A5101535580- Cancer, Hypoxia, and Metabolism
- Heart Rate Variability and Autonomic Control
- Pharmacological Effects and Toxicity Studies
- Glioma Diagnosis and Treatment
- Genetic Syndromes and Imprinting
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Nitric Oxide and Endothelin Effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell Adhesion Molecules Research
- Stress Responses and Cortisol
- High Altitude and Hypoxia
- Biochemical effects in animals
- Menopause: Health Impacts and Treatments
- Ubiquitin and proteasome pathways
- Retinal Development and Disorders
- Mitochondrial Function and Pathology
- Lung Cancer Treatments and Mutations
- Cardiovascular Issues in Pregnancy
- Cardiac electrophysiology and arrhythmias
- Histone Deacetylase Inhibitors Research
- Dental Implant Techniques and Outcomes
- Mental Health Treatment and Access
- Heme Oxygenase-1 and Carbon Monoxide
- Acupuncture Treatment Research Studies
Xinqiao Hospital
2025
Army Medical University
2019-2024
Nanjing Medical University
2024
Jiangsu Province Hospital
2024
82th Hospital of Pla
2023
North Sichuan Medical University
2023
Jinan Military General Hospital
2017
Xijing Hospital
2000-2014
Air Force Medical University
2000-2014
Second Military Medical University
2003-2004
Summary Aims Stroke is a major cause of mortality and disability, especially for postmenopausal women. In view the protective action estrogen, hormone therapy remains only effective way to limit this risk. The objective study was investigate efficiency underlying mechanisms estrogen neuroprotection. Methods Subcutaneous injection 17β‐estradiol in rats after ovariectomy ( OVX ) used manipulate level explore effects cerebral ischemic damage both vivo vitro. Silent mating type information...
Research highlights poor mental health among healthcare workers, but limited attention has been given to the literacy and professional psychological help-seeking attitudes of primary workers.This study investigates relationship between workers' their toward help-seeking. It also explores chain mediating roles social support illness stigma in this relationship. We conducted workers Shapingba District, Chongqing, China. The utilized demographic questionnaires, Multiple Mental Health Literacy...
To determine whether perturbations of haemostatic function and lipoprotein metabolism prevail long after preeclampsia increase the risk future coronary heart disease (CHD), we conducted a follow-up study in women with (cases, n = 25) or without (controls, 24) history preeclampsia. Blood samples were taken follicular luteal phases menstrual cycle. Levels blood pressure (BP) proteinuria measured during index pregnancy included evaluation. Compared to control who had undergone normal pregnancy,...
Osteosarcoma, the most common primary bone tumor in children and young adolescents, is characterized by local invasion distant metastasis. But detailed mechanisms of osteosarcoma metastasis are not well known. In present study, we found that βig-h3 promotes metastatic potential human cells vitro vivo. Furthermore, co-localized with integrin α2β1 cells. did change expression Saos-2 Interaction mediates The second FAS1 domain but first domain, third or fourth metastasis, which...
Hypoxia is a predominant feature in glioblastoma (GBM) and contributes greatly to its drug resistance. However, the molecular mechanisms which are responsible for development of resistant phenotype GBM under hypoxic conditions remain unclear. To analyze key pathways promoting therapy resistance GBM, we utilized U87-MG cell line as human model brain HEB non-neoplastic model. These lines were cultured presence 21, 5, 1% O 2 24 h. We detected changes transcriptional profiling analyzed...
Objective The present study was designed to test the hypothesis that inflammation is involved in end-organ damage (EOD) induced by sinoaortic denervation (SAD) rats. Method SAD performed male Sprague–Dawley rats at age of 10 weeks. Under anaesthesia, aortic nerves were cut and sinus region carotid artery stripped painted with 10% phenol. Pathological evaluation EOD determination plasma or tissue levels factors related inflammation, including thromboxane B2 (TXB2) interleukin-1 (IL-1), tumour...
Long B, Dan L, Jian Yunyu H, Shu Zhi Y. Evaluation of a novel reconstituted bone xenograft using processed bovine cancellous in combination with purified morphogenetic protein. Xenotransplantation 2012; 19: 122–132. © 2012 John Wiley & Sons A/S. Abstract: Background: Xenogeneic grafting represents an alternative to autogenous osseous reconstruction and exhibits many beneficial properties. However, the usefulness xenogeneic relies on necessary processing procedures for removing antigens...
SUMMARY 1. Aconitine is widely used to produce ventricular arrhythmias in anaesthetized rats. The present work was designed test the hypothesis that anaesthesia may increase susceptibility of arrhythmia aconitine due inhibition arterial baroreflex. In addition, at different times during course a whole day also investigated. 2. Male Sprague‐Dawley rats were used. Arrhthymias induced by infusion six time points (01.00, 05.00, 09.00, 13.00, 17.00 and 21.00 h) with both conscious states....
