Licochalcone A is a chalcone isolated from Glycyrrhiza uralensis. It showed anti-tumor and anti-inflammatory properties in mice with acute lung injuries regulated lipid metabolism through the activation of AMP-activated protein kinase (AMPK) hepatocytes. However, effects licochalcone on reducing weight gain improving nonalcoholic fatty liver disease (NAFLD) are unclear. Thus, present study investigated whether ameliorated loss high-fat diet (HFD)-induced obese mice. Male C57BL/6 were fed an...

Excess free fatty acid accumulation from abnormal lipid metabolism results in the insulin resistance peripheral cells, subsequently causing hyperinsulinemia, hyperglycemia and/or hyperlipidemia diabetes mellitus (DM) patients. Herein, we investigated effect of phenolic acids on glucose uptake an insulin-resistant cell-culture model and hepatic inflammation rats fed a high-fat diet (HFD). The show that vanillic (VA) demonstrated highest ability among all tested FL83B mouse hepatocytes....

This study investigated the effect of aqueous and ethanol soluble solid extracts guava (Psidium guajava Linn.) leaves on hypoglycemia glucose metabolism in type 2 diabetic rats. Low-dose streptozotocin (STZ) nicotinamide were injected into Sprague-Dawley (SD) rats to induce diabetes. Acute long-term feeding tests carried out, an oral tolerance test (OGTT) follow changes plasma insulin levels was performed evaluate antihyperglycemic leaf rats.The results acute showed a significant reduction...

Tumor necrosis factor-α was used to induce insulin resistance of mouse liver FL83B cells. Two phenolic acids, caffeic acid and cinnamic acid, were then added separately investigate their effects on glucose uptake the insulin-resistant The results suggest that these two acids may promote receptor tyrosyl phosphorylation, up-regulate expression signal associated proteins, including receptor, phosphatidylinositol-3 kinase, glycogen synthase, transporter-2, increase glucose, alleviate in cells...

This study investigated the alleviative effect of caffeic acid (CA) on Alzheimer's disease (AD) pathogenesis and associated mechanisms in high-fat (HF) diet-induced hyperinsulinemic rats. The results a Morris water maze indicated that, by administrating CA (30 mg/kg b.w./day) for 30 weeks, memory learning impairments HF-induced rats were significantly ameliorated. also enhanced superoxide dismutase glutathione free radical scavenger activity Western blot data further confirmed that protein...

Licochalcone A was isolated from Glycyrrhiza uralensis and previously reported to have antitumor anti-inflammatory effects. has also been found inhibit the levels of Th2-associated cytokines in bronchoalveolar lavage fluid (BALF) asthmatic mice. However, molecular mechanism underlying airway inflammation how licochalcone regulates oxidative stress mice are elusive. In this study, we investigated whether could attenuate inflammatory responses tracheal epithelial cells, it ameliorate...

Ginsenoside Rg3, isolated from Panax ginseng, has anti-inflammatory and anti-tumor activities. It is known to reduce inflammation in acute lung injury mice, the expression of inflammatory cytokines COX-2 human asthmatic airway epithelium. In this study, we attempted determine whether ginsenoside Rg3 inhibits inflammation, oxidative stress, hyperresponsiveness (AHR) lungs mice. We also investigated its effects on stress response tracheal epithelial cells.Asthma symptoms were induced female...

Punicalagin (PUN) was isolated from the peel of pomegranate (Punica granatum L.), is a polyphenol with anti-inflammatory, hepatoprotective, and antioxidant activities. However, it remains unclear whether PUN alleviates inflammation anti-inflammatory mechanisms in pro-inflammatory cytokines-induced human keratinocyte HaCaT cells. Here, we investigated that tumor necrosis factor-alpha (TNF-α) interferon-gamma (IFN-γ) mixture-stimulated cells were treated various concentrations PUN, followed by...

Tumour necrosis factor-α (TNF-α) plays a pivotal role in cellular insulin resistance and can induce mouse FL83B hepatocytes. Caffeic acid cinnamic were found to improve glucose uptake TNF-α-treated insulin-resistant The mechanism of metabolism by caffeic was further investigated. result from Western blot analysis revealed that increased expression glycogen synthase, whereas the synthase kinase phosphorylation at Ser641 hepatocytes decreased. suppressed hepatic nuclear factor-4 activity...

