A5090205225- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Cancer-related gene regulation
- RNA modifications and cancer
- Magnesium Alloys: Properties and Applications
- Ubiquitin and proteasome pathways
- Pluripotent Stem Cells Research
- Aluminum Alloys Composites Properties
- RNA Research and Splicing
- Metal complexes synthesis and properties
- RNA and protein synthesis mechanisms
- Cancer, Lipids, and Metabolism
- Glycosylation and Glycoproteins Research
- CRISPR and Genetic Engineering
- Ferrocene Chemistry and Applications
- Electronic Packaging and Soldering Technologies
- Sperm and Testicular Function
- Monoclonal and Polyclonal Antibodies Research
- Gene Regulatory Network Analysis
- NF-κB Signaling Pathways
- Invertebrate Immune Response Mechanisms
- Metallurgical and Alloy Processes
- Ferroptosis and cancer prognosis
- Acupuncture Treatment Research Studies
- Islanding Detection in Power Systems
Shantou University
2017-2024
Shantou University Medical College
2017-2024
Hubei University of Medicine
2022-2024
Chongqing Medical University
2024
Taihe Hospital
2022-2024
University of Michigan
2024
Broad Center
2017-2022
University of California, Los Angeles
1970-2022
National University of Singapore
2022
Inserm
2019
Myocarditis, a health-threatening heart disease, is attracting increasing attention. This systematic study was conducted to the prevalence of disease through trends incidence, mortality, disability-adjusted life years (DALYs) over last 30 years, which would be helpful for policymakers better choices reasonable decisions.The global, regional, and national burdens myocarditis from 1990-2019 were analyzed by using 2019 Global Burden Disease (GBD) database. on produced new findings according...
Bone morphogenetic protein (BMP) signaling plays a crucial role in maintaining the pluripotency of mouse embryonic stem cells (ESCs) and has negative effects on ESC neural differentiation. However, it remains unclear when how BMP executes those different functions during commitment. Here, we show that BMP4-sensitive window exists Cells at this specific period correspond to egg cylinder stage epiblast can be maintained as ESC-derived (ESD-EpiSCs), which have same characteristics EpiSCs...
Knowledge of how Mediator and TFIID cross-talk contributes to promoter–enhancer (P-E) communication is important for elucidating the mechanism enhancer function. We conducted an shRNA knockdown screen in murine embryonic stem cells identify functional overlap between subunits on gene expression. Auxin-inducible degrons were constructed TAF12 MED4, eliciting greatest overlap. Degradation led a dramatic genome-wide decrease expression accompanied by destruction TFIID, loss Pol II preinitiation...
To study specific information on trends in incidence, mortality, disability-adjusted life years (DALY) and the corresponding among five sociodemographic index regions, 21 204 countries for decision-making, which would enable policymakers to distribute limited resources devise policies more rationally.Data uterine fibroids (UNs) from 1990 2019, including DALYs, were obtained 2019 Global Burden of Disease Study. An estimated annual percentage change (EAPC) was calculated assess morbidity, DALY...
Chromobox homolog 3 (Cbx3/heterochromatin protein 1γ [HP1γ]) stimulates cell differentiation, but its mechanism is unknown. We found that Cbx3 binds to gene promoters upon differentiation of murine embryonic stem cells (ESCs) neural progenitor (NPCs) and recruits the Mediator subunit Med26. RNAi knockdown either or Med26 inhibits while up-regulating genes involved in mesodermal lineage decisions. Thus, together ensure fidelity specification by enhancing expression down-regulating specific...
A key feature of RNA polymerase II (Pol II) preinitiation complexes (PICs) is their ability to coordinate transcription initiation with chromatin modification and remodeling. To understand how this coordination achieved, we employed extensive proteomic mechanistic analyses study the composition assembly PICs in HeLa cell mouse embryonic stem (ESC) nuclear extracts. Strikingly, most machinery that necessary for on part PIC. The PIC nearly identical between ESCs cells contains two major...
Abstract Background The incidence of ovarian cancer ranks third among gynecologic malignancies, but the mortality rate first. Methods expression GAS5 is low in and associated with survival patients according to public databases. overexpression inhibited malignancy by affecting proliferation migratory abilities OVCAR3 A2780 cells. increased cell apoptosis, cells were blocked G1 phase as assessed flow cytometry. Results We found that hnRNPK was a potential target gene, which regulated...
Abstract Neural induction is the initial event of nervous system development during which part ectoderm specified to become embryonic neural plate. The biological roles histone modification enzymes in early embryos remain unclear. Here, we show that an evolutionarily conserved dual demethylase KDM7A (KIAA1718) predominantly expressed epiblast cells primitive streak chick embryos. Overexpression leads expansion plate, whereas knockdown gene impairs formation We also regulates Fgf4 expression...
Cellular heterogeneity is a ubiquitous aspect of biology and major obstacle to successful cancer treatment. Several techniques have emerged quantify in live cells along axes including cellular migration, morphology, growth, signaling. Crucially, these studies reveal that not result randomness or failure control systems, but instead predictable multicellular systems. We hypothesize individual complex tissues can behave as reward-maximizing agents differences reward perception explain...
Abstract Acetyl‐CoAacyltransferase2 (ACAA2) is a key enzyme in the fatty acid oxidation pathway that catalyzes final step of mitochondrial β oxidation, which plays an important role metabolism. The expression ACAA2 closely related to occurrence and malignant progression tumors. However, function ovarian cancer unclear. level prognostic value were analyzed by databases. Gain loss carried out explore cancer. RNA‐seq bioinformatics methods applied illustrate regulatory mechanism ACAA2....
Although Lewis X (LeX) and Y (LeY) antigens were thought to play important roles in fertility, fucosyltransferase (Fut)-deficient (Fut1, Fut2 Fut4) mice which lack LeX or LeY antigen are still fertile. In the present study, Fut-deficient wild-type used measure expression of Fut mRNA along mouse male reproductive tract determine role each biosynthesis LeX/LeY antigens, conjugated glycoproteins system. LeX/LeY-containing detected epididymis, vas deferens, seminal vesicle coagulating gland, but...
Glycosyltransferases play a crucial role in various cancers. β1, 3-N-acetylglucosaminyltransferase 2, polylactosamine synthase, is an important member of the glycosyltransferase family. However, biological function and regulatory mechanism β3GNT2 esophageal carcinoma (ESCA) still poorly understood.The Cancer Genome Atlas Genotype-Tissue Expression databases were used for gene expression prognosis analysis. Quantitative real-time PCR, Western blot, immunohistochemistry performed to detect...
The microstructures and mechanical properties of the AZ31 Mg tubes fabricated by one-pass forward piercing tube extrusion are examined. grain size is refined from initial ∼75 μm down to 2—3 μm. room temperature uniaxial tensile elongations, measured along an axis that 0°, 45°, or 90° with respect direction, satisfactory, ranging 20 50%. However, hydroforming, under a more complicated stress state, results in poor formability as result strong basal plane texture. Rationalization terms Schmid...
1. Mechanical stimulation on dorsal surface of the spinal cord can evoke scratching movement in decerebrate cats.2. The area to scratch movements is located 2mm lateral central artery at level C1 and C2. lasted for 4-34 sec. latency ranged from less than 1 4 frequency was 1-4 per sec.3. In cats anesthetized with pentobarbital, could not be elicited.4. Pinna, galloping stepping reflex were also evoked by mechanical various levels cats.
Interest in the third-row transition metal osmium and its compounds as potential anticancer agents has grown recent years. Here, we synthesized osmium(VI) nitrido complex Na[OsVI(N)(tpm)2] (tpm = [5-(Thien-2-yl)-1H-pyrazol-3-yl]methanol), which exhibited a greater inhibitory effect on cell viabilities of cervical, ovarian, breast cancer lines compared with cisplatin. Proteomics analysis revealed that modulates expression protein-transportation-associated, DNA-metabolism-associated,...