A5064645750- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Extracellular vesicles in disease
- Neurological Disorders and Treatments
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Angiogenesis and VEGF in Cancer
- Cerebrovascular and Carotid Artery Diseases
- S100 Proteins and Annexins
- Cerebrospinal fluid and hydrocephalus
- Advanced Glycation End Products research
- Neurogenesis and neuroplasticity mechanisms
- Circular RNAs in diseases
- Barrier Structure and Function Studies
- Alzheimer's disease research and treatments
- Drug Transport and Resistance Mechanisms
- Neonatal and fetal brain pathology
- Peroxisome Proliferator-Activated Receptors
- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Cardiac Fibrosis and Remodeling
Henry Ford Hospital
2015-2024
Henry Ford Health System
2016-2023
Michigan State University
2023
Poornima University
2013-2021
Mahatma Gandhi Medical College and Research Institute
2018
Oakland University
2013-2017
Tianjin Medical University General Hospital
2015-2017
Saneron CCEL Therapeutics (United States)
2015
University of Rochester
2014-2015
Michigan United
2013
Background and Purpose- Stroke patients with type 2 diabetes mellitus (T2DM) exhibit increased vascular white matter damage have worse prognosis compared nondiabetic stroke patients. We investigated the neurorestorative effects of exosomes derived from mouse brain endothelial cells (EC-Exo) as treatment for in T2DM mice role miR-126 mediating EC-Exo-derived therapeutic benefits T2DM-stroke mice. Methods- Adult, male BKS.Cg-m+/+Leprdb/J were subjected to photothrombotic model. intravenously...
Abstract Diabetes mellitus (DM) is a high risk factor for stroke and leads to more severe vascular white-matter injury than in non-DM. We tested the neurorestorative effects of delayed human umbilical cord blood cell (HUCBC) treatment type-2 diabetes (T2DM). db/db-T2DM db/+-non-DM mice were subjected distal middle cerebral artery occlusion (dMCAo) treated 3 days after dMCAo with: (a) non-DM + Phosphate buffered saline (PBS); (b) T2DM PBS; (c) naïve-HUCBC; (d) miR-126−/−HUCBC. Functional...
Abstract In rats with type 1 diabetes (T1DM), the therapeutic effects and underlying mechanisms of action stroke treatment were compared between bone-marrow stromal cells (BMSCs) derived from T1DM (DM-BMSCs) BMSCs normal (Nor-BMSCs). The novel role microRNA-145 (miR-145) in mediating DM-BMSC treatment-induced benefits was also investigated. (n = 8 per group) underwent 2 hours middle cerebral artery occlusion (MCAo) treated 24 later one following (5 × 106 administered i.v.): (a)...
Background and Purpose— Diabetes mellitus is a high-risk factor for ischemic stroke. Diabetic stroke patients suffer worse outcomes, poor long-term recovery, risk of recurrent strokes, extensive vascular damage. We investigated the neurorestorative effects underlying mechanisms treatment with human umbilical cord blood cells (HUCBCs) in type 2 diabetes (T2DM) rats. Methods— Adult male T2DM rats were subjected to hours middle cerebral artery occlusion (MCAo). Three days after MCAo, treated...
Vascular dementia (VaD) affects cognition and memory. MicroRNA-126 (miR-126) is an angiogenic microRNA that regulates vascular function. In this study, we employ a multiple microinfarction (MMI) model to induce VaD in mice, investigate VaD-induced cognitive dysfunction, white matter (WM) damage, glymphatic dysfunction the role of miR-126 mediating these effects. Male six-to eight-months old C57/BL6 mice (WT) were subject MMI model, cerebral blood flow (CBF), vessel patency, function, serum...
Summary Stroke is a global health concern and it imperative that therapeutic strategies with wide treatment time frames be developed to improve neurological outcome in patients. Patients diabetes mellitus who suffer stroke have worse outcomes long-term functional recovery than nondiabetic Diabetes induced vascular damage enhanced inflammatory milieu likely contributes post outcomes. Diabetic patients an aggravated pathological cascade, treatments benefit do not necessarily translate diabetic...
Cardiovascular complications are common after traumatic brain injury (TBI) and associated with increased morbidity mortality. In this study, we investigated the possible role of immune system in mediating cardiac dysfunction post-TBI mice. Adult male C57BL/6J mice were subjected to a TBI model controlled cortical impact (CCI) or without splenectomy (n = 20/group). Splenectomy was performed immediately prior induction TBI. Cardiac function measured using echocardiography Neurological...
Stroke induces cardiac dysfunction which increases post stroke mortality and morbidity particularly in aging population. Here, we investigated the effects of inflammatory responses as underlying mediators after adult mice. Adult (eight-to-nine months) male C57BL/6 mice were subjected to photothrombotic stroke. To test whether immunoresponse leads dysfunction, splenectomy was performed with Immunohistochemistry, flow cytometry, PCR, ELISA echocardiography performed. We found marginal at acute...
Summary Background and purpose We investigated the neurorestorative effects underlying mechanisms of stroke treatment with human umbilical cord blood cells ( HUCBC s) in Type one diabetes mellitus (T1 DM ) rats. Methods rats were subjected to middle cerebral artery occlusion MCA o) 24 h later treated with: (1) phosphate‐buffered‐saline; (2) s. Brain endothelial MBEC cultured capillary tube formation was measured. Results Human significantly improved functional outcome promoted white matter...
Background and Purpose— Comorbidity of diabetes mellitus stroke results in worse functional outcome, poor long-term recovery, extensive vascular damage. We investigated the neurorestorative effects mechanisms treatment with human bone marrow–derived mesenchymal stromal cells (hMSCs) type 2 (T2DM) rats. Methods— Adult male Wistar rats were induced T2DM, subjected to hours middle cerebral artery occlusion (MCAo) treated via tail-vein injection (1) PBS (n=8) (2) hMSCs (n=10; 5×10 6 ) at 3 days...
Vascular Dementia (VaD) accounts for nearly 20% of all cases dementia. eNOS plays an important role in neurovascular remodeling, anti-inflammation, and cognitive functional recovery after stroke. In this study, we investigated whether regulates brain damage, function mouse model bilateral common carotid artery stenosis (BCAS) induced VaD. Late-adult (6-8 months) C57BL/6J knockout (eNOS-/-) mice were subjected to BCAS (n=12/group) or sham group (n=8/group). was performed by applying...
ATP-binding cassette transporter A1 (ABCA1) is a major reverse cholesterol and plays critical role in the formation of brain high-density lipoprotein (HDL) cholesterol. Apolipoprotein E (ApoE) most abundant apolipoprotein transports into cells brain. ABCA1 ApoE are upregulated by liver-X receptors. Activation receptors has neurorestorative benefit for stroke. The current study investigates whether ABCA1/ApoE/HDL pathway mediates GW3965, synthetic dual receptor agonist, induced...
Chronic subdural hematoma (CSDH) is a neurological disorder with substantial recurrence rate. Atorvastatin an effective drug for treating hyperlipidemia and known to improve outcome after intracerebral hemorrhage. Previous studies have reported that atorvastatin treatment promotes absorption in CSDH, while the underlying mechanisms remain unclear. In this study, we investigated whether anti-inflammatory effects of mediate CSDH. 144 male, Wistar rats (6 months old) were randomly divided into...