A5101701600- Andrographolide Research and Applications
- Lung Cancer Treatments and Mutations
- Ginseng Biological Effects and Applications
- Lung Cancer Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- Intracerebral and Subarachnoid Hemorrhage Research
- Tea Polyphenols and Effects
- Cancer Immunotherapy and Biomarkers
- Phytoestrogen effects and research
- Natural product bioactivities and synthesis
- Neurological Disease Mechanisms and Treatments
- Vascular Malformations Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Antiplatelet Therapy and Cardiovascular Diseases
- Ginkgo biloba and Cashew Applications
- Pneumonia and Respiratory Infections
- Lymphoma Diagnosis and Treatment
- Phytochemistry and Biological Activities
- Phytochemicals and Antioxidant Activities
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Toxin Mechanisms and Immunotoxins
- Genomics, phytochemicals, and oxidative stress
Chongqing Three Gorges University
2022-2025
Chongqing University
2022-2025
Xian Yang Central Hospital
2024
The Second Nanning People's Hospital
2024
Tianjin Medical University General Hospital
2019-2021
Guangdong Academy of Medical Sciences
2017-2021
Guangdong General Hospital
2015-2021
Wannan Medical College
2020
First Affiliated Hospital of Wannan Medical College
2020
Guangdong Provincial People's Hospital
2019
Two new flavonoid glycosides, 5-hydroxy-7,8-dimethoxy (2R)-flavanone-5-O-β-D-glucopyranoside (1) and 5-hydroxy-7,8,2′,5′-tetramethoxy-flavone-5-O-β-D-glucopyranoside (2), a diterpenoid, andrographic acid (3), along with andrographidine A (4) were isolated from Andrographis paniculata, their structures determined on the basis of physicochemical spectroscopic analysis. Compound 3 was evaluated for cytotoxicity to KB cells andrographolide, isoandrographolide, neoandrographolide...
Abstract Caffeic acid derivatives occurring in black cohosh [ Cimicifuga racemosa (L.) Nutt., Actaea (Ranunculaceae)], some of which may have pharmacological activity, were analyzed using high‐performance liquid chromatography (HPLC) electrospray ionization tandem mass spectrometry (ESI‐MS/MS) with the aim developing a methodology for their rapid identification complex plant matrix. Based on these studies, structurally characteristic product ions and neutral molecule losses identified, then...
Glioblastoma multiforme (GBM) is a refractory tumor with poor prognosis and requires more effective treatment regimens. It has been confirmed that long noncoding RNAs (lncRNAs) substantially regulate various human disease including GBM. However, the biological roles its underlying molecular mechanisms still need to be further investigated. In this study, function potential mechanism of lncHAS2-AS1 in GBM were explored. was discovered HAS2-AS1 elevated glioma tissues correlated patients...
The aim of this study was to assess the pharmacokinetics (PK) and safety/tolerability siponimod in healthy subjects when coadministered with (1) moderate cytochrome P450 (CYP) 2C9 CYP3A inhibitor fluconazole (Study A), (2) three different CYP2C9 genotype variants B). Study A an open-label, single-dose comprising periods 1 (14 days; day 1: 4 mg) 2 (20 200 mg twice daily; days 2–19: once 3: (n = 14) wild-type (CYP2C9*1/*1). B a multicentre, open-label parts (day 0.25 daily CYP2C9*1/*1,...
As a result of bioactivity-guided search for novel, plant-derived cancer chemopreventive agents, ixocarpalactone A (5) was isolated previously as potent quinone reductase inducer from the leaves and stems Physalis philadelphica. In present study, this promising lead compound reisolated in gram quantities vivo biological testing. During course work, four additional minor new withanolides were also obtained characterized, namely, 2,3-dihydro-3β-methoxyixocarpalactone (1), B (2),...
A rapid, sensitive and specific LC-MS-MS method has been developed for the determination of clarithromycin (CLA) in human plasma using roxithromycin (ROX) as internal standard. Samples were prepared via liquid–liquid extraction with methyl tert-butyl ether (MTBE) chromatographed on a Supelco RP18 (4.6 × 50 mm, 3 µm particle size) column mobile phase consisting acetonitrile:methanol:60 mM (pH 3.5) ammonium acetate buffer (32.5:32.5:35) at constant flow rate 0.8 mL/min. The run time was min...
Abstract The present paper describes the development of an HPLC–PDA method for simultaneous determination bioactive diterpenoids, andrographolide, isoandrographolide, neoandrographolide, and 14‐deoxy‐11,12‐didehydroandrographolide in plant materials commercial products Andrographis paniculata. Separations were achieved using a conventional C18 column with PDA detection at 200–400 nm UV spectrum 225 quantification. mobile phase consists water acetonitrile varying from 20% to 50% over 40 min....
ABSTRACT Ginkgo biloba products are one of the top ten botanical dietary supplements in USA. The active constituents include flavonoids and terpene lactones (ginkgolides bilobalide). have been associated with reduced lipid peroxidation vascular walls nerve cells. Ginkgolides well known to be antagonists platelet-activating factor (PAF). Usually, enriched ginkgo extracts used for preparation standardized contain 24% 6% lactones. In present work, we examined nine commercial content total by...
The somatostatin analog pasireotide and the 11β-hydroxylase inhibitor osilodrostat (LCI699) reduce cortisol levels by distinct mechanisms of action. There exists a scientific rationale to investigate clinical efficacy these two agents in combination. This manuscript reports results toxicology study rats, evaluating different doses alone Sixty male 60 female rats were randomized into single-sex groups receive daily (0.3mg/kg/day, subcutaneously), (20mg/kg/day, orally),...
In response to concerns that commercial dietary supplements containing Ginkgo biloba (ginkgo) and Echinacea purpurea, angustifolia, or pallida (echinacea) might be contaminated with colchicine, a highly selective sensitive assay was developed for colchicine is based on high-performance liquid chromatography-tandem mass spectrometry (LC-MS-MS). The method utilizes reversed-phase HPLC separation of compounds in methanolic extract the supplement botanical sample followed by positive ion...
Analysis of two commercial extracts Andrographis paniculata using high-performance liquid chromatography (HPLC) with photodiode array absorbance detection showed the presence several unexpected compounds, which were isolated and identified as methyl, ethyl, propyl esters p-hydroxybenzoic acid by high-resolution mass spectrometry nuclear magnetic resonance. Quantitative analysis HPLC revealed 0.22% methyl ester (methlyparaben) in one extract, both 0.11% ethyl (ethylparaben) 0.20%...
An HPLC-UV method with gradient elution for the quantification of catechins [(+)-catechin, (−)-epicatechin and gallate] in grape seed extract was developed. The presence monomers, dimers, and/or trimers catechin were assayed an initial HPLC-APCI-MS analysis, which followed by isolation, purification, characterization spectral (NMR MS) analyses compounds interest. results confirmed above monomers extract. Three peaks interest chromatogram identified to be gallic acid, procyanidin-B4,...
ABSTRACT A reverse-phase high performance liquid chromatographic method is developed for the determination of andrographolide, a characteristic diterpene lactone in commercial Andrographis (Andrographis paniculata) products. Samples are analyzed by means column (Supelco Discovery C18) using acetonitrile and water, under gradient conditions as mobile phase, over 40 min. The evaporative light scattering detector (ELSD) used, was set at an evaporating temperature 61°C nebulizing gas (compressed...