A5100606378- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Brain Metastases and Treatment
- Advanced Proteomics Techniques and Applications
- Food Quality and Safety Studies
- Seaweed-derived Bioactive Compounds
- Peptidase Inhibition and Analysis
- Trace Elements in Health
- Cancer, Lipids, and Metabolism
- Molecular Biology Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Gastric Cancer Management and Outcomes
- Medical Imaging and Pathology Studies
- RNA modifications and cancer
- Mass Spectrometry Techniques and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Phytochemical and Pharmacological Studies
- Protein Tyrosine Phosphatases
- Syphilis Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- Chronic Kidney Disease and Diabetes
- Bone Tumor Diagnosis and Treatments
- Wood and Agarwood Research
Shenyang Medical College
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Guangdong Pharmaceutical University
2024
Sun Yat-sen University
2013-2022
Sun Yat-sen University Cancer Center
2013-2022
Wuhan University
2021
Renmin Hospital of Wuhan University
2021
First Affiliated Hospital of Henan University of Traditional Chinese Medicine
2016
Huashan Hospital
2015
Fudan University
2015
Diabetic nephropathy (DN) has long been recognized as the leading cause of end-stage renal disease, but efficacy available strategies for prevention DN remains poor. The aim this study was to investigate possible beneficial effects fucoidan (FPS) in streptozotocin (STZ)-induced diabetes rats. Wistar rats were made diabetic by injection STZ after removal right kidney. FPS administered these 10 weeks. Body weight, physical activity, function, and morphometry measured weeks treatment. In...
Background The prognostic values of p reoperative n eutrophil/ l ymphocyte r atio ( NLR ), monocyte/lymphocyte ratio MLR and platelet/lymphocyte PLR ) in non‐small cell lung cancer NSCLC have been previously described. This study assessed the other pretreatment complete blood parameters C hinese patients with curatively resected . Methods A total 1466 consecutive who received curative surgery from J anuary 1, 2005 to D ecember 31, 2009 data tests were enrolled this retrospective study....
BACKGROUND Hepatocellular carcinoma (HCC) is a malignant disease with high incidence and mortality worldwide. This study focuses on the TP53 target protein to investigate potential therapeutic effect of tetrahydrocurcumin (THC) HCC its mechanism action. The research hypothesis that THC can inhibit proliferation, migration, invasion cells, promote their apoptosis by regulating protein. AIM To explore which inhibits cell proliferation via signaling pathway. METHODS Potential targets were...
Abstract Purpose: Effective biomarkers for the diagnosis of non–small cell lung cancer (NSCLC) are needed. We previously showed that isocitrate dehydrogenase 1 (IDH1) is significantly increased in NSCLC tumors. This study aimed to examine plasma levels IDH1 a large patient population evaluate its effectiveness diagnosis. Experimental Design: The IDH1, CA125, Cyfra21-1, and CEA were assayed by ELISA. Blood samples obtained from 1,422 participants (943 patients with 479 healthy controls)....
BACKGROUND The current study was undertaken to investigate the efficacy and safety of erlotinib versus pemetrexed as second‐line therapy for patients with advanced epidermal growth factor receptor (EGFR) wild‐type EGFR fluorescence in situ hybridization (FISH)‐positive lung adenocarcinoma. METHODS In this open‐label, randomized, phase 2 study, FISH‐positive adenocarcinoma who had developed disease progression after 1 prior platinum‐based chemotherapy were randomly assigned (1:1) receive or...
Reversed phase microcolumns have been widely used for peptide pretreatment to desalt and remove interferences before tandem LC-MS in proteomics studies. However, few studies characterized the effects of experimental parameters as well column characteristics on composition identified peptides. In this study, several including concentration ACN washing buffer, microcolumn's purification effect, recovery rate, dynamic-binding capacity were detail, based upon stable isotope labeling by amino...
ObjectivesTo investigate the prognostic capacity of baseline 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) metabolic parameters in extranodal natural killer/T-cell lymphoma (ENKTCL), and influence relative thresholds (RT) absolute (AT) selection on capacity.Materials methodsMetabolic tumor volume (MTV)-based were defined using RTs (41 % or 25 maximum standardized uptake value [SUVmax]), ATs (SUV 2.5, 3.0, 4.0, mean liver uptake) 133 patients....
