A5069755175- Photosynthetic Processes and Mechanisms
- Pluripotent Stem Cells Research
- Liver physiology and pathology
- Photoreceptor and optogenetics research
- Soil Carbon and Nitrogen Dynamics
- Plant Stress Responses and Tolerance
- Algal biology and biofuel production
- Plant nutrient uptake and metabolism
- Pancreatic function and diabetes
- Alzheimer's disease research and treatments
- Lipid metabolism and biosynthesis
- Liver Disease Diagnosis and Treatment
- Light effects on plants
- Ecology and Vegetation Dynamics Studies
- Bioenergy crop production and management
- Genetic Mapping and Diversity in Plants and Animals
- Forest Ecology and Biodiversity Studies
- Lipid Membrane Structure and Behavior
- CRISPR and Genetic Engineering
- ATP Synthase and ATPases Research
- Mycorrhizal Fungi and Plant Interactions
- Genetics, Aging, and Longevity in Model Organisms
- Nitric Oxide and Endothelin Effects
- Organ Transplantation Techniques and Outcomes
- Microbial Inactivation Methods
Zhengzhou Children's Hospital
2020-2023
Zhengzhou University
2020-2023
Nanjing Forestry University
2020-2023
Shandong Agricultural University
2016-2023
Zhejiang A & F University
2023
University of Chinese Academy of Sciences
2019-2020
Institute of Hydrobiology
2017-2020
Chinese Academy of Sciences
2017-2020
University of California Davis Medical Center
2005-2017
California Institute for Regenerative Medicine
2013
The Center for Biostabilization at UC Davis is attempting to stabilize mammalian cells in the dry state. We review here some of lessons from nature that we have been applying this enterprise, including use trehalose, a disaccharide found high concentrations many anhydrobiotic organisms, biological structures, both vitro and vivo. Trehalose has useful properties purpose least one case—human blood platelets—introducing sugar may be sufficient achieve stabilization. Nucleated cells, however,...
The NAC transcription factor family participates in responses to various kinds of environmental stimuli plants. Responses genes abiotic stresses have been widely studied, but their functions response biotic stress are little reported plants, especially crops. In the present study, we examined a novel tomato ( Solanum lycopersicum ) protein SlNAC35 and resistance by using transgenic tobacco. Expression analysis found that expression was induced drought stress, salt bacterial pathogen,...
Abstract Aim Arbuscular mycorrhizal fungi (AMF) are widely distributed soil organisms that play critical roles in ecosystem functions. However, little is known about their global distribution and the underlying mechanisms. Here, we aimed to explore pattern key predictors of AMF diversity abundance at scale. Location Global. Time Period 1987–2022. Major Taxa Studied fungi. Methods We investigated scale by compiling 654 field studies. Results found cold climate zones had relatively low...
Abstract Human induced pluripotent stem cells (hiPSCs) hold great potential for use in regenerative medicine, novel drug development, and disease progression/developmental studies. Here, we report highly efficient differentiation of hiPSCs toward a relatively homogeneous population functional hepatocytes. hiPSC-derived hepatocytes (hiHs) not only showed high expression hepatocyte-specific proteins liver-specific functions, but they also developed biotransformation system including phase I II...
The unicellular green alga, Chlamydomonas reinhardtii, is a classic model for studying flagella and biofuel. However, precise gene editing, such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) CRISPR-associated protein (Cas9) system, not widely used in this organism. Screening of random insertional mutant libraries by polymerase chain reaction provides an alternate strategy to obtain null mutants individual gene. But building, screening, maintaining library was...
Background Alcohol insult triggers complex events in the liver, promoting fibrogenic/inflammatory signals and more advanced cases, aberrant matrix deposition. It is well accepted that regenerative capacity of adult liver impaired during alcohol injury. The progenitor/stem cells have been shown to play an important role regeneration -in response various chronic injuries; however, effects on stem cell differentiation are not understood. Methods We employed hepatic progenitor derived from hESCs...
Abstract Background Grass carp ( Ctenopharyngodon idellus ) are important species in Asian aquaculture. A draft genome for grass has already been published 2015. However, there is still a requirement suitable genetic linkage map to arrange scaffolds on chromosomal frameworks. QTL analysis powerful tool detect key locations quantitative traits, especially There no growth related QTLs of have yet. Even the trait one focuses culture. Results In this study, pair distantly parent carps and their...
Aerobic photosynthetic organisms such as algae produce reactive oxygen species (ROS) by-products of metabolism. ROS damage biomolecules proteins and lipids in cells, but also act signaling molecules. The mechanisms that maintain the metabolic balance aerobic how cells specifically respond to different levels are unclear. Glutathione peroxidase (GPX) enzymes detoxify hydrogen peroxide or organic hydroperoxides, thus important components antioxidant system. In this study, we employed a...
Hepatocytes differentiated from human embryonic stem cells (ESCs) could provide a powerful tool for enabling cell-based therapies, studying the mechanisms underlying liver development and disease, testing efficacy safety of pharmaceuticals. However, currently most in vitro protocols yield hepatocytes with low levels function. In this study, we investigated potential Salvianolic acid B (Sal B), an active pharmaceutical compound present Salvia miltiorrhiza, which has been shown to have...
Abstract Chinese medicine, Fuzhenghuayu (FZHY), appears to prevent fibrosis progression and improve liver function in humans. Here we found that FZHY enhanced hepatocyte differentiation from human embryonic stem cells (hESC). After treatment with FZHY, albumin expression was consistently increased during maturation process of metabolizing enzymes transporter were also increased. Importantly, mesenchymal cell cholangiocyte marker significantly reduced by indicating one possible mechanism...
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic and often caused by obesity. Currently, moderate-intensity continuous training (MICT) high-intensity interval (HIIT) are two effective treatments for reducing fat mass in patients with obesity NAFLD. However, comparative fat-reducing effects underlying molecular mechanisms of MICT HIIT remain unclear. This comprehensive study was performed on male Wistar rats treated standard diet, high-fat MICT, to explore their...
Summary Heat stress causes dysfunction of the carbon‐assimilation metabolism. As a member Calvin–Benson–Bassham (CBB) cycle, chloroplast triose phosphate isomerases (TPI) catalyse interconversion glyceraldehyde 3‐phosphate (GAP) and dihydroxyacetone (DHAP). The tomato ( Solanum lycopersicum ) genome contains two individual SlTPI genes, Solyc10g054870 Solyc01g111120, which encode chloroplast‐located proteins SlTPI1 SlTPI2, respectively. tpi1 tpi2 single mutants had no visible phenotypes, but...
Embryonic stem cells (ESC) hold great potential for the treatment of liver diseases. Here, we report differentiation rhesus macaque ESC along a hepatocyte lineage. The undifferentiated monkey line, ORMES-6, was cultured in an optimal culture condition effort to differentiate them into hepatocyte-like vitro. functional efficacy differentiated hepatic evaluated using RT-PCR expression specific genes, and Western blot analysis immunocytochemistry proteins such as α-fetoprotein (AFP), albumin...