A5100761375- Sulfur Compounds in Biology
- Analytical Methods in Pharmaceuticals
- Anodic Oxide Films and Nanostructures
- Nitric Oxide and Endothelin Effects
- Renin-Angiotensin System Studies
- Mosquito-borne diseases and control
- Inflammatory mediators and NSAID effects
- Drug-Induced Adverse Reactions
- Biochemical effects in animals
- Neuroscience of respiration and sleep
- Pharmacovigilance and Adverse Drug Reactions
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Veterinary Pharmacology and Anesthesia
- Acute Ischemic Stroke Management
- PARP inhibition in cancer therapy
- Monoclonal and Polyclonal Antibodies Research
- Antioxidant Activity and Oxidative Stress
- Autophagy in Disease and Therapy
- Cell death mechanisms and regulation
- Systemic Lupus Erythematosus Research
- Aluminum Alloy Microstructure Properties
- Nicotinic Acetylcholine Receptors Study
- Blood Pressure and Hypertension Studies
- Tannin, Tannase and Anticancer Activities
Tongji Hospital
2010-2024
Tongji University
2006-2024
Shanghai First People's Hospital
2009-2010
Renji Hospital
2006
CAO Group (United States)
2003
Ca2+/calmodulin-dependent protein kinase II (CaMKII) plays a critical role in the development of heart failure and induction myocardial mitochondrial injury. Recent evidence has shown that hydrogen sulfide (H2S), produced by enzyme cystathionine γ-lyase (CSE), improves cardiac function failure. However, cellular mechanisms for this remain largely unknown. The present study was conducted to determine functional H2S protecting against dysfunction through inhibition CaMKII using wild type CSE...
Therapeutic strategies that increase hydrogen sulfide (H2S) or nitric oxide (NO) are cytoprotective in various models of cardiovascular injury. However, the nature interaction between H2S and NO heart failure underlying mechanisms for protective effects remain undefined. The present study tested cardioprotective effect ZYZ-803, a novel synthetic H2S-NO hybrid molecule decomposed to release NO. ZYZ-803 dose dependently improved left ventricular remodeling preserved function setting...
Hydrogen sulfide (H2S), the third gasotransmitter, plays a critical role in protecting against heart failure. Sirtuin-1 (SIRT1) is highly conserved histone deacetylase that has protective treatment of failure by regulating deacetylation some functional proteins. This study investigates interaction between SIRT1 and H2S underlying mechanisms.Using endogenous H2S-generating enzyme cystathionine γ-lyase (CSE) knockout mice, we found CSE deficiency aggravated isoprenaline-induced cardiac injury....
Luteolin, a naturally occurring polyphenol flavonoid, has demonstrated some beneficial modulation toward the endothelium. This study aims to investigate effects of luteolin on lysophosphatidylcholine (LPC)-induced apoptosis, key event in pathogenesis atherosclerosis, endothelial cells. Luteolin reduced not only LPC-induced cell death but also lactate dehydrogenase (LDH) leakage. inhibition apoptosis cells its protection against cytotoxicity LPC. is characterized by calcium-dependent...
Osteosarcoma is the most common type of bone cancer. In present study, by way PCR-based microarrays, we found that TUT1, a nucleotidyl transferase, was significantly downregulated in osteosarcoma, compared with adjacent normal tissues. current performed microarrays using cDNA prepared from osteosarcoma and The enforced expression TUT1 able to inhibit cell proliferation U2OS MG63 cells, while its knockdown small interfering RNA (siRNA) oligos promoted proliferation. At molecular level, could...
Background Currently, there remains substantial controversy in research regarding whether the concomitant use of colchicine and statins increases occurrence rhabdomyolysis, warranting further substantiation. Objective This study aimed to identify likelihood drug-drug interactions (DDIs) for co-administration resulting rhabdomyolysis. Methods A disproportionality analysis was conducted by using data sourced from US Food Drug Administration Adverse Event Reporting System (FAERS) detect...
Ischemic stroke incidence is increasing amongst elderly patients in China; this closely associated with drug-related problems (DRPs).To evaluate the influencing factors of DRPs among a history ischemic Chinese community and role clinical pharmacists play providing solutions.This study was conducted 2 health service centers Putuo District, Shanghai, China, between December 2018 June 2019. Demographics characteristics 130 selected were collected. Drug-related classified using Pharmaceutical...
This article covers current methods and applications in chiral analysis from 2010 to 2020 for biosamples clinical research forensic toxicology. Sample preparation aqueous solid biological samples prior instrumental were discussed the article. GC, HPLC, capillary electrophoresis sub/supercritical fluid chromatography provide efficient tools drug coupled fluorescence, UV MS detectors. The application of is article, which involves differentiation between use abuse, pharmacokinetic studies,...
Summary This study was designed to investigate the possible synergism of amlodipine and candesartan on reduction blood pressure ( BP ) in hypertensive rats. The end organ protection also observed. In acute experiment, spontaneously rats SHR s) were treated with intragastric administration (0.5, 1, 2, 3 mg/kg), (1, 3, 4, 6, 8 14 different combinations find ratio synergistic interaction. two kidneys, one clip (2K1C) rats, effects (1 canderastan (2 mg/kg) their combination chronic study, s for...
Fractional flow reserve (FFR) is considered nowadays as the gold standard for invasive assessment of physiologic stenosis significance and an indispensable tool decision-making in coronary revascularization.Robust studies have shown that FFR more effective accurately identifying which lesions should be stented, revascularization guided by improves outcome artery disease patients.Therefore, has been upgraded to a class A recommendation current guidelines when ischemic potential specific...