A5083595313- RNA regulation and disease
- Parkinson's Disease Mechanisms and Treatments
- RNA modifications and cancer
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Neurological diseases and metabolism
- Cancer Mechanisms and Therapy
- Neonatal Health and Biochemistry
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Nuclear Receptors and Signaling
- Cancer-related molecular mechanisms research
- Alzheimer's disease research and treatments
- Cannabis and Cannabinoid Research
- Cancer-related gene regulation
- Iron Metabolism and Disorders
Qingdao University
2022-2024
<p indent="0mm">Intrahepatic cholangiocarcinoma (ICC) accounts for approximately 15% of primary liver cancers, and the incidence rate has been increasing in recent years. Surgical resection is best treatment ICC, but 5-year survival less than 30%. ICC signature genes are crucial early diagnosis so it especially important to identify genes. The aim this study screen find potential target ICC. We that UBA3 highly expressed knockdown <italic>UBA3</italic> inhibits proliferation, invasion...
Alpha-synuclein (α-syn) is a major component of Lewy bodies, which biomarker Parkinson's disease (PD). It accumulates in substantia nigra pars compacta (SNpc) to form insoluble aggregates and cause neurotoxicity, often accompanied by iron deposition. We compared the reductase activity between monomeric α-syn (M-α-syn) oligomeric (O-α-syn) investigated effect on metabolism BV2 microglia cells as well. had ferric activity, O-α-syn stronger enzyme than M-α-syn. M-α-syn upregulated uptake...
Alpha-synuclein (α-syn) is a major component of lewy bodies, which biomarker Parkinson's disease (PD). It accumulates in substantia nigra pars compacts (SNpc) to form insoluble aggregates and cause neurotoxicity, often accompanied by iron deposition. In this study, we compared the reductase activity between monomeric α-syn (M-α-syn) oligomeric (O-α-syn), investigated effect on metabolism BV2 microglia cells as well. We found that had ferric activity, O-α-syn stronger enzyme than M-α-syn....
Abstract Background: Intrahepatic cholangiocarcinoma (ICC) accounts for about 15% of primary liver cancer, and the incidence rate has been rising in recent years. Surgical resection is best treatment ICC, but 5-year survival less than 30%. ICC signature genes are crucial early diagnosis so it especially important to find its genes. The aim this study investigate relationship between proliferation, invasion migration. Methods: We screened dataset from GEO analyzed differentially expressed...
Abstract Oligodendrocytes are the most iron-rich cells in brain. Studies have shown that oligodendrocytes very sensitive to oxidative stress, and iron overload is more likely cause damage oligodendrocytes. The purpose of this experiment was investigate damaging effect mechanism ferric ammonium citrate (FAC) on MO3.13 In FAC treatment group, intracellular concentration reactive oxygen species were increased. There no obvious changes nucleus chromatin, but increased mitochondrial membrane...