing Medical University
2024-2025
Hunan University of Traditional Chinese Medicine
2024
First Affiliated Hospital of Zhengzhou University
2017
Stroke remains the leading cause of death and disability worldwide.This fact highlights need to search for potential drug targets that can reduce stroke-related brain damage.We showed recently a glycogen synthase kinase-3β (GSK-3β) inhibitor attenuates tissue plasminogen activator-induced hemorrhagic transformation after permanent focal cerebral ischemia.Here, we examined whether GSK-3β inhibition mitigates early ischemia-reperfusion stroke injury investigated its mechanism action.We used...
ABSTRACT Chronic migraine (CM) is a disabling neurological disease. Astragaloside IV (AS‐IV), natural product derived from Astragalus membranaceus , shows great potential in treating chronic pain by relieving inflammation and oxidative stress. This study aimed to investigate the effects mechanisms of action AS‐IV on CM. An inflammatory soup comprising histamine, bradykinin, serotonin, prostaglandin E2 was used establish CM rat model, while lipopolysaccharide applied induce an response...
Chronic migraine is a disabling disorder without effective therapeutic medicine. AMPA receptors have been proven to be essential pathological pain and headaches, but the related regulatory mechanisms in chronic not yet explored. In this study, we found that level of surface GluA2 was reduced rats. Tat-GluR23Y (a endocytosis inhibitor) calcium inward flow weakened synaptic structures, thus alleviating migraine-like sensitization. addition, inhibition influx alleviated mitochondrial overload...