A5103039961- Systemic Lupus Erythematosus Research
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Biochemical and Molecular Research
- Atherosclerosis and Cardiovascular Diseases
- Systemic Sclerosis and Related Diseases
- Erythrocyte Function and Pathophysiology
- Acute Myeloid Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Blood groups and transfusion
- Cervical Cancer and HPV Research
- Face Recognition and Perception
- Face recognition and analysis
- Acute Lymphoblastic Leukemia research
- Reproductive System and Pregnancy
- Peripheral Neuropathies and Disorders
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Platelet Disorders and Treatments
- Blood disorders and treatments
- Cell death mechanisms and regulation
- RNA modifications and cancer
- T-cell and B-cell Immunology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Visual Attention and Saliency Detection
Children's Hospital of Los Angeles
2025
University Health Network
2018-2024
University of Toronto
2011-2024
Baycrest Hospital
2022-2024
University of Pennsylvania
2017-2024
University of Mississippi Medical Center
2024
Cancer Research Institute
2017-2024
University of Alberta
2020-2024
Jackson Memorial Hospital
2024
Toronto Western Hospital
2016-2023
Oculodentodigital dysplasia (ODDD) is an autosomal dominant disorder characterized by pleiotropic developmental anomalies of the limbs, teeth, face and eyes that was shown recently to be caused mutations in gap junction protein alpha 1 gene (GJA1), encoding connexin 43 (Cx43). In course performing N-ethyl-N-nitrosourea mutagenesis screen, we identified a mouse mutation exhibits many classic symptoms ODDD, including syndactyly, enamel hypoplasia, craniofacial cardiac dysfunction. Positional...
Chlorinated hydrocarbons are lipophilic, toxic, and persistent in the environment animal tissues. They enter body food stored adipose tissue. Loss of fat through caloric restriction mobilizes lipophilic xenobiotics results distribution to other We have studied reversibility this process mice that followed a regimen weight cycling. Weight gain was by loss, second gain, loss ("yo-yo diet regimen"). measured orally gavaged [14C]hexachlorobenzene, which is sparingly metabolized. found cycling...
Disease activity in systemic lupus erythematosus follows three different courses: long quiescent, relapsing remitting and persistently active. However, the patterns of disease course since diagnosis are not known. This study aimed to assess prevalence characteristics such over 10 years.The inception cohort Toronto Lupus Clinic (≥10 year follow up, between visit interval ≤18 months) was investigated. Prolonged remission defined as a clinical Systemic Erythematosus Activity Index 2000 = 0...
To describe the frequency of myocardial infarction (MI) prior to diagnosis systemic lupus erythematosus (SLE) and within first 2 years follow-up.The international collaborating clinics (SLICC) atherosclerosis inception cohort enters patients 15 months SLE diagnosis. MIs were reported attributed on a specialised vascular event form. confirmed by one or more following: abnormal ECG, typical atypical symptoms with ECG abnormalities elevated enzymes (≥2 times upper limit normal), stress test,...
Abstract High-risk neuroblastoma remains therapeutically challenging to treat, and the mechanisms promoting disease aggression are poorly understood. Here, we show that elevated expression of dihydrolipoamide S-succinyltransferase (DLST) predicts poor treatment outcome aggressive in patients with neuroblastoma. DLST is an E2 component α-ketoglutarate (αKG) dehydrogenase complex, which governs entry glutamine into tricarboxylic acid cycle (TCA) for oxidative decarboxylation. During this...
Objectives This study aimed to evaluate the prevalence and incidence of herpes zoster (HZ) events describe its associated factors in a patients with SLE. Methods 491 consecutive SLE participants were screened for HZ using patient-reported questionnaire capture outcomes on pain other characteristics events. Sociodemographic, clinical laboratory measures also analysed, time-dependent Cox regression survival analyses performed investigate Results Prevalence was 30.5%, 14.3 cases per 1000...
Background SLE is an independent risk factor for cardiovascular disease (CVD). This study aimed to determine which among QRISK2, QRISK3, Framingham Risk Score (FRS), modified (mFRS) and Cardiovascular Equation (SLECRE) best predicts CVD. Methods a single-centre analysis on 1887 patients with followed prospectively according standard protocol. Tools’ scores were evaluated against CVD development at/within 10 years without For CVD, the index date score calculation was chosen as close prior...
Objective A recent study conducted by our clinical group demonstrated that low disease activity ( LDA ), defined as a Systemic Lupus Erythematosus Disease Activity Index 2000 SLEDAI ‐2K) score ≤2, maintained for 12 months, confers the same risk damage accrual complete remission after 2 years. The aim of present was to assess validity these findings in long term (10 years). Methods Patients inception cohort Toronto Clinic, who had minimum follow‐up 10 years and no interval >18 months...
To develop and validate a modification of SLEDAI-2K to accurately describe disease activity while accounting for glucocorticoid (GC) doses.The first two phases focused on the development index. Phase 1: identification scenarios real patients seen prospectively in longitudinal cohort. 2: derivation an equation that explains association between GC doses using physician global assessment as external construct. 3: comparison (SLEDAI-2KG), different cut-off points (4-7), identifying responders...
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive cancer of developing thymocytes, and remains fatal in 20% pediatric 50% adult patients.[1][1],[2][2] Frequent application multi-agent cytotoxic drugs leads to disease relapse high toxicities, underscoring the need for
To compare the performance of Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and SLEDAI-2K Glucocorticoids (SLEDAI-2KG) indices in identifying responders to standard care therapy.Data from adult patients seen between 1995 2018 at University Toronto Clinic were analyzed. Patients with active disease (SLEDAI-2K score ≥6) receiving prednisone ≥5 mg/day, a follow-up visit 9 months, studied. Response therapy first was assessed using SLEDAI-2KG. The performances SLEDAI-2KG...
Disease course in systemic lupus erythematosus (SLE) is primarily relapsing-remitting. Long quiescent and chronically active patterns are less frequent. We recently described an atypical "monophasic" a small number of patients. The aim the present study was to assess prevalence characteristics such patients defined SLE cohort.The inception University Toronto Lupus Clinic (enrolled within 18 mos diagnosis) were investigated. No time interval > months allowed between consecutive visits. A...
Objective To evaluate modified versions of the Belimumab International Study in Lupus Nephritis (BLISS-LN) belimumab study primary efficacy renal response (mPERR) and complete (mCRR) criteria (excluding mandatory corticosteroid tapering) as predictors real-world, long-term outcomes among patients with lupus nephritis (LN). Methods This retrospective, observational (GSK 212866) used deidentified data between 1970 2015 from University Toronto Cohort adults diagnosed systemic erythematosus...
Objective We previously demonstrated the utility of Automated Neuropsychological Assessment Metrics (ANAM) for screening cognitive impairment (CI) in patients with systemic lupus erythematosus (SLE) and developed composite indices interpreting ANAM results. Our objectives here were to provide further support ANAM’s concurrent criterion validity against American College Rheumatology neuropsychological battery (ACR-NB), identify most discriminatory subtests scores predicting CI, a new approach...