A5101871168- Circular RNAs in diseases
- MicroRNA in disease regulation
- Marine Bivalve and Aquaculture Studies
- Cancer-related molecular mechanisms research
- Calcium Carbonate Crystallization and Inhibition
- RNA modifications and cancer
- Aldose Reductase and Taurine
- Physiological and biochemical adaptations
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Soil and Land Suitability Analysis
- Caveolin-1 and cellular processes
- Wheat and Barley Genetics and Pathology
- Silk-based biomaterials and applications
- Layered Double Hydroxides Synthesis and Applications
- Blood properties and coagulation
- Glutathione Transferases and Polymorphisms
- Ion channel regulation and function
- RNA Research and Splicing
- HER2/EGFR in Cancer Research
- Bioenergy crop production and management
- Natural Fiber Reinforced Composites
- Neurogenesis and neuroplasticity mechanisms
- Mycobacterium research and diagnosis
- Proteoglycans and glycosaminoglycans research
Beibu Gulf University
2018-2025
Tianjin Medical University General Hospital
2024
Zhengzhou University
2018-2022
Hunan Normal University
2022
Hunan Provincial People's Hospital
2022
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2022
Huazhong Agricultural University
2022
First Affiliated Hospital of Zhengzhou University
2022
Hainan Medical University
2020-2021
First Affiliated Hospital of GuangXi Medical University
2021
Abstract Background Human epidermal growth factor receptor 2 (HER2) is the most crucial ErbB tyrosine kinase (RTK) family member in HER2-positive (refered to HER2-overexpressing) breast cancer which are dependent on or "addictive" Phosphatidylinositol-3-kinase (PI3K) pathway. HER2-related target drugs trastuzumab and lapatinib have been foundation of treatment HER2--positive cancer. This study was designed explore relationship between PI3K pathway activation sensitivity metastatic patients...
Taurine and betaine are important nutrients in the Hong Kong oyster (Crassostrea hongkongensis) have many biological properties. To investigate characteristics of taurine identify single nucleotide polymorphisms (SNPs) associated with traits C. hongkongensis, we cloned full-length cDNA key genes involved metabolism (unpublished data), determined content gene expression different tissues months specimen collection, developed SNPs coding region. We that express cysteine dioxygenase sulfite...
Comparing the responses of closely related species to environmental changes is an efficient method explore adaptive divergence, for a better understanding evolution marine under rapidly changing climates. Oysters are keystone thrive in intertidal and estuarine areas where frequent disturbance occurs including fluctuant salinity. The evolutionary divergence two sister sympatric oysters,
The Pacific oyster Crassostrea gigas is an important cultivated shellfish. As a euryhaline species, it has evolved adaptive mechanisms responding to the complex and changeable intertidal environment that inhabits. To investigate genetic basis of this salinity adaptation mechanism, we conducted genome-wide association study using phenotypically differentiated populations (hyposalinity hypersalinity populations, control population), confirmed our results independent population, high-resolution...
Natural selection and genetic drift are both important for understanding the geographic distribution environmental responses of marine species. In this study, we revealed distinct variation in Crassostrea ariakensis by comparing COI gene segment sequence northern southern oysters separated Yangtze River estuary. Reciprocal hybridization intrapopulation crosses clarified their taxonomic status as same There was no heterosis survival growth hybrids, while maternal effect observed larvae from...
Abstract MicroRNA‐17‐5p (miR‐17‐5p) and epithelial‐mesenchymal transition (EMT) have been reported to participate in the development progression of multiple cancers. However, relationship between miR‐17‐5p EMT osteosarcoma (OS) is still poorly understood. This study was investigate effects its potential mechanism regulating proliferation, apoptosis, human OS. Quantitative real‐time PCR used detect SRC kinase signaling inhibitor 1 (SRCIN1) messenger RNA expression OS specimens cell lines....
Diabetes mellitus (DM) can be implicated in the perturbations of vascular integrity and dysfunction angiogenesis. Chitosan has advantage promoting endothelial cell proliferation. However, molecular mechanism action promotion wound healing by chitosan derivatives is still debated. In current study, DM with chronic (CW) model rats were prepared treated chitosan. Vascular cells isolated from granulation tissues conducted RNA sequencing. Two thousand three hundred sixteen genes up-regulated,...
The Hong Kong oyster (Crassostrea hongkongensis) lives in the brackish waters of estuaries intertidal zone and has a high resistance to low levels salinity, but higher levels. Juveniles are more sensitive salinity than adults. To better understand mechanisms underlying these differences, we performed high-salinity stress analysis juvenile adult oysters. Trait between groups showed that Na+-K+-ATPase activity, T-AOC, betaine, taurine glycogen content group were almost all control at 8 h under...
