A5101540914- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- COVID-19 diagnosis using AI
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Tuberculosis Research and Epidemiology
- IL-33, ST2, and ILC Pathways
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Transplantation: Methods and Outcomes
- Sirtuins and Resveratrol in Medicine
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Parvovirus B19 Infection Studies
- Data-Driven Disease Surveillance
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Infectious Diseases and Tuberculosis
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Antibiotic Resistance in Bacteria
- Herpesvirus Infections and Treatments
Wuhan University
2020-2023
Renmin Hospital of Wuhan University
2020-2023
National Taiwan University
2021-2022
I-Shou University
2014
National Cheng Kung University
2014
Taiwan Nurses Association
2011
PurposeAimed to characterize the CT imaging and clinical course of asymptomatic cases with COVID-19 pneumonia.MethodsAsymptomatic pneumonia confirmed by SARS-COV-2 nucleic acid testing in Renmin Hospital Wuhan University were retrospectively enrolled. The characteristics feature collected analyzed.Results58 admitted our hospital between Jan 1, 2020 Feb 23, All patients had history exposure SARS-CoV-2. On admission, no symptoms laboratory findings normal. predominant this cohort was ground...
Itaconate, a metabolite produced during inflammatory macrophage activation, has been extensively described to be involved in immunoregulation, oxidative stress, and lipid peroxidation. As form of iron hydroperoxide-dependent regulated cell death, ferroptosis plays critical role sepsis-induced acute lung injury (ALI). However, the relationship between itaconate remains unclear. This study aims explore regulatory on ALI. In vivo experiments, mice were injected with LPS (10 mg/kg) for 12 h...
Background: Tumor stroma is a crucial component of the tumor environment that interacted with cells and modulated cell proliferation, immune evasion, metastasis.Tumor-stromal ratio (TSR) has been confirmed as an influential independent prognostic factor for diverse types cancer, but it was seldom discussed in esophagus squamous carcinoma (ESCC).Methods: In present study, pathological sections from most invasive part ESCC 270 patients were analyzed their TSR by visual inspection software.The...
Severe acute respiratory syndrome coronavirus (SARS-CoV-2) first emerged in December 2019 Wuhan, China, and has since spread rapidly worldwide. As researchers seek to learn more about COVID-19, the disease it causes, this novel virus continues infect kill. Despite socioeconomic impacts of SARS-CoV-2 infections likelihood future outbreaks other pathogenic coronaviruses, options prevent or treat remain limited. In current clinical trials, potential treatments focusing on killing preventing...
ABSTRACT Intragastric Klebsiella pneumoniae infections of mice can cause liver abscesses, necrosis tissues, and bacteremia. Lithium chloride, a widely prescribed drug for bipolar mood disorder, has been reported to possess anti-inflammatory properties. Using an intragastric infection model, the effects LiCl on K. were examined. Providing with drinking water containing immediately after protected them from -induced death injuries, such as well increasing blood levels aspartate...
In late December 2019, a pneumonia caused by SARS-CoV-2 was first reported in Wuhan and spread worldwide rapidly. Currently, no specific medicine is available to treat infection with COVID-19.The aims of this study were summarize the epidemiological clinical characteristics 175 patients who hospitalized Renmin Hospital University from January 1 31, 2020, establish tool identify potential critical COVID-19 help physicians prevent progression disease.In retrospective study, confirmed cases...
Herpes simplex virus (HSV) pneumonia is a rare disease and almost exclusively occurs in immunocompromised patients, such as those with malnutrition, malignancy, burns, severe pulmonary or human immunodeficiency infection.1 The pathological features of HSV include necrotizing tracheobronchitis, interstitial pneumonitis.2 diagnosis …
Abstract The purpose of this study was to compare the usefulness nucleic acid amplification (NAA) test against conventional tests under normal laboratory operational conditions. NAA performed on first sputum specimen all patients. Liquid media culture, solid and Ziehl–Neelsen stain for an acid‐fast bacilli (AFB) smear were three specimens. results calculated using gold standard either culture or clinical diagnosis. Of 593 patients tested, 151 (25.5%) diagnosed with pulmonary tuberculosis....
Background: An outbreak of the coronavirus disease 2019 (COVID-19) pneumonia caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) started in December 2019, Wuhan, China. Ground Glass Opacity (GGO) is most common image CT findings COVID-19 pneumonia. GGO also main imaging features early-stage lung cancer. We aimed to characterize and compare images featured with between patients cancer, facilitate early identification Methods: Patients (confirmed RT-PCR) GGO-manifested who...
Abstract Background: COVID-19 is spreading worldwide. No specific medicine has been used for the treatment of coronavirus infections. The aim this study to establish a new risk predictive model screen potential critical patients early intervention.Methods: In study, Clinical characteristics were collected and analyzed from 317 confirmed cases COVID-19. A total 175 with detailed examination results included models predicting disease progression. Major independent factors incorporated into...
Background: In late December 2019, a pneumonia caused by SARS-CoV-2 was first discovered in Wuhan, and it spread worldwide. Until now, no specific medicine has been used for the treatment of coronavirus infections. The aim this study is to establish new predictive model based on clinical characteristics COVID-19 predict independent risk factors that can be screen potential critical patients. Methods: First, 317 confirmed cases were retrospectively chosen study. Clinical collected analyzed. A...
<sec> <title>BACKGROUND</title> In late December 2019, a pneumonia caused by SARS-CoV-2 was first reported in Wuhan and spread worldwide rapidly. Currently, no specific medicine is available to treat infection with COVID-19. </sec> <title>OBJECTIVE</title> The aims of this study were summarize the epidemiological clinical characteristics 175 patients who hospitalized Renmin Hospital University from January 1 31, 2020, establish tool identify potential critical COVID-19 help physicians...
Abstract COPD is one of the high-risk factors for lung cancer, but underlying mechanism still unclear. Here, we performed single-cell RNA sequencing analysis on three tissues, and COPD-based cancer tissue (LCCOPD), enrolled scRNA-seq data normal LCCOPD tissues from public database. We found that most immune cell types were significantly enriched in groups, showed a differential enrichment T-regs macrophage subtypes comparison with COPD. FOXP3 mRNA expression was increased LCOPD-related...
Abstract COPD is one of the high-risk factors for lung cancer, but underlying mechanism still unclear. Here, we performed single-cell RNA sequencing analysis on three tissues, and COPD-based cancer tissue (LCCOPD), enrolled scRNA-seq data normal LCCOPD tissues from public database. We found that most immune cell types were significantly enriched in groups, showed a differential enrichment T-regs macrophage subtypes comparison with COPD. FOXP3 mRNA expression was increased LCOPD-related...
The carcinogenic mechanism of COPD is still unclear. We performed single-cell RNA sequencing on tissues, and COPD-overlapped lung cancer tissue (LCCOPD), enrolled the scRNA-seq data normal LCCOPD tissues from public. Most immune cell types were significantly enriched in groups. FOXP3 expression was increased LCCOPD-related T-regs positively associated with CTLA-4 PD-1 to form an immunosuppressive environment. Macrophages different pathological environments show significant differences...
Objective: To investigate the management strategies for lung transplant patients in Wuhan areas during COVID-19 epidemic period (from January 1, 2020 to April 8, 2020). Methods: During Renmin Hospital of University, three potential on waiting list were suspended operation, one who underwent transplantation was carefully quarantined and surrounding environment disinfected, nine after received prevention instructions followed up through phone call or online communication. The clinical...