A5045053996- Immune cells in cancer
- Inflammasome and immune disorders
- Autophagy in Disease and Therapy
- interferon and immune responses
- COVID-19 Clinical Research Studies
- Ferroptosis and cancer prognosis
- Heme Oxygenase-1 and Carbon Monoxide
- COVID-19 diagnosis using AI
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- SARS-CoV-2 and COVID-19 Research
- Cancer Immunotherapy and Biomarkers
- Long-Term Effects of COVID-19
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Adipokines, Inflammation, and Metabolic Diseases
- Esophageal Cancer Research and Treatment
- IL-33, ST2, and ILC Pathways
- MicroRNA in disease regulation
- Mangiferin and Mango Extracts
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
Wuhan University
2020-2025
Renmin Hospital of Wuhan University
2020-2025
PurposeAimed to characterize the CT imaging and clinical course of asymptomatic cases with COVID-19 pneumonia.MethodsAsymptomatic pneumonia confirmed by SARS-COV-2 nucleic acid testing in Renmin Hospital Wuhan University were retrospectively enrolled. The characteristics feature collected analyzed.Results58 admitted our hospital between Jan 1, 2020 Feb 23, All patients had history exposure SARS-CoV-2. On admission, no symptoms laboratory findings normal. predominant this cohort was ground...
Itaconate, a metabolite produced during inflammatory macrophage activation, has been extensively described to be involved in immunoregulation, oxidative stress, and lipid peroxidation. As form of iron hydroperoxide-dependent regulated cell death, ferroptosis plays critical role sepsis-induced acute lung injury (ALI). However, the relationship between itaconate remains unclear. This study aims explore regulatory on ALI. In vivo experiments, mice were injected with LPS (10 mg/kg) for 12 h...
Abstract Background: NOD-like receptor family pyrin domain containing 3 (NLRP3)-mediated macrophage pyroptosis plays an important role in sepsis-induced acute lung injury (ALI). Inhibition of may be a way to alleviate inflammation as well tissue damage triggered after lipopolysaccharide (LPS) stimulation. The aim the present study was explore whether buformin (BF), hypoglycemic agent, could ALI by inhibiting pyroptosis. Methods: Wildtype C57BL/6 mice were randomly divided into control group,...
Fine particulate matter (PM2.5) is one of the most important components environmental pollutants and associated with lung injury. Pyroptosis, a form programmed cell death mainly mediated by NLRP3 inflammasome, has been reported to be involved in sepsis-induced or ischemia/reperfusion-induced However, specific mechanisms pyroptosis PM2.5-induced injury are not yet clear. We constructed macrophage-specific knockout mice explore mechanism terms inflammatory response, oxidative stress, apoptosis...
Esophageal microbiota plays important roles in esophageal cancer. Esophagectomy, as the most therapeutic way, contributes to changes of microbiome. However, there are few studies examining microbiome and metabolic before after esophagectomy. The present study characterized 17 patients with squamous cell carcinoma (ESCC), 11 esophagogastric junction (EGJ) cancer, 15 at 9–12 months radical esophagectomy 16 healthy controls (HC). 16S ribosomal RNA gene sequencing was used evaluate predict...
Activated inflammation and pyroptosis in macrophage are closely associated with acute lung injury (ALI). Histone deacetylase 3 (HDAC3) serves as an important enzyme that could repress gene expression by mediating chromatin remodeling. In this study, we found HDAC3 was highly expressed tissues of lipopolysaccharide (LPS)-treated mice. Lung from HDAC3-deficient mice stimulated LPS showed alleviative pathological inflammatory response. silencing significantly blocked the activation cyclic...
Background/Objectives: Glucocorticoid-induced osteonecrosis of the femoral head (GIOFH) is a debilitating condition resulting from impaired bone metabolism and vascular disruption due to prolonged glucocorticoid use. This study aimed explore therapeutic potential salvigenin, flavonoid with antioxidative estrogen-like properties, in alleviating GIOFH by modulating estrogen receptor alpha (ESR1) pathways. Methods: A network pharmacology approach was utilized identify salvigenin’s targets their...
Mangiferin (MF) is a natural phytopolyphenol, which displays potential pharmacological properties involving antibacterial, anti-inflammation, antioxidant and anti-tumor. However, little known about the roles of MF in lung injury. The aim this study to demonstrate modulatory effects molecular mechanisms by operates sepsis-induced injury.To examine protective MF, an vivo model lipopolysaccharide (LPS)-induced injury mice vitro LPS-treated J774A.1 cells were established, respectively. results...
Although breakthroughs have been made in the treatment of non-small cell lung cancer, there are only a few choices for advanced-stage or recurrent squamous carcinoma (LUSC) patients. In our study, we identified 7 major types thedepicted immunolandscape LUSC microenvironment using single-cell RNA sequencing. We found that an immunosuppressive receptor, T immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT), was highly expressed by regulatory cells (Tregs) exhausted...
Scope It is well‐established that dysregulated mitochondrial homeostasis in macrophages leads to inflammation, oxidative stress, and tissue damage, which are essential the pathogenesis of sepsis‐induced acute lung injury (ALI). Kahweol, a natural diterpene extracted from coffee beans, reportedly possesses anti‐inflammatory protective properties. Herein, study investigates whether Kahweol can alleviate ALI explore underlying mechanisms. Methods results C57BL/6J mice intraperitoneally injected...
Abstract Inflammation and immune processes underlie pulmonary hypertension progression. Two main different activated phenotypes of macrophages, classically M1 macrophages alternatively M2 are both involved in inflammatory related to hypertension. Recent advances suggest that coordinate interactions among proinflammatory anti-inflammatory mediators, other cellular components such as smooth muscle cells fibroblasts. In this review, we summarize the current literature on role pathogenesis...
Background: Tumor stroma is a crucial component of the tumor environment that interacted with cells and modulated cell proliferation, immune evasion, metastasis.Tumor-stromal ratio (TSR) has been confirmed as an influential independent prognostic factor for diverse types cancer, but it was seldom discussed in esophagus squamous carcinoma (ESCC).Methods: In present study, pathological sections from most invasive part ESCC 270 patients were analyzed their TSR by visual inspection software.The...
Acute pancreatitis (AP) is an acute inflammatory disorder characterized by acinar cell death and inflammation. Multiple factors cause hyperglycemia after AP. Macrophage polarization involved in tissue injury repair, regulated Notch signaling during certain diseases. The present study explores the relationship among hyperglycemia, macrophage polarization, AP related mechanisms. A cerulein-induced model was established FVB/N mice, with initiated injection of 50% concentration glucose. Tissue...
The engineered clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein (Cas) system is currently widely applied in genetic editing and transcriptional regulation. catalytically inactivated CasRx (dCasRx) has the ability to selectively focus on mRNA coding region without disrupting transcription translation, opening up new avenues for research RNA modification translation control. This utilized dCasRx create a translation-enhancement mammals called...