A5101453138- Epigenetics and DNA Methylation
- Hematopoietic Stem Cell Transplantation
- Cancer-related gene regulation
- Genomics and Chromatin Dynamics
- Ferroptosis and cancer prognosis
- Mesenchymal stem cell research
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Ginseng Biological Effects and Applications
- Cancer, Hypoxia, and Metabolism
- Renal Diseases and Glomerulopathies
- MicroRNA in disease regulation
- Pharmacological Effects of Natural Compounds
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Liver physiology and pathology
- Traditional Chinese Medicine Studies
- Phagocytosis and Immune Regulation
- Autophagy in Disease and Therapy
- Mycobacterium research and diagnosis
- Galectins and Cancer Biology
- Natural product bioactivities and synthesis
- Monoclonal and Polyclonal Antibodies Research
Nanjing University of Chinese Medicine
2022-2025
BGI Genomics
2021-2024
Harvard University
2021-2024
BGI Group (China)
2021-2024
Zunyi Medical University
2023-2024
University of Copenhagen
2023
Harbin Medical University
2023
Third Affiliated Hospital of Harbin Medical University
2023
Minzu University of China
2022-2023
Massachusetts General Hospital
2019-2021
Ferroptosis is a recently discovered form of programmed cell death, but its regulatory mechanisms remain poorly understood. Here, we show that the RNA-binding protein ZFP36/TTP (ZFP36 ring finger protein) plays crucial role in regulating ferroptosis hepatic stellate cells (HSCs). Upon exposure to ferroptosis-inducing compounds, ubiquitin ligase FBXW7/CDC4 (F-box and WD repeat domain containing 7) decreased ZFP36 expression by recognizing SFSGLPS motif. FBXW7 plasmid contributed classical...
Ferroptosis is a recently discovered form of programmed cell death, but its regulatory mechanisms are not fully understood. In the current study, we reported that BRD7-P53-SLC25A28 axis played crucial role in regulating ferroptosis hepatic stellate cells (HSCs). Upon exposure to inducers, bromodomain-containing protein 7 (BRD7) expression was remarkably increased through inhibition ubiquitin-proteasome pathway. CRISPR/Cas9-mediated BRD7 knockout conferred resistance HSC ferroptosis, whereas...
Liver fibrosis is a key phase that will progress to further injuries such as liver cirrhosis or carcinoma. This study aimed investigate whether transplantation of bone marrow mesenchymal stromal cells (BM-MSCs) can attenuate in mice and the underlying mechanisms based on regulation macrophage subtypes.A model was induced by intraperitoneal (i.p.) injection CCl4 twice per week for 70 days, BM-MSCs were intravenously transplanted 60th 70th days. Immunohistology gene expression subtypes...
Background and AimsDevelopment of fibrosis in chronic liver disease requires activation hepatic stellate cells (HSCs) leads to a poor outcome. Artesunate (Art) is an ester derivative artemisinin that can induce ferroptosis HSCs, activated transcriptional factor 3 (ATF3) ATF/CREB transcription induced response stress. In this study, we examined the role Rho-associated protein kinase 1 (ROCK1)/ATF3 axis Art-induced HSCs.
WHSC1 is a histone methyltransferase that facilitates H3 lysine 36 dimethylation (H3K36me2), which permissive mark associated with active transcription. In this study, we revealed how regulates tumorigenesis and chemosensitivity of colorectal cancer (CRC). Our data showed as well H3K36me2 were highly expressed in clinical CRC samples, high expression poorer prognosis OS patients. reduction promoted colon cell apoptosis both vivo vitro. We found B lymphoma-2 (BCL2) expression, an...
Glucose metabolic disorders (GMD) can promote insulin resistance (IR) and diabetes, damage liver kidney.
We here explored whether perinatal nonylphenol (NP) exposure causes myocardial fibrosis (MF) during adulthood in offspring rats and determined the role of TGF-β1/LIMK1 signaling pathway NP-induced cardiac fibroblasts (CFs).
Background: Dachshund homolog 1 (DACH1) is widely acknowledged for its involvement in regulating diverse cell fates, but precise regulatory mechanism ferroptosis remains elusive. In this study, we investigated whether DACH1 modulates through affecting P53/solute carrier family 25 member 37 (SLC25A37) signaling hepatic fibrogenesis. Methods: CRISPR-Cas9 system was used to knockout HSC determine the effect of on ferroptosis. Immunoprecipitation, pulldown, and mouse model fibrogenesis were...
We discuss the article by Koizumi et al published in World Journal of Gastroenterology . Our focus is on therapeutic targets for fibrosis associated with alcohol-related liver disease (ALD) and mechanism action elafibranor (EFN), a dual agonist peroxisome proliferator-activated receptor α (PPARα) PPAR δ (PPARδ). EFN currently phase III clinical trials treatment metabolic dysfunction-associated fatty primary biliary cholangitis. ALD progresses from alcoholic to steatohepatitis (ASH), chronic...
Generation of proapoptotic sphingolipids by neutral sphingomyelinase activation is an early response to hypoxia/reoxygenation (HR) in cardiomyocytes. Factor associated with (FAN) mediates and subsequent apoptosis. However, the participation FAN HR-induced cardiomyocyte cell death has not been elucidated. We therefore investigated expression role rat A cDNA was isolated from heart encoding putative FAN. Reverse transcriptase-polymerase chain reaction, immunoelectron microscopy,...
Abstract Antibody–peptide epitope conjugates (APEC) are a new class of modified antibody–drug that redirect T-cell viral immunity against tumor cells. APECs contain tumor-specific protease cleavage site linked to patient-specific epitope, resulting in presentation epitopes on cancer cells and subsequent recruitment killing by CD8+ T Here we developed an experimental pipeline create identified preclinical therapies for ovarian carcinoma. Using functional assessment peptide antigen responses...
Diffuse large B cell lymphoma (DLBCL) is a highly heterogeneous type of non-Hodgkin with many molecular subtypes that can be distinguished by gene expression profiling (GEP). However, the pathogenesis DLBCL still unclear.The levels prolyl isomerase PIN-1 and other related proteins were determined in 73 primary patient samples lines Western blotting (WB) immunohistochemical (IHC) staining. Cell cycle apoptosis evaluated flow cytometry. Lymphoma viability was detected CCK-8 proliferation...
Abstract The epigenetic modifications of histones are essential markers related to the development and pathogenesis diseases, including human cancers. Mapping histone modification has emerged as widely used tool for studying regulation. However, existing approaches limited by fragmentation short-read sequencing represent average chromatin status in samples cannot provide information about long-range states. We leveraged advantage long read develop a method “BIND&MODIFY” profiling...