A5101449590- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Gut microbiota and health
- Prostate Cancer Treatment and Research
- Congenital heart defects research
- Meat and Animal Product Quality
- Peptidase Inhibition and Analysis
- Cytokine Signaling Pathways and Interactions
- Sensory Analysis and Statistical Methods
- Chemokine receptors and signaling
- Amino Acid Enzymes and Metabolism
- Hedgehog Signaling Pathway Studies
- Genetics and Neurodevelopmental Disorders
- Inflammatory mediators and NSAID effects
- Protein Hydrolysis and Bioactive Peptides
- Polysaccharides and Plant Cell Walls
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Plant Stress Responses and Tolerance
- Gastrointestinal Tumor Research and Treatment
- Bladder and Urothelial Cancer Treatments
- Metastasis and carcinoma case studies
- Acne and Rosacea Treatments and Effects
National Taiwan University
1999-2024
Jiangsu Province Hospital
2023-2024
Anhui University
2023-2024
Nanjing University of Chinese Medicine
2023-2024
National Taipei University
2024
Nanjing Agricultural University
2020-2023
Hebei Medical University
2023
Fujian Chuanzheng Communications College
2023
Shantou Central Hospital
2022
University of Chicago
2018-2022
Abstract BACKGROUND Prostatic inflammation has been linked to a number of prostatic diseases such as benign hyperplasia (BPH), prostatitis syndromes, and prostate cancer. Major unanswered questions include what pathogenic mechanisms, bacterial infections, may drive the accumulation inflammatory infiltrates in human prostate, how might contribute disease. To study this potential link an vivo system, we developed mouse model long‐term bacteria‐induced chronic using prostatectomy‐derived strain...
Objective To compare the differences in gut microbiota and short-chain fatty acids (SCFAs; metabolites of microbiota) serum patients with first-episode depression healthy population to analyze relationship between metabolite SCFAs clinical symptoms major depressive disorder (MDD). Methods A total 45 22 volunteers were chosen complete relevant scale evaluations, feces samples venous blood collected. The 16S RNA method was used intestinal microflora characteristics detection by ELISA kit, as...
Abstract Calmodulin-like proteins (CMLs) are calcium (Ca2+) sensors involved in plant growth and development as well adaptation to environmental stresses; however, their roles responses cold not understood. To reveal the role of MsCML10 from alfalfa (Medicago sativa) regulating tolerance, we examined transgenic Medicago truncatula overexpressing MsCML10, MsCML10-RNAi alfalfa, a M. cml10-1 mutant identified MsCML10-interacting proteins. MtCML10 transcripts were induced by treatment....
Immune checkpoint inhibitors are groundbreaking resources for cancer therapy. However, only a few patients with hepatocellular carcinoma (HCC) have shown positive responses to anti-PD-1 Neoantigens sequence-altered proteins resulting from somatic mutations in cancer. This study identified the neoantigens of Hep-55.1C and Dt81 Hepa1-6 HCCs by comparing their whole exome sequences those normal C57BL/6 mouse liver. Immunogenic long peptides were pooled as peptide vaccines. The vaccination...
Idiopathic pulmonary fibrosis is incurable, and its progression difficult to control thus can lead deterioration. Pan-histone deacetylase inhibitors such as SAHA have shown potential for modulating yet with off-target effects. Therefore, selective HDAC would be beneficial reducing side Toward this goal, we designed synthesized 24 novel HDAC6, HDAC8, or dual HDAC6/8 established a two-stage screening platform rapidly screen that effectively mitigate TGF-β-induced fibrosis. The first stage...
Inflammation is commonly observed in radical prostatectomy specimens, and evidence suggests that inflammation may contribute to prostate carcinogenesis. Multiple microorganisms have been implicated serving as a stimulus for prostatic inflammation. The pro-inflammatory anaerobe, Propionibacterium acnes, ubiquitously found on human skin associated with the disease acne vulgaris. Recent studies shown P. acnes can be detected specimens by bacterial culture or culture-independent molecular...
This study was conducted to estimate prevalence rates and risk factors for late-life depression in a large nationwide representative sample from Taiwan.A total of 5,664, randomly sampled individuals aged ≥55 years were enrolled. Clinically, relevant depressive symptoms classified using the Center Epidemiological Studies Depression Scale (CES-D score ≥16), major confirmed Primary Care Evaluation Mental Disorders. Individuals with clinically symptoms, who did not meet strict diagnostic...
Calcium is an important second messenger in mediating adaptation responses of plants to abiotic and biotic stresses. Calmodulin-like (CML) protein calcium-signaling that can sense decode Ca2+ signal plants. Medicago truncatula a model legume plant; however, investigations MtCML proteins are limited. Using genome analysis BLAST database searches, fifty possess EF-hand motifs were identified. Phylogenetic showed CML homologs between M. truncatula, Arabidopsis thaliana Oryza sativa shared close...
In this study, different probiotics commonly used to produce fermented dairy products were inoculated independently for Chenopodium formosanum Koidz. fermentation. The strain with the highest level of antioxidant activity was selected and fermentation process further optimized via response surface methodology (RSM). Lactobacillus plantarum BCRC 11697 chosen because, compared other lactic acid bacteria, it exhibits increased free radical scavenging ability can more phenolic compounds, DPPH...
Short-chain dehydrogenase/reductase (SDR) belongs to the NAD(P)(H)-dependent oxidoreductase superfamily. Limited investigations reveal that SDRs participate in diverse metabolisms. A genome-wide identification of SDR gene family M. truncatula was conducted. total 213 MtSDR genes were identified, and they distributed on all chromosomes unevenly. proteins categorized into seven subgroups based phylogenetic analysis three types including ‘classic’, ‘extended’, ‘atypical’, depending...
Physical performance is a major determinant of health in older adults, and related to lifestyle factors. Dietary fiber has multiple benefits. It remains unclear whether intake independently linked superior physical performance. We aimed assess the association between dietary adults.This was cross-sectional study conducted with community-dwelling adults aged 55 years (n=2680) from ongoing Healthy Aging Longitudinal Study (HALST) Taiwan 2008-2010. Daily assessed using validated food frequency...
Scope Particulate matter (PM) contains toxic organic and heavy metals that enter the entire body through blood flow may cause mortality. Ganoderma formosanum mycelium, a valuable traditional Chinese medicine has been used since ancient times, various active ingredients can effectively impede inflammatory responses on murine alveolar macrophages induced by PM particles. Methods Results An experimental study assessing effect of G. mycelium extract's water fraction (WA) PM‐exposed using ROS...
Background Interleukin‐6 (IL‐6) is a mediator of inflammation that can facilitate prostate cancer progression. We previously demonstrated IL‐6 present in the tumor microenvironment and restricted almost exclusively to stromal compartment. The study examined influence paracrine signaling on growth using allograft models mouse (TRAMP‐C2), colon (MC38), melanoma (B16) cell lines wildtype (WT) knockout (IL‐6 −/− ) mice. Methods Cells were implanted into WT or mice sizes measured at 3 4 day...
Rhizopus oligosporus was utilized in the solid-state fermentation of Chenopodium formosanum sprouts (FCS) a bioreactor. Subsequently, antioxidant activity food proteins derived from FCS investigated. Results showed that glycine-rich peptide (GGGGGKP, G-rich peptide), identified < 2 kDa proteins, had values. According to SwissADME, AllerTOP, ToxinPred, and BIOPEP-UWM analyses, as safe, non-toxic, non-allergenic. Afterward, examined using silico vitro studies evaluate its potential alleviating...