Background Studies in EGFR + non‐small cell lung cancer (NSCLC) patients with leptomeningeal metastasis (LM) comparing survival rates and gene mutation detection matched cerebrospinal fluid (CSF) plasma are relatively scarce. We evaluated mutations, treatment strategies, clinical outcomes NSCLC LM. Methods retrospectively reviewed status the CSF of 32 LM for prognostic significance. Results The rate disease control was significantly higher that switched EGFR‐tyrosine kinase inhibitor (TKI)...
We aimed to verify the expression status and diagnostic significance of isocitrate dehydrogenase 1 (IDH1) in non-small-cell lung cancer (NSCLC), especially during early stages. Serum IDH1 levels were measured by ELISA. A total 1223 participants (660 patients with NSCLC, 276 healthy controls [HCs], 95 benign pulmonary conditions [BPCs], 135 other cancers [OCs], 57 samples interfering factors) divided into a training cohort validation according 3 testing centers. The concentrations NSCLC group...
Objective:The aim of this study was to use fractal dimension (FD) analysis on multidetector CT (MDCT) images for quantifying the morphological changes pulmonary artery tree in patients with hypertension (PH).Materials and Methods: Fourteen PH 17 without as controls were studied.All underwent contrast-enhanced helical transthoracic echocardiography.The trees generated using post-processing software, FD projected image area determined ImageJ software a personal computer.The FD, pressure (PAP)...
7519 Background: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) show great efficacy in patients with advanced non-small cell lung cancer (NSCLC) EGFR mutations. The BR.19 trial exploring the role of adjuvant gefitinib resected early stage NSCLC (stage IB 49%, II 38%, III 13%) did not significant progression-free survival (PFS) or overall (OS) improvement all patients. following chemotherapy mutation is unknown. Methods: In this open-label, phase study, IIIA-N2...
Abstract Background Diabetic kidney disease (DKD) is a microvascular complication of diabetes mellitus, contributing to end-stage renal with limited treatment options. The development DKD attributed podocyte injury resulting from abnormal autophagy. Consequently, the restoration autophagy deemed practicable approach in DKD. Methods mice were induced by streptozotocin and high-fat diet feeding. Following 8 weeks “QN” agarwood treatment, metrics such as albuminuria, serum creatinine (Scr),...
In stage III non-small cell lung cancer (NSCLC), prophylactic cranial irradiation (PCI) reduces the brain metastases incidence and prolongs progression-free survival without improving overall survival. PCI increases risk of toxicity is currently not adopted in routine care. Our objective was to assess cost-effectiveness compared with no NSCLC from a Dutch societal perspective.A cohort partitioned model developed based on individual patient data three randomized phase trials (N = 670)....
Lymph node metastasis is critical for the prognosis of non-small cell lung cancer (NSCLC) patients, and understanding pattern lymph key to treatment. We aim investigate N2 NSCLC patients without N1 involvement.From 1999 2005, a total 803 with pN2 were enrolled in this study. Among them, 137 no at hilar (N1) nodes [skip (+) group] compared other 666 (-) group].The percentage male, smoker squamous carcinoma significantly higher skip group, (83.21% vs. 64.11%, P<0.001; 76.64% 53.60%, 50.36%...
e20626 Background: Apatinib, a small-molecule inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2), has been proved to be effective and safe in treating patients with advanced gastric cancer who failed second-line chemotherapy. As the VEGFR-2 targeted therapy made encouraging progress treatment broad range malignancies, we aimed explore efficacy safety apatinib non-small cell lung after failure chemotherapy or other therapy. Methods: In this open-label single-arm, phase II...
Background: Few studies attempt to investigate the impact of histology on outcome nonsmall-cell lung cancer (NSCLC) patients. In this study, we aim determine whether type influenced stage IA NSCLC patients with tumor size (TS) ≤20 mm. Methods: The data population in our study was collected from Surveillance, Epidemiology, and End Results (SEER) program, which is supported by National Cancer Institute United States. primary overall survival (OS). Cox-regression proportional hazards models...