Osteoarthritis (OA) is a chronic degenerative joint disease and the most prevalent disabling form of arthritis worldwide. Autophagy plays vital role in OA. This study aimed to explore whether covalently closed circular RNA MSR (circRNA-MSR) could affect F-box Only Protein 21 (FBXO21) expression by targeting microRNA-761 (miR-761), thereby affecting autophagy OA chondrocytes. Clinical tissues were collected, circRNA-MSR, miR-761, FBXO21 expressions detected via quantitative real-time...
The present study aimed to identify a specific circular RNA (circRNA) for early diagnosis of gastric cancer (GC).Totally 82 patients with GC, 30 chronic nonatrophic gastritis and atrophic were included in this study. Four the GC selected screening. Total from malignant adjacent tissue samples was extracted, circRNAs four screened. According screening results, eight most upregulated downregulated statistically significant association identified by real-time fluorescent quantitative polymerase...
Cancer cells use glucose via glycolysis to maintain tumor cell proliferation. However, the effect of long non‑coding RNAs (lncRNAs) on in osteosarcoma (OS) remains unclear. The present study aimed investigate involvement lncRNA XLOC_005950/hsa‑microRNA (miR)‑542‑3p/phosphofructokinase, muscle (PFKM) axis regulation metabolism, proliferation and apoptosis progression OS. XLOC_005950, hsa‑miR‑542‑3p PFKM expression OS tissues was detected reverse transcription‑quantitative PCR analysis....
Osteoarthritis (OA) is a degenerative joint disease characterized by deterioration of articular cartilage functions. Previous studies have confirmed the role circular RNAs (circRNAs) in OA, but mechanical stress-related circRNA (circRNA-MSR) OA unknown.The human chondrocytes C28/I2 were cultured and treated with lipopolysaccharide (LPS) to establish model. The mRNA protein levels measured qRT-PCR or Western blot. Cell viability was analyzed MTT assay. Flow cytometry carried out detect cell...
A novel class of environmentally friendly protein-based bioplastics—cottonseed protein plastic sheets (CP-sheets)—were prepared by compression molding in the presence cottonseed flour as main raw material, aldehydes crosslink agent and glycerol plasticizer. FTIR, TGA, tensile tests water uptake measurements were applied to characterize structure, thermal stability, mechanical properties absorption CP-sheets. It was found that crosslinked CP-sheets (CP-FA, CP-GX CP-GA) showed higher stability...
(1) Background: At present, cancer cell metastasis is the main cause of death in patients with malignant tumors, and up to 23% osteosarcoma have died due lung lymph node metastasis. Therefore, finding new molecules involved tumor development can provide strategies for diagnosis treatment patients. Circular RNAs (circRNAs) are a type RNA molecule that connected head-to-tail form closed ring. There increasing evidence circRNAs many biological functions various diseases. However, role mechanism...
Abstract Production of viable progeny from interploid crosses requires precise regulation gene expression maternal and paternal chromosomes, yet the transcripts contributed to hybrid seeds polyploid parent species have rarely been explored. To investigate genome-wide contributions grain development, we analyzed transcriptomes developing embryos, zygote maturity, alongside endosperm in two stages using reciprocal between tetraploid hexaploid wheats. Reciprocal with varied levels ploidy...
Soil phosphorus is an important indicator to measure the soil fertility, because content of has effect on physical and chemical properties soil, plant growth, microbial activity in soil. In this study, samples collecting indoor analysis were conducted Zhoukou City located flooded area Yellow River. By using GIS combined with geo-statistics, we tried analyze spatial variability distribution total (TP) available (AP) study area. Results showed that TP AP both layers (0-20 cm 20-40 cm) rich,...
Detection of DNA methylome at single-base resolution is a significant challenge but promises to shed considerable light on human disease etiology. Current technologies could not detect methylation genome-wide with small amount sequencing data and avoid detecting the repetitive elements which are considered as "junk DNA". In this study, we have developed novel profiling technology named MB-seq its ability identify 5mC quantify levels by introduced an assistant adapter AluI-linker This linker...
To investigate the characteristics of taurine and betaine contents identify SNPs associated with traits in oyster Crassostrea hongkongensis, we cloned full-length cDNA key genes (unpublished data) metabolism, determined content gene expression different tissues months specimen collection, developed coding region. The involved metabolism were cysteine dioxygenase (ChCDO) sulfite decarboxylase (ChCSAD), and, choline dehydrogenase (ChCDH), aldehyde (ChBADH), homocysteine methyltransferase...
<title>Abstract</title> <bold>Background</bold> Taurine and betaine are important nutrients in <italic>Crassostrea hongkongensis</italic> have many biological properties. To investigate the characteristics of taurine contents identify SNPs associated with traits <italic>C.hongkongensis</italic>, we cloned full-length cDNA key genes (unpublished data) metabolism, determined content gene expression different tissues months specimen collection, developed coding region. <bold>Results</bold> We...