Phloretin is isolated from apple trees and could increase lipolysis in 3T3-L1 adipocytes. Previous studies have found that phloretin prevent obesity mice. In this study, we investigated whether ameliorates non-alcoholic fatty liver disease (NAFLD) high-fat diet (HFD)-induced obese mice, evaluated the regulation of lipid metabolism hepatocytes.HepG2 cells were treated with 0.5 mM oleic acid to induce accumulation, then evaluate molecular mechanism lipogenesis. another experiment, male C57BL/6...

Urolithin A is an active compound of gut-microbiota-derived metabolites polyphenol ellagic acid that has anti-aging, antioxidative, and anti-inflammatory effects. However, the effects urolithin on polyinosinic acid-polycytidylic (poly(I:C))-induced inflammation remain unclear. Poly(I:C) a double-stranded RNA (dsRNA) similar to virus recognized by Toll-like receptor-3 (TLR3), inducing inflammatory response in immune cells, such as macrophages. Inflammation natural defense process innate...

We previously demonstrated that acacetin reduces adipogenesis in adipocytes, and decreases lipid accumulation visceral adipocyte tissue. Here we investigated whether regulated the mechanisms of lipogenesis inflammation non-alcoholic fatty liver disease (NAFLD) obese mice. Male C57BL/6 mice were fed a high-fat diet (HFD), then administered by intraperitoneal injection. Acacetin reduced body weight Acacetin-treated exhibited decreased accumulation, increased glycogen improved hepatocyte...

People in oriental countries, including Japan and Taiwan, boil guava leaves (Psidium guajava L.) water drink the extract as a folk medicine for diabetes. The present study investigated enhancement of aqueous leaf on glucose uptake rat clone 9 hepatocytes searched active compound. was eluted with MeOH-H(2)O solutions through Diaion, Sephadex, MCI-gel columns to separate into fractions different polarities. test 2-[1-(14)C] deoxy-D-glucose performed evaluate hypoglycemic effect these...

This study investigated the ameliorative effect of gallic acid (GA) on hypertriglyceridemia and fat accumulation in perirenal adipose tissues high-fructose diet (HFD)-induced diabetic rats. The previous results showed that orally administered GA (30 mg/kg body weight) for four weeks significantly reduced levels plasma glucose triglyceride (TG) HFD also markedly decreased weight rats present (p < 0.05). Western blot assay indicated restored expression insulin signaling-related proteins, such...

Sesamol, isolated from sesame seeds (Sesamum indicum), was previously shown to have antioxidative, anti-inflammatory, and anti-tumor effects. Sesamol also inhibited lipopolysaccharide (LPS)-induced pulmonary inflammatory response in rats. However, it remains unclear how sesamol regulates airway inflammation oxidative stress asthmatic mice. This study aimed investigate the efficacy of on mice tracheal epithelial cells. BALB/c were sensitized with ovalbumin, received oral days 14 27....

Cytokine-induced endothelial dysfunction leads to inflammation and vascular adhesion molecule production in retinal pigment epithelium (RPE) cells. Inflammation is a critical mediator degeneration (RD) diseases, including age-related macular (AMD), RD progression may be prevented through anti-inflammatory activity RPE The flavonoid polyphenol luteolin (LU) has antidiabetes activities, but its effects regarding protection remain unknown. Here, we examined the ability of alleviate markers...

The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with type 2 diabetes mellitus (T2DM). activation nucleotide-binding domain and leucine-rich-containing family, pyrin domain-containing 3 (NLRP3) inflammasome in the may lead to hepatic fat accumulation. Alpha-lipoic acid (ALA) has been reported improve IR a T2DM rodent model. We investigated effects ALA on NLRP3 accumulation high-fat diet (HFD) plus streptozotocin (STZ)-induced rats. HFD/STZ-induced rats were orally...

Diabetes mellitus (DM) is often accompanied by clinical complications such as sarcopenia. Previous studies have indicated that oxidative stress and insulin resistance (IR) are highly associated with the pathogenesis of diabetic myopathy. α-lipoic acid (ALA), a potent biological antioxidant, exists abundantly in variety plants vegetables. This study aimed to investigate ameliorative effect ALA on muscle atrophy type 2 rats induced high-fat diet feeding (HFD) plus streptozotocin (STZ)...

: Maillard browning in ethanolic solutions of a 0.2 M glucose-0.2 glycine (G-G) system heat treatment becomes more pronounced with an increase ethanol concentration (0% to 50%, v/v). Extents browning, as measured by absorbance at 420 nm, fructose-glycine aqueous and 50% buffered pH 4.3 are very close after the treatment, whereas that G-G solution is much enhanced. A higher hydroxymethylfurfural (HMF) content present system, suggesting involvement reaction form HMF. Evidence also shows...