A5041459397- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver physiology and pathology
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Wnt/β-catenin signaling in development and cancer
- Microtubule and mitosis dynamics
- Cancer-related gene regulation
- Liver Disease Diagnosis and Treatment
- Abdominal Trauma and Injuries
- Hepatocellular Carcinoma Treatment and Prognosis
- Minimally Invasive Surgical Techniques
- Gallbladder and Bile Duct Disorders
- Cancer-related molecular mechanisms research
- Ovarian cancer diagnosis and treatment
- Circular RNAs in diseases
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- S100 Proteins and Annexins
- DNA Repair Mechanisms
- Viral-associated cancers and disorders
- Organ Transplantation Techniques and Outcomes
- Neuroendocrine Tumor Research Advances
Ministry of Agriculture and Rural Affairs
2025
Ningbo University
2025
Fuzhou University
2024-2025
Galapagos (Netherlands)
2024
Guizhou University
2024
Montgomery High School
2024
National Taiwan University Hospital
2012-2022
National Taiwan University
2004-2021
Sun Yat-sen University Cancer Center
2015
Sun Yat-sen University
2015
Mutations of the breast cancer susceptibility gene BRCA1 confer increased risk for breast, ovarian, and prostatic cancers, but it is not clear why mutations are associated with these particular tumor types. In transient transfection assays, was found to inhibit signaling by ligand-activated estrogen receptor (ER-α) through estrogen-responsive enhancer element block transcriptional activation function AF-2 ER-α. These results raise possibility that wild-type suppresses estrogen-dependent...
Hepatocellular carcinoma (HCC) is one of the most common fatal cancers worldwide. Other than sorafenib treatment, no effective systemic therapy has been available thus far. Most targets in molecularly targeted for cancer are receptor tyrosine kinases (RTKs). Therefore, identifying activated RTKs HCC critical developing new therapies. Using a phospho-RTK array, we found that Axl frequently liver cell lines. The knockdown by RNA interference significantly reduced migration and invasion lines...
Abstract Stathmin, a major microtubule‐depolymerizing protein, is involved in cell cycle progression and motility. This study aimed to elucidate its role the progression, early tumour recurrence (ETR), prognosis of hepatocellular carcinoma (HCC). Stathmin mRNA was overexpressed 88/156 (56%) resected, unifocal, primary HCCs, while p53 mutation present 72 (46%) osteopontin overexpression 79 (51%). expression exhibited high concordance (93%) with protein 107 cases examined by...
Collagen triple helix repeat containing-1 (CTHRC1) is a secreted glycoprotein that activates the planar cell polarity pathway of Wnt signaling. Using microarray analysis, we found CTHRC1 gene overexpressed in hepatocellular carcinoma (HCC). The level mRNA was measured 201 surgically resected HCCs using real time reverse transcription-polymerase chain reaction. Overexpression HCC associated with large tumor size and advanced stage. Furthermore, expression as identified an independent...
MicroRNAs (miRNAs) play critical roles in embryonic development and are frequently deregulated human cancers. The let-7 family members tumor-suppressing miRNAs downregulated cancer cells. Lin-28 Lin-28B RNA-binding proteins highly expressed tissues. block precursors from being processed to mature by inducing terminal uridylation degradation of precursors. Here, we report that Lin-28B, but not Lin-28, is hepatocellular carcinoma (HCC). expression was more noted high-grade HCCs with high...
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a 5-year survival rate of 9%. Major obstacles to successful treatment pancreatic cancer are the immunosuppressive tumor microenvironment (TME) and antigenic complexity or heterogeneity. Programmed death-ligand 1 (PD-L1) expressed on PDAC immunosuppressed cells within TME, providing suitable immunotherapy targets. We applied chimeric antigen receptor (CAR) strategy target immune checkpoint programmed death-1 (PD-1)/PD-L1...
Abstract Purpose: KIAA0101 is a proliferating cell nuclear antigen–associated factor and involved in proliferation. This study to elucidate its role the progression, early tumor recurrence (ETR), prognosis of hepatocellular carcinoma (HCC). Experimental Design: mRNA was measured by reverse transcription-PCR 216 resected, unifocal, primary HCCs protein 164 cases immunohistochemistry. Results: overexpressed 131 (61%) HCCs, detected 105 (64%). overexpression correlated with higher grade (P =...
Abstract Background and Objectives To investigate whether annexin A1 (ANXA1) expression is a marker in predicting the prognosis of oral cancer patients. Methods We immunohistochemically examined ANXA1 66 cases epithelial dysplasia (OED) 115 squamous cell carcinoma (OSCC). The results were correlated with clinicopathological parameters tumors overall patient survival. Results In normal mucosa, staining was predominantly located on membrane. OED OSCC specimens, membranous decreased, whereas...
Hepatocyte growth factor (HGF) is a secretory protein that plays important roles in cancer and metastasis. Lymphoid-enhancing 1 (LEF1) transcription mediating Wnt/β-catenin signaling. Using microarray analysis, we found HGF induced expression of LEF1 liver breast cell lines. through phosphatidylinositol 3-kinase/Akt nuclear factor-kappa B (NF-κB) Multiple NF-κB-binding sites were mapped within 3 kb upstream initiation site. NF-κB binding to site 2 was confirmed by chromatin...
Intraductal papillary neoplasms of the bile duct (IPN-Bs) share clinicopathologic features with intraductal mucinous (IPMNs) pancreas. Approximately two thirds IPMNs have activating point mutations GNAS at codon 201. The role mutation is unclear in IPN-B. In this study, we evaluated 41 patients diagnosed IPN-B for characteristics and follow-up information. Mutation analyses KRAS were performed. Twenty-three cases (56.1%) categorized as intestinal subtype, 18 (43.9%) considered...
The stinkbug Riptortus pedestris , notorious for inducing soybean staygreen-like syndrome, employs a range of salivary proteins to manipulate the host plant its benefit. Here, we show that RpSP1, protein specific Pentatomomorpha, triggers defense responses in multiple species. RpSP1 interacts with and stabilizes HSP40 family GmSPIP1 is dependent on induce cell death. We critical 22-amino acid peptide within acts as an intracellular insect-derived elicitor. Furthermore, enhances...
Laparoscopic cholecystectomy is the most common laparoscopic operation in world and accepted as standard procedure for cholecystectomy. Although use of miniendoscope diagnosis gynecological disease has been performed decades, using a 2-mm minilaparoscope new. From November 1996 to January 1997, 14 patients (6 men, 8 women; mean age 47 years) with gallbladder stone were treated by minilaparoscopic at National Taiwan University Hospital, Taipei, Taiwan. The entire was done through four ports...
G-protein-coupled receptor 30 (GPR30) has been reported to be a novel estrogen (ERa) in vitro. Therefore, the interactions among GPR30, ERa, progesterone (PR) and human epidermal growth factor receptor-2 (HER-2/neu), their prognostic utilities infiltrating ductal carcinoma (IDC) of breast were evaluated. Messenger RNA (mRNA) levels PR HER-2/neu tumor samples 118 Taiwanese IDC patients 27 non-tumor mammary tissues measured via quantitative polymerase chain reaction analyses. The correlations...