Since the end of 1980s, pathological importance baroreflex function has attracted attention many investigators. In our previous studies, it was found that ketanserin lowered blood pressure (BP), decreased BP variability and enhanced sensitivity (BRS). The present work designed to test hypothesis restoration BRS by is not dependent on level in conscious rats.Spontaneously hypertensive rats (SHR) aged 8-12 months were used. Blood recorded for 60 min determined separately before after...
This study was designed to investigate the possible synergism of atenolol and amlodipine on lowering stabilizing blood pressure (BP) in spontaneously hypertensive rats. Sixty-four rats were randomly divided into eight groups. They given 0.8% carboxymethylcellulose sodium (control), (10 mg/kg), (0.5, 1 2 mg/kg) combinations + 0.5, 10 respectively. The drugs via a catheter gastric fistula. BP recorded for 25 h from before drug administration 24 after administration, conscious, freely moving It...
As a hallmark for glioblastoma (GBM), high heterogeneity causes variety of phenotypes and therapeutic responses among GBM patients, it contributes to treatment failure. Moreover, hypoxia is predominant feature greatly its phenotype. To analyse the landscape gene expression hypoxic characteristics cells their clinical significance in we performed transcriptome analysis cell line U87-MG normal glial HEB under normoxia conditions, with results which were analysed using established ontology...
Circular RNAs are associated with cardiovascular disease, including coronary artery but the mechanisms have not been completely elucidated. We found a new protein, circBTBD7-420aa, encoded by hsa_circ_0000563. Our results suggest that circBTBD7-420aa may inhibit abnormal proliferation and migration of human smooth muscle cells promoting SLC3A2 degradation through ubiquitin-proteasome pathway. In addition, we constructed engineered exosomes loaded can target vascular modifying peptide...
Coronary artery disease (CAD) has become a dominant economic and health burden worldwide, the role of autophagy in CAD requires further clarification. In this study, we comprehensively revealed association between flux from multiple hierarchies. We explored autophagy-associated long noncoding RNA (lncRNA) mechanisms underlying oxidative stress-induced human coronary endothelial cells (HCAECs) injury.
Anesthesia inhibits arterial baroreflex functions such as sensitivity (BRS). The main objective of the present study was to determine time course BRS recovery from anesthesia and whether is synchronous with consciousness blood pressure (BP). Experiments were performed in male Sprague-Dawley rats using different commonly used anesthetics at routine doses through intraperitoneal administration: (1) diazepam/ketamine, a mixture diazepam (5 mg/kg) ketamine (50 mg/kg); (2) chloral hydrate (0.3...
For post-menopausal women, stroke is complicated by the variable effects of estrogen therapy and age-related therapeutic consequences involved. Estrogen has been shown to have an age-dimorphic effect, which neuroprotective in young females, but non-neuroprotective, even neurotoxic acyclic females. We hypothesized that arterial baroreflex (ABR) its downstream acetylcholine-α7 nicotinic acetylcholine receptor (α7nAChR) anti-inflammatory pathways are involved efficacy toward cerebral ischemic...
Abstract Background Studies have revealed the protective effect of DL-3-n-butylphthalide (NBP) against diseases associated with ischemic hypoxia. However, role NBP in animals hypobaric hypoxia has not been elucidated. This study investigated effects on rodents acute and chronic Methods Sprague-Dwaley rats Kunming mice administered (0, 60, 120, 240 mg/kg for 0, 90, 180, 360 mice) were placed a chamber at 10,000 m survival percentages 30 min determined. Then, time distance to exhaustion...
Bisphosphoglycerate mutase (BPGM) is expressed in human erythrocytes and responsible for the production of 2,3-bisphosphoglycerate (2,3-DPG). However, expression role BPGM other cells have not been reported. In this work, we found that was significantly upregulated astrocytes upon acute hypoxia, phenomenon will be clarified following report.The mRNA protein levels content 2,3-DPG with hypoxia treatment were determined vitro vivo. Furthermore, glycolysis evaluated hypoxic knockdown normoxic...
Abstract Glucose–insulin–potassium (GIK) is clinically used for reducing mortality in acute myocardial infarction (MI). It known that ventricular arrhythmia, left dysfunction and impaired baroreflex sensitivity (BRS) are the three major determinants predicting after MI. The present work was designed to study effects of GIK on BRS, function rats with coronary artery ligature. Sprague–Dawley were produced by ligature anterior descending artery. Five weeks ligation, BRS measured conscious state...
Purpose N-acetylserotonin (NAS) can reduce retinal ischemia–reperfusion injury (RIRI) by inhibiting the TLR4/NF-κB/NLRP3 signaling pathway. Aflibercept is an anti-VEGF drug used to treat a variety of eye diseases. This study was performed investigate effect combination therapy with and aflibercept on RIRI its mechanism.