A5100655947- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Plant Diversity and Evolution
- Genomics and Chromatin Dynamics
- Plant and Fungal Species Descriptions
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Food Quality and Safety Studies
- Fungal Biology and Applications
- Hemoglobinopathies and Related Disorders
- Bacterial Genetics and Biotechnology
- Erythrocyte Function and Pathophysiology
- Cytokine Signaling Pathways and Interactions
- Microbial Metabolic Engineering and Bioproduction
- Immune cells in cancer
- Fern and Epiphyte Biology
- Mine drainage and remediation techniques
- Environmental DNA in Biodiversity Studies
- Synthesis of Organic Compounds
- Anaerobic Digestion and Biogas Production
- Building materials and conservation
- Curcumin's Biomedical Applications
- Microbial Metabolism and Applications
- Metabolism, Diabetes, and Cancer
First Affiliated Hospital of Sichuan Medical University
2024
Huazhong University of Science and Technology
2022-2024
Chongqing Medical University
2024
Children's Hospital of Philadelphia
2010-2019
Henan Normal University
2017-2019
China Rehabilitation Research Center
2017
Central Hospital of Zibo
2015
Chinese Academy of Medical Sciences & Peking Union Medical College
2007-2014
Jilin University
2009-2010
Shandong University
2006
The bicistronic microRNA (miRNA) locus miR-144/451 is highly expressed during erythrocyte development, although its physiological roles are poorly understood. We show that ablation in mice causes mild instability and increased susceptibility to damage after exposure oxidant drugs. This phenotype deeply conserved, as miR-451 depletion synergizes with stress cause profound anemia zebrafish embryos. At least some protective activities of stem from ability directly suppress production 14-3-3ζ, a...
Abstract MicroRNAs (miRNAs) are important posttranscriptional regulators in immune cells, but how viral infection regulates miRNA expression to shape dendritic cell (DC) responses has not been well characterized. We identified 20 miRNAs that were differentially expressed primary murine DCs response the dsRNA agonist polyinosinic-polycytidylic acid, a subset of which modestly regulated by influenza infection. miR-451 was unique because it induced more strongly splenic and lung live than...
The Yin Yang 1 (YY1) transcription factor has been identified to target a plethora of potential genes, which are important for cell proliferation and differentiation. Although the role that YY1 plays in different human types cancer reported, its biological mechanistic significance melanoma not well defined.Quantitative RT-PCR analysis was used determine whether aberrant miR-9 expression occurred melanoma, compared with benign nevi normal tissue controls. Furthermore, transcriptional...
Yarrowia lipolytica is progressively being employed as a workhouse for recombinant protein expression. Here, we expanded the molecular toolbox by engineering enolase promoter (pENO) and developed new self-excisable vector, based on this, combined strategy was to enhance expression of Thermomyces lanuginosus lipase (TLL) in Y. lipolytica. The strength 11 truncated promoters different length first identified using eGFP reporter. Seven were selected examine their ability driving TLL Then,...
Studies on the chaperone protein α-hemoglobin stabilizing (AHSP) reveal that abundant AHSP in erythroid cells enhance cells’ tolerance to oxidative stress imposed by excess pathological conditions. However, potential intracellular modulation of expression itself response is still unknown. The present study examined effect and molecular mechanism STAT3, an regulator, AHSP. increased K562 upon cytokine IL-6-induced STAT3 activation decreased knock-down cells. Regulation circumstance was then...
The promyelocytic leukemia (PML) can selectively and dynamically recruit a number of proteins including p53 to form sub-nuclear multiprotein chamber named PML-NBs. In DNA damage response, is recruited into PML-NBs modified by phosphorylations acetylations, which in turn potentiate its transcriptional pro-apoptotic activities. contrast, carcinoma cells, the role PML irradiation induced p53-mediated apoptosis not precisely understood. this study, we have used breast cell line, MCF-7, stably...
Copper is an essential element that maintains yeast physiological function at low concentrations, but toxic in excess. This study reported Cu(II) significantly promoted the yeast-to-hypha transition of Yarrowia lipolytica dose-dependent manner. Strikingly, intracellular accumulation was drastically reduced upon hyphae formation. Moreover, we investigated effect on Y. during dimorphic and found cellular viability thermomyces lanuginosus lipase (TLL) were both influenced by Cu(II)-induced...
The potential of fermentation broth Ganoderma lucidum (FBG) in improving the quality Chinese steamed bread (CSB) was firstly evaluated. sensory scores CSB treated by FBG are significantly higher than that control, and texture profile analysis also indicates increase hardness chewiness caused FBG. Observation on micro-structure shows formation larger pores expansion starch granules important reasons for improvement specific volume (volS), granule is due to gluten network distributed destroyed...
Objective For liquid biopsy of cancer, the extraction circulating cell-free DNA (cfDNA) from plasma is required. We evaluated efficacy use magnetic submicron particles coated with abundant small zwitterions (MSP-ZEWBs) for extracting short fragments cfDNA. Methods developed and optimized an MSP-ZEWB-based cfDNA method using ampholytic ion-exchange materials compared its results those a control kit. measured concentration by quantitative polymerase-chain-reaction Qubit analyzed fragmentation...
Objective: To estimate the bone protective effect of alpinumisoflavone, a natural prenylated isoflavonoid, against glucocorticoid-induced osteoporosis in rats. Methods: Male Wistar rats received intramuscular administration dexamethasone (4 mg/mL) at dose level 7 mg/kg for 5 weeks, and then alpinumisoflavone (5, 10, 15 mg/kg) alendronate (2 from 2 weeks. The body weight organ (femoral, vagina, uterus) were estimated. MicroCT analysis, turnover markers, parameters, oxidative stress...