A5101490608- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Thermal Regulation in Medicine
- Nanoplatforms for cancer theranostics
- Helicobacter pylori-related gastroenterology studies
- Curcumin's Biomedical Applications
- Gut microbiota and health
- MXene and MAX Phase Materials
- Cancer Research and Treatments
- Tissue Engineering and Regenerative Medicine
- MicroRNA in disease regulation
- Immune cells in cancer
- Ultrasound and Hyperthermia Applications
- Mycobacterium research and diagnosis
- Histone Deacetylase Inhibitors Research
- Single-cell and spatial transcriptomics
- Virus-based gene therapy research
- Alcohol Consumption and Health Effects
- Renal and related cancers
- Heme Oxygenase-1 and Carbon Monoxide
- RNA modifications and cancer
- Protein Tyrosine Phosphatases
- Retinoids in leukemia and cellular processes
- Gastrointestinal motility and disorders
- Autophagy in Disease and Therapy
Shenyang Medical College
2025
First Affiliated Hospital of Zhengzhou University
2010-2025
BACKGROUND Hepatocellular carcinoma (HCC) is a malignant disease with high incidence and mortality worldwide. This study focuses on the TP53 target protein to investigate potential therapeutic effect of tetrahydrocurcumin (THC) HCC its mechanism action. The research hypothesis that THC can inhibit proliferation, migration, invasion cells, promote their apoptosis by regulating protein. AIM To explore which inhibits cell proliferation via signaling pathway. METHODS Potential targets were...
ABSTRACT Aims The objective of this study is to explore the regulatory role DNA methylation in delayed encephalopathy after carbon monoxide poisoning (DEACMP) and identify candidate epigenetic biomarkers. Methods In study, multi‐omics analyses such as methylomics, transcriptomics, pyrophosphate sequencing, qRT‐PCR, immunohistochemistry, western blotting were utilized investigate regulation altered gene expression pathogenesis DEACMP. Results Using integrated analysis, we identified 168...
We aimed to provide a new typing method for osteosarcoma (OS) based on single-cell RNA sequencing (scRNA-seq) and bulk RNA-seq data from the perspective of lipid metabolism examine its potential mechanisms in onset progression OS.Scores six metabolic pathways were calculated by single-sample gene set enrichment analysis (ssGSEA) scRNA-seq dataset three microarray expression profiles. Subsequently, cluster was conducted using unsupervised consistency clustering. Furthermore, clustering...
Cancer cells use glucose via glycolysis to maintain tumor cell proliferation. However, the effect of long non‑coding RNAs (lncRNAs) on in osteosarcoma (OS) remains unclear. The present study aimed investigate involvement lncRNA XLOC_005950/hsa‑microRNA (miR)‑542‑3p/phosphofructokinase, muscle (PFKM) axis regulation metabolism, proliferation and apoptosis progression OS. XLOC_005950, hsa‑miR‑542‑3p PFKM expression OS tissues was detected reverse transcription‑quantitative PCR analysis....
The aim of the present study was to investigate effects microRNA (miR)-183 on vitality, invasion, metastasis and apoptosis in osteosarcoma (OS) cells, mediated by its binding metastasis-associated protein 1 (MTA1). A dual luciferase reporter assay performed determine whether MTA1 a direct target miR-183. Cell Counting Kit-8, Transwell, scratch-wound healing, fluorescence-activated cell sorting andterminal deoxynucleotidyl transferase dUTP nick end labeling assays were also miR-183 expression...
Objective To investigate the degradation, osteoacusis, induction and biocompatibility of Hydroxyapatite ( HAP) coating magnesium alloy by implant them in rabbits' comdyles femur. Methods 33 rabbits were devided into 3 groups: they implanted material without with respectively, didin' t anything as control group. Observing variation serum through serology test to study side effect these materials. degradation newly formed bone radiology observation; time process surounding tissue skeletal...
Objective To study the killing effect of oncolytic adenovirus Ad11 combined with ifosfamide on human osteosarcoma cells and possible mechansim, provide cytological basis for Ad116 in treatment osteosarcoma. Methods The cell line MG63 was cultured vitro, 50% maximal concentration (EC50) 25% inhibitory (IC25) (IC50) adrephosphamide were detected by cytotoxicity assay (MTS method). The MTS method used to detect viability control group, group [multiplicity infection (MOI)=5], 1 (IC25=15...