A5057569930- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Laser Design and Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Spectroscopy and Laser Applications
- Plant-based Medicinal Research
- Occupational and environmental lung diseases
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Advanced Glycation End Products research
- Analytical Chemistry and Sensors
- Occupational exposure and asthma
- Lipoproteins and Cardiovascular Health
- Advanced Sensor Technologies Research
- Immune cells in cancer
- Amino Acid Enzymes and Metabolism
- Flavonoids in Medical Research
- Plasma Applications and Diagnostics
- Respiratory and Cough-Related Research
- Biomarkers in Disease Mechanisms
- Pulmonary Hypertension Research and Treatments
- IL-33, ST2, and ILC Pathways
- Plasma Diagnostics and Applications
- Gastric Cancer Management and Outcomes
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
Zhejiang University
2015-2025
Sir Run Run Shaw Hospital
2015-2025
Fudan University
2024
Zhejiang Provincial People's Hospital
2024
Hangzhou Medical College
2024
Dalian Institute of Chemical Physics
2006-2021
Chinese Academy of Sciences
2008-2021
Anhui Medical University
2014-2018
First Affiliated Hospital of Anhui Medical University
2014-2018
Anhui University of Traditional Chinese Medicine
2015
Abstract Epithelial mesenchymal transition (EMT) is a key progression that promotes pulmonary fibrosis (PF). Numb, phosphotyrosine-binding domain (PTB) protein, implicated with EMT. Nuclear factor erythroid 2-related factor2 (Nrf2) and its downstream proteins heme oxygenase-1 (HO-1) NAD(P)H: quinone oxidoreductase 1 (NQO1) constitute an important pathway of antioxidant defense signal for protecting against PF. It remains elusive whether Nrf2 Numb have potential relationship in EMT-mediated...
Abstract Epithelial-mesenchymal transition (EMT) is a phenotype conversion that plays critical role in the development of pulmonary fibrosis (PF). It known snail could regulate progression EMT. Nuclear factor erythroid 2 related (Nrf2), key regulator antioxidant defense system, protects cells against oxidative stress. However, it not whether Nrf2 regulates thereby modulating PF. Here, bleomycin (BLM) was intratracheally injected into both Nrf2-knockout (Nrf2 −/− ) and wild-type mice to...
Abstract Fibrosis in animal models and human diseases is associated with aberrant activation of the Wnt/β‐catenin pathway. Despite extensive research efforts, effective therapies are still not available. Myofibroblasts major effectors, responsible for extracellular matrix deposition. Inhibiting proliferation myofibroblast crucial treatment fibrosis. Proliferation myofibroblasts can have many triggering effects that result In recent years, Wnt pathway has been studied as an underlying factor...
Epithelial-to-mesenchymal transition (EMT) is a crucial event in the cellular origin of myofibroblasts that secrete extracellular matrix progression pulmonary fibrosis (PF). High-mobility group box 1 (HMGB1) novel mediator EMT. However, whether this process involves recognized transforming growth factor-<i>β</i>1 (TGF-<i>β</i>1)/Smad signaling also contributes to EMT PF has not yet been elucidated. Here, we developed model induced by bleomycin (BLM) rats and conducted several simulation...
Surveillance of drug safety is an important aspect in the routine medical care.Adverse events caused by real-world utilization has become one leading causes death and urgent issue field toxicology.Cardiovascular disease now cause fatal diseases most countries, especially elderly population who often suffer from multiple need long-term multidrug therapy.Among which, statins have been widely used to lower bad cholesterol regress coronary plaque mainly patients with hyperlipidemia...
Pulmonary fibrosis (PF) is a serious chronic lung disease with unknown pathogenesis. Researches have confirmed that oxidative stress which regulated by NADPH oxidase-4 (NOX4), main source of reactive oxygen species (ROS), an important molecular mechanism underlying PF. Previous studies showed total glucosides Danggui Buxue Tang (DBTG), extract from classical traditional Chinese herbal formula, (DBT), attenuated bleomycin-induced PF in rats. However, the mechanisms DBTG are still not clear....
Pulmonary fibrosis is a devastating lung disorder with mysterious pathogenesis and limited treatment options. It well-recognized that the uncontrolled proliferation of fibroblasts differentiation into myofibroblasts excessively produce extracellular matrix (ECM) proteins which contribute to change lungs. Thus, blocking ECM accumulation would delay progression. In this study, we observed effects astragaloside IV (ASV) (10 mg/kg/d) on in bleomycin (BLM, 5 mg/kg)-treated rats. Our results...
Qingre Sanjie Jiaonang (QRSJ) is a single herbal preparation from Senecio scandens Buch.-Ham.ex D. Don which has been proved to have anti-inflammatory and antioxidant effects. QRSJ used in treating upper respiratory tract inflammation acute bronchitis China for nearly twenty years. This study aims explore the potential effects of alleviating pulmonary fibrosis (PF) its mechanisms. A mouse model PF was induced by intratracheal injection Bleomycin (BLM, 5 mg/kg), followed different doses...
This study aimed to assess the national trends in osteoporosis prescriptions among Chinese adult outpatients aged less than 50 years with osteoporosis, from 2016 2019. Prescriptions for hospitals nine major areas were extracted database of Hospitals Prescription Analysis Cooperative Project. Trends annual and expenditure analyzed. The number hospital visits showed an increasing trend year by 18,412 23,447 2019 (P = 0.029), corresponding cost increased 2,083,872.94 yuan (CNY) 2,643,508.59 CNY...
Air pollution is a serious threat to human health. Inhaled fine particulate matter (PM2.5) can cause inflammation and oxidative stress in the airway; however, mechanisms responsible for this effect have yet be elucidated there are no specific drugs that prevent treat condition. In present study, we investigated effects underlying inhalation of salvianolic acid B (SalB) on PM2.5-induced airway stress. We used mouse model stress, along with epithelial cell model, study action SalB by...
Abstract Objective This study was to explore the antifibrotic effect and possible mechanism of total polysaccharides Yupingfeng (YPF-P) on bleomycin (BLM)-induced pulmonary fibrosis in rats. Methods Pulmonary induced Sprague-Dawley rats by BLM (5 mg/kg), killed 14 28 days after administration abdominal aorta exsanguination removed lungs. Lung coefficient counted at same time. Besides, H&E Masson's trichrome staining for histopathological changes lung tissues were observed. Additionally,...