A5071779537- Signaling Pathways in Disease
- Autophagy in Disease and Therapy
- Cancer Immunotherapy and Biomarkers
- Endoplasmic Reticulum Stress and Disease
- Cell death mechanisms and regulation
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- interferon and immune responses
- Spine and Intervertebral Disc Pathology
- Cancer-related molecular mechanisms research
- Connective Tissue Growth Factor Research
- NF-κB Signaling Pathways
- Natural product bioactivities and synthesis
- Parathyroid Disorders and Treatments
- Mesenchymal stem cell research
- vaccines and immunoinformatics approaches
- Wnt/β-catenin signaling in development and cancer
- Protease and Inhibitor Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Musculoskeletal pain and rehabilitation
- Calpain Protease Function and Regulation
- Ubiquitin and proteasome pathways
- Nerve injury and regeneration
- Congenital heart defects research
- Systemic Sclerosis and Related Diseases
Nanjing Medical University
2023-2025
Shanghai First People's Hospital
2023-2025
Yale University
2023-2024
Xi'an Jiaotong University
2007-2023
Xi'an Honghui Hospital
2017-2023
University of Hong Kong
2021-2023
Shanghai Jiao Tong University
2023
General Hospital of Jinan Military Command
2010-2018
State Key Laboratory of Cancer Biology
2010-2015
Air Force Medical University
2010-2015
Immune checkpoint inhibitors, such as anti-PD-1/PD-L1, are a novel class of inhibitors that function tumor suppressing factor via modulation immune cell-tumor cell interaction. To date, PD-1/PD-L1 have been approved for the treatment specific types tumors and obtained good clinical efficacy. However, patients with osteosarcoma showed poor response to anti-PD-1/PD-L1 therapy, mechanism which is not well understood. In this study, we found tissues were heavily infiltrated by myeloid-derived...
Abstract Tumor cells can move as individual in two interconvertible modes: mesenchymal mode and amoeboid mode. Cytoskeleton rearrangement plays an important role the interconversion. Previously, we reported that HAb18G/CD147 annexin II are interacting proteins involved cytoskeleton rearrangement, yet of their interaction is unclear. In this study found depletion produced a rounded morphology, which associated with movement, whereas resulted elongated movement. The extracellular portion...
The efficacy of immune checkpoint blockade (ICB) therapy depends on sufficient infiltration and activation primed tumor-specific cytotoxic T lymphocytes (CTLs) in the tumor microenvironment. However, many types, including osteosarcoma, mainly display immune-desert or immune-excluded phenotypes, which are characterized by a lack tumor-infiltrating poor response to ICB monotherapy. Thus, novel therapeutic strategies urgently needed surmount these obstacles. In this study, we found that...
Abstract Neoantigens are derived from somatic mutations in the tumors but absent normal tissues. Emerging evidence suggests that neoantigens can stimulate tumor-specific T-cell-mediated antitumor immune responses, and therefore potential immunotherapeutic targets. We developed ImmuneMirror as a stand-alone open-source pipeline web server incorporating balanced random forest model for neoantigen prediction prioritization. The was trained tested using known immunogenic neopeptides collected 19...
The objective of this study was to identify key secretory protein-encoding differentially expressed genes (SP-DEGs) in adipose tissue female metabolic syndrome, thus detecting potential targets treatment. We examined gene expression profiles 8 women with syndrome and 7 healthy, normal body weight women. A total 143 SP-DEGs were screened, including 83 upregulated 60 downregulated genes. GO analyses these included proteolysis, angiogenesis, positive regulation endothelial cell proliferation,...
Fat infiltration within marrow cavity is one of multitudinous features estrogen deficiency, which leads to a decline in bone formation functionality. The origin this fat unclear, but possibility that it derived from osteoblasts, transdifferentiate into adipocytes produce fat. We examined the dose-dependent effect 17β-estradiol on ability MC3T3-E1 cells and murine marrow-derived mesenchymal stem cell (BMMSC)-derived osteoblasts undergo osteo-adipogenic transdifferentiation. found...
Apoptosis of bone marrow-derived mesenchymal stem cells (BMMSCs) is an essential pathogenic factor osteoporosis. Ginsenoside-Rb2 (Rb2), a 20(S)-protopanaxadiol glycoside extracted from ginseng, potent treatment for loss, which raises interest regarding the metabolism area. In present study, we found that dose-response Rb2 inhibited high dosage dexamethasone (Dex)-induced apoptosis in primary murine BMMSCs. Interestingly, promoted GPR120 induction, unsaturated long-chain fatty acid receptor....
Glucocorticoid‑induced osteoporosis (GIOP) is a widespread clinical complication following glucocorticoid therapy. This irreversible damage to bone‑forming and ‑resorbing cells essential in the pathogenesis of osteoporosis. Autophagy physiological process involved regulation their responses diverse stimuli, however, role autophagy glucocorticoid‑induced bone marrow mesenchymal stem (BMSCs) remains unclear. The current study confirmed that administration impaired proliferation BMSCs....
Abstract Calpains are a conserved family of calcium‐dependent cysteine proteinases involved in various cellular functions. Two ubiquitous isoforms, µ‐ and m‐calpain, key members the calpain that play essential roles regulating cell migration invasion. However, it remains unclear whether they progression hepatocellular carcinoma (HCC). Here, we investigated functions m‐calpain invasive metastatic processes human hepatoma cells. Our results indicated expression levels calpains were elevated...
Osteosarcoma, the most common primary bone tumor in children and young adolescents, is characterized by local invasion distant metastasis. But detailed mechanisms of osteosarcoma metastasis are not well known. In present study, we found that βig-h3 promotes metastatic potential human cells vitro vivo. Furthermore, co-localized with integrin α2β1 cells. did change expression Saos-2 Interaction mediates The second FAS1 domain but first domain, third or fourth metastasis, which...
The long-term use of dexamethasone (Dex), a well-known immunosuppressant, leads to an imbalance in bone metabolism and rapid decline mineral density due apoptosis osteoblasts. molecular mechanisms by which Dex induces osteoblast remain unclear.MC3T3-E1 cells were treated with 0, 10-8, 10-6, 10-4 M for 24 h. ATF6, phosphorylated PERK, IRE1, IRE1 expression, cell apoptosis, caspase-12 caspase-3 activity measured. CHOP expression calcium ion influx rate measured 0 effect 2-APB treatment was...
Neuronal damage or degeneration is the main feature of neurological diseases. Regulation neurogenesis and neuronal differentiation important in developing therapies to promote regeneration synaptic network reconstruction. Neurogenesis a multistage process which neurons are generated integrated into existing circuits. extremely complex because it can occur different cell types be caused by variety inducers. Recently, natural compounds that induce have attracted extensive attention. In this...
Metabolic syndrome (MS) has a high prevalence in hemodialysis patients. High asprosin levels are associated with the accumulation of adiposity and an increase body weight, which may drive development this syndrome. The relationship between MS patients on not been investigated.We enrolled at center one hospital May 2021. was defined by International Diabetes Federation. Fasting serum were measured. ROC curve, multivariate logistic regression Spearman's rank correlation analyses performed.In...
Background. Secondary hyperparathyroidism is a universal complication of chronic renal diseases. One the pathological consequences impairment interstitium and tubules. However, molecular mechanism tubular interstitial induced by parathyroid hormone (PTH) remains unclear. Enhanced prolonged expression connective tissue growth factor (CTGF) has been associated with fibrosis inflammation in kidney. The purpose this study was to investigate effects PTH on CTGF patterns human proximal cell...
Bladder cancer-associated protein (BLCAP) is a novel candidate tumor suppressor gene identified from human bladder carcinoma and highly associated with the invasion of cancer. We previously reported that it also plays key role in tumorigenesis metastasis osteosarcoma. In present study, we constructed recombinant encoding BLCAP cDNA. Overexpression resulted growth inhibition induced apoptosis TC-135 Ewing's sarcoma cells vitro. further investigated caspase-3/7 activity expressions